PDB entry 7f1s
View 7f1s on RCSB PDB site
Description: Cryo-EM structure of the apo chemokine receptor CCR5 in complex with Gi
Class: signaling protein
Keywords: G Protein-coupled receptor, Chemokine receptor CCR5, G protein, SIGNALING PROTEIN
Deposited on
2021-06-09, released
2021-07-14
The last revision prior to the SCOPe 2.08 freeze date was dated
2021-07-28, with a file datestamp of
2021-07-23.
Experiment type: EM
Resolution: 2.8 Å
R-factor: N/A
AEROSPACI score: 0.22
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: Guanine nucleotide-binding protein G(i) subunit alpha-1
Species: Homo sapiens [TaxId:9606]
Gene: GNAI1
Database cross-references and differences (RAF-indexed):
- Uniprot P63096 (0-353)
- engineered mutation (46)
- engineered mutation (201-202)
- engineered mutation (244)
- engineered mutation (325)
- Chain 'B':
Compound: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
Species: Homo sapiens [TaxId:9606]
Gene: GNB1
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.08: d7f1sb_ - Chain 'C':
Compound: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2
Species: Homo sapiens [TaxId:9606]
Gene: GNG2
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.08: d7f1sc_ - Chain 'R':
Compound: C-C chemokine receptor type 5
Species: Homo sapiens [TaxId:9606]
Gene: CCR5, CMKBR5
Database cross-references and differences (RAF-indexed):
- Uniprot P51681 (3-320)
- expression tag (0-2)
- engineered mutation (164)
- expression tag (321-366)
PDB Chain Sequences:
- Chain 'A':
No sequence available.
- Chain 'B':
Sequence, based on SEQRES records: (download)
>7f1sB (B:)
mseldqlrqeaeqlknqirdarkacadatlsqitnnidpvgriqmrtrrtlrghlakiya
mhwgtdsrllvsasqdgkliiwdsyttnkvhaiplrsswvmtcayapsgnyvacggldni
csiynlktregnvrvsrelaghtgylsccrflddnqivtssgdttcalwdietgqqtttf
tghtgdvmslslapdtrlfvsgacdasaklwdvregmcrqtftghesdinaicffpngna
fatgsddatcrlfdlradqelmtyshdniicgitsvsfsksgrlllagyddfncnvwdal
kadragvlaghdnrvsclgvtddgmavatgswdsflkiwn
Sequence, based on observed residues (ATOM records): (download)
>7f1sB (B:)
arkacadatlsqitnnidpvgriqmrtrrtlrghlakiyamhwgtdsrllvsasqdgkli
iwdsyttnkvhaiplrsswvmtcayapsgnyvacggldnicsiynlktregnvrvsrela
ghtgylsccrflddnqivtssgdttcalwdietgqqtttftghtgdvmslslapdtrlfv
sgacdasaklwdvregmcrqtftghesdinaicffpngnafatgsddatcrlfdlradqe
lmtyshdniicgitsvsfsksgrlllagyddfncnvwdalkadragvlaghdnrvsclgv
tddgmavatgswdsflkiwn
- Chain 'C':
Sequence, based on SEQRES records: (download)
>7f1sC (C:)
masnntasiaqarklveqlkmeanidrikvskaaadlmayceahakedplltpvpasenp
frekkffcail
Sequence, based on observed residues (ATOM records): (download)
>7f1sC (C:)
rikvskaaadlmayceahakedplltpvpasenpf
- Chain 'R':
No sequence available.