PDB entry 7f1q

View 7f1q on RCSB PDB site
Description: Cryo-EM structure of the chemokine receptor CCR5 in complex with MIP-1a and Gi
Class: signaling protein
Keywords: G Protein-coupled receptor, Chemokine Receptor CCR5, MIP-1a, SIGNALING PROTEIN
Deposited on 2021-06-09, released 2021-07-14
The last revision prior to the SCOPe 2.08 freeze date was dated 2021-07-28, with a file datestamp of 2021-07-23.
Experiment type: EM
Resolution: 2.9 Å
R-factor: N/A
AEROSPACI score: 0.21 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Guanine nucleotide-binding protein G(i) subunit alpha-1
    Species: Homo sapiens [TaxId:9606]
    Gene: GNAI1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P63096 (0-353)
      • engineered mutation (46)
      • engineered mutation (201-202)
      • engineered mutation (244)
      • engineered mutation (325)
  • Chain 'B':
    Compound: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
    Species: Homo sapiens [TaxId:9606]
    Gene: GNB1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d7f1qb_
  • Chain 'C':
    Compound: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2
    Species: Homo sapiens [TaxId:9606]
    Gene: GNG2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d7f1qc_
  • Chain 'R':
    Compound: C-C motif chemokine 3,C-C chemokine receptor type 5
    Species: Homo sapiens [TaxId:9606]
    Gene: CCR5, CMKBR5
    Database cross-references and differences (RAF-indexed):
    • Uniprot P10147 (0-68)
      • engineered mutation (14)
      • linker (69-92)
    • Uniprot P51681 (93-410)
      • engineered mutation (107)
      • engineered mutation (254)
      • expression tag (411-456)

PDB Chain Sequences:

  • Chain 'A':
    No sequence available.

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >7f1qB (B:)
mseldqlrqeaeqlknqirdarkacadatlsqitnnidpvgriqmrtrrtlrghlakiya
mhwgtdsrllvsasqdgkliiwdsyttnkvhaiplrsswvmtcayapsgnyvacggldni
csiynlktregnvrvsrelaghtgylsccrflddnqivtssgdttcalwdietgqqtttf
tghtgdvmslslapdtrlfvsgacdasaklwdvregmcrqtftghesdinaicffpngna
fatgsddatcrlfdlradqelmtyshdniicgitsvsfsksgrlllagyddfncnvwdal
kadragvlaghdnrvsclgvtddgmavatgswdsflkiwn

    Sequence, based on observed residues (ATOM records): (download) 
    >7f1qB (B:)
arkacadatlsqitnnidpvgriqmrtrrtlrghlakiyamhwgtdsrllvsasqdgkli
iwdsyttnkvhaiplrsswvmtcayapsgnyvacggldnicsiynlktregnvrvsrela
ghtgylsccrflddnqivtssgdttcalwdietgqqtttftghtgdvmslslapdtrlfv
sgacdasaklwdvregmcrqtftghesdinaicffpngnafatgsddatcrlfdlradqe
lmtyshdniicgitsvsfsksgrlllagyddfncnvwdalkadragvlaghdnrvsclgv
tddgmavatgswdsflkiwn

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >7f1qC (C:)
masnntasiaqarklveqlkmeanidrikvskaaadlmayceahakedplltpvpasenp
frekkffcail

    Sequence, based on observed residues (ATOM records): (download) 
    >7f1qC (C:)
rikvskaaadlmayceahakedplltpvpasenpf

  • Chain 'R':
    No sequence available.