PDB entry 7evz

View 7evz on RCSB PDB site
Description: Cryo-EM structure of cenerimod -bound Sphingosine-1-phosphate receptor 1 in complex with Gi protein
Class: membrane protein
Keywords: Homo sapiens, MEMBRANE PROTEIN
Deposited on 2021-05-24, released 2021-09-29
The last revision prior to the SCOPe 2.08 freeze date was dated 2021-09-29, with a file datestamp of 2021-09-24.
Experiment type: EM
Resolution: 3.07 Å
R-factor: N/A
AEROSPACI score: 0.19 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Guanine nucleotide-binding protein G(i) subunit alpha-1
    Species: Homo sapiens [TaxId:9606]
    Gene: GNAI1
    Database cross-references and differences (RAF-indexed):
  • Chain 'B':
    Compound: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
    Species: Homo sapiens [TaxId:9606]
    Gene: GNB1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P62873 (17-355)
      • initiating methionine (0)
      • expression tag (1-16)
    Domains in SCOPe 2.08: d7evzb1, d7evzb2
  • Chain 'C':
    Compound: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2
    Species: Homo sapiens [TaxId:9606]
    Gene: GNG2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d7evzc_
  • Chain 'D':
    Compound: Sphingosine 1-phosphate receptor 1
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 7EVZ (0-530)
  • Chain 'E':
    Compound: scFv16
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 7EVZ (0-265)
    Domains in SCOPe 2.08: d7evze_
  • Heterogens: JER, PLM

PDB Chain Sequences:

  • Chain 'A':
    No sequence available.

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >7evzB (B:)
mhhhhlevlfqgpgssgseldqlrqeaeqlknqirdarkacadatlsqitnnidpvgriq
mrtrrtlrghlakiyamhwgtdsrllvsasqdgkliiwdsyttnkvhaiplrsswvmtca
yapsgnyvacggldnicsiynlktregnvrvsrelaghtgylsccrflddnqivtssgdt
tcalwdietgqqtttftghtgdvmslslapdtrlfvsgacdasaklwdvregmcrqtftg
hesdinaicffpngnafatgsddatcrlfdlradqelmtyshdniicgitsvsfsksgrl
llagyddfncnvwdalkadragvlaghdnrvsclgvtddgmavatgswdsflkiwn

    Sequence, based on observed residues (ATOM records): (download) 
    >7evzB (B:)
gseldqlrqeaeqlknqirdarkacadatlsqitnnidpvgriqmrtrrtlrghlakiya
mhwgtdsrllvsasqdgkliiwdsyttnkvhaiplrsswvmtcayapsgnyvacggldni
csiynlktregnvrvsrelaghtgylsccrflddnqivtssgdttcalwdietgqqtttf
tghtgdvmslslapdtrlfvsgacdasaklwdvregmcrqtftghesdinaicffpngna
fatgsddatcrlfdlradqelmtyshdniicgitsvsfsksgrlllagyddfncnvwdal
kadragvlaghdnrvsclgvtddgmavatgswdsflkiwn

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >7evzC (C:)
masnntasiaqarklveqlkmeanidrikvskaaadlmayceahakedplltpvpasenp
frekkffcail

    Sequence, based on observed residues (ATOM records): (download) 
    >7evzC (C:)
tasiaqarklveqlkmeanidrikvskaaadlmayceahakedplltpvpasenpfre

  • Chain 'D':
    No sequence available.

  • Chain 'E':
    Sequence, based on SEQRES records: (download) 
    >7evzE (E:)
dvqlvesggglvqpggsrklscsasgfafssfgmhwvrqapekglewvayissgsgtiyy
adtvkgrftisrddpkntlflqmtslrsedtamyycvrsiyyygsspfdfwgqgttltvs
sggggsggggsggggsdivmtqatssvpvtpgesvsiscrssksllhsngntylywflqr
pgqspqlliyrmsnlasgvpdrfsgsgsgtaftltisrleaedvgvyycmqhleypltfg
agtklelkaaaenlyfqghhhhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >7evzE (E:)
vqlvesggglvqpggsrklscsasgfafssfgmhwvrqapekglewvayissgsgtiyya
dtvkgrftisrddpkntlflqmtslrsedtamyycvrsiyyygsspfdfwgqgttltvss
sdivmtqatssvpvtpgesvsiscrssksllhsngntylywflqrpgqspqlliyrmsnl
asgvpdrfsgsgsgtaftltisrleaedvgvyycmqhleypltfgagtklel