PDB entry 7epa

View 7epa on RCSB PDB site
Description: cryo-em structure of inactive mglu2 homodimer
Deposited on 2021-04-26, released 2021-06-23
The last revision was dated 2021-07-07, with a file datestamp of 2021-07-02.
Experiment type: EM
Resolution: 3.6 Å
R-factor: N/A
AEROSPACI score: 0.13 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Metabotropic glutamate receptor 2
    Species: Homo sapiens [TaxId:9606]
    Gene: GRM2, GPRC1B, MGLUR2
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q14416 (7-813)
      • expression tag (0-6)
      • engineered mutation (643)
      • engineered mutation (803)
      • expression tag (814-821)
  • Chain 'B':
    Compound: Metabotropic glutamate receptor 2
    Species: Homo sapiens [TaxId:9606]
    Gene: GRM2, GPRC1B, MGLUR2
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q14416 (7-813)
      • expression tag (0-6)
      • engineered mutation (643)
      • engineered mutation (803)
      • expression tag (814-821)

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >7epaA (A:)
dykddddegpakkvltlegdlvlgglfpvhqkggpaedcgpvnehrgiqrleamlfaldr
inrdphllpgvrlgahildscskdthaleqaldfvraslsrgadgsrhicpdgsyathgd
aptaitgviggsysdvsiqvanllrlfqipqisyastsaklsdksrydyfartvppdffq
akamaeilrffnwtyvstvasegdygetgieafeleararnicvatsekvgramsraafe
gvvrallqkpsarvavlftrsedarellaasqrlnasftwvasdgwgalesvvagsegaa
egaitielasypisdfasyfqsldpwnnsrnpwfrefweqrfrcsfrqrdcaahslravp
feqeskimfvvnavyamahalhnmhralcpnttrlcdamrpvngrrlykdfvlnvkfdap
frpadthnevrfdrfgdgigryniftylragsgryryqkvgywaegltldtslipwasps
agplpasrcsepclqnevksvqpgevccwlcipcqpyeyrldeftcadcglgywpnaslt
gcfelpqeyirwgdawavgpvtiaclgalatlfvlgvfvrhnatpvvkasgrelcyillg
gvflcycmtfifiakpstavctlrrlglgtafsvcysalltktyriarifggaregaqrp
rfispasqvaiclalisgqllivvawlvveapgtgketaperrevvtlrcnhrdasmlgs
laynvllialctlyafktrkcpenfneakfigftmyttciiwlaflpifyvtssdyrvqt
ttmcvsvslsgsvvlgclfapklyiilfqpqknveflevlfq

    Sequence, based on observed residues (ATOM records):
    >7epaA (A:)
kvltlegdlvlgglfpvhqkggpaedcgpvnehrgiqrleamlfaldrinrdphllpgvr
lgahildscskdthaleqaldfvraslsrgadgsrhicpdgsyathgdaptaitgviggs
ysdvsiqvanllrlfqipqisyastsaklsdksrydyfartvppdffqakamaeilrffn
wtyvstvasegdygetgieafeleararnicvatsekvgramsraafegvvrallqkpsa
rvavlftrsedarellaasqrlnasftwvasdgwgalesvvagsegaaegaitielasyp
isdfasyfqsldpwnnsrnpwfrefweqrfrcsfrqrdcaahslravpfeqeskimfvvn
avyamahalhnmhralcpnttrlcdamrpvngrrlykdfvlnvkfdapfrpadthnevrf
drfgdgigryniftylragsgryryqkvgywaegltldtslipwaspsagplpasrcsep
clqnevksvqpgevccwlcipcqpyeyrldeftcadcglgywpnasltgcfelpqeyirw
gdawavgpvtiaclgalatlfvlgvfvrhnatpvvkasgrelcyillggvflcycmtfif
iakpstavctlrrlglgtafsvcysalltktyriaispasqvaiclalisgqllivvawl
vveapgtgketaperrevvtlrcnhrdasmlgslaynvllialctlyafktrkcpenfne
akfigftmyttciiwlaflpifyvtssdyrvqtttmcvsvslsgsvvlgclfapklyiil
fq

  • Chain 'B':
    Sequence, based on SEQRES records:
    >7epaB (B:)
dykddddegpakkvltlegdlvlgglfpvhqkggpaedcgpvnehrgiqrleamlfaldr
inrdphllpgvrlgahildscskdthaleqaldfvraslsrgadgsrhicpdgsyathgd
aptaitgviggsysdvsiqvanllrlfqipqisyastsaklsdksrydyfartvppdffq
akamaeilrffnwtyvstvasegdygetgieafeleararnicvatsekvgramsraafe
gvvrallqkpsarvavlftrsedarellaasqrlnasftwvasdgwgalesvvagsegaa
egaitielasypisdfasyfqsldpwnnsrnpwfrefweqrfrcsfrqrdcaahslravp
feqeskimfvvnavyamahalhnmhralcpnttrlcdamrpvngrrlykdfvlnvkfdap
frpadthnevrfdrfgdgigryniftylragsgryryqkvgywaegltldtslipwasps
agplpasrcsepclqnevksvqpgevccwlcipcqpyeyrldeftcadcglgywpnaslt
gcfelpqeyirwgdawavgpvtiaclgalatlfvlgvfvrhnatpvvkasgrelcyillg
gvflcycmtfifiakpstavctlrrlglgtafsvcysalltktyriarifggaregaqrp
rfispasqvaiclalisgqllivvawlvveapgtgketaperrevvtlrcnhrdasmlgs
laynvllialctlyafktrkcpenfneakfigftmyttciiwlaflpifyvtssdyrvqt
ttmcvsvslsgsvvlgclfapklyiilfqpqknveflevlfq

    Sequence, based on observed residues (ATOM records):
    >7epaB (B:)
kvltlegdlvlgglfpvhqkggpaedcgpvnehrgiqrleamlfaldrinrdphllpgvr
lgahildscskdthaleqaldfvraslsrgadgsrhicpdgsyathgdaptaitgviggs
ysdvsiqvanllrlfqipqisyastsaklsdksrydyfartvppdffqakamaeilrffn
wtyvstvasegdygetgieafeleararnicvatsekvgramsraafegvvrallqkpsa
rvavlftrsedarellaasqrlnasftwvasdgwgalesvvagsegaaegaitielasyp
isdfasyfqsldpwnnsrnpwfrefweqrfrcsfrqrdcaahslravpfeqeskimfvvn
avyamahalhnmhralcpnttrlcdamrpvngrrlykdfvlnvkfdapfrpadthnevrf
drfgdgigryniftylragsgryryqkvgywaegltldtslipwaspsagplpasrcsep
clqnevksvqpgevccwlcipcqpyeyrldeftcadcglgywpnasltgcfelpqeyirw
gdawavgpvtiaclgalatlfvlgvfvrhnatpvvkasgrelcyillggvflcycmtfif
iakpstavctlrrlglgtafsvcysalltktyriaispasqvaiclalisgqllivvawl
vveapgtgketaperrevvtlrcnhrdasmlgslaynvllialctlyafktrkcpenfne
akfigftmyttciiwlaflpifyvtssdyrvqtttmcvsvslsgsvvlgclfapklyiil
fq