PDB entry 7eos

View 7eos on RCSB PDB site
Description: structure of the human glun1/glun2a nmda receptor in the glycine/glutamate bound state
Deposited on 2021-04-22, released 2021-06-30
The last revision was dated 2021-08-18, with a file datestamp of 2021-08-13.
Experiment type: EM
Resolution: 3.9 Å
R-factor: N/A
AEROSPACI score: 0.14 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Glutamate receptor ionotropic, NMDA 2A
    Species: Homo sapiens [TaxId:9606]
    Gene: GRIN2A, NMDAR2A
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q12879 (0-841)
      • engineered mutation (793)
      • expression tag (842-852)
  • Chain 'B':
    Compound: Glutamate receptor ionotropic, NMDA 1
    Species: Homo sapiens [TaxId:9606]
    Gene: Grin1, Nmdar1
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q05586 (0-846)
      • engineered mutation (697)
  • Chain 'C':
    Compound: Glutamate receptor ionotropic, NMDA 2A
    Species: Homo sapiens [TaxId:9606]
    Gene: GRIN2A, NMDAR2A
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q12879 (0-841)
      • engineered mutation (793)
      • expression tag (842-852)
  • Chain 'D':
    Compound: Glutamate receptor ionotropic, NMDA 1
    Species: Homo sapiens [TaxId:9606]
    Gene: Grin1, Nmdar1
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q05586 (0-846)
      • engineered mutation (697)
  • Heterogens: NAG

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >7eosA (A:)
mgrvgywtllvlpallvwrgpapsaaaekgppalniavmlghshdvterelrtlwgpeqa
aglpldvnvvallmnrtdpkslithvcdlmsgarihglvfgddtdqeavaqmldfissht
fvpilgihggasmimadkdptstffqfgasiqqqatvmlkimqdydwhvfslvttifpgy
refisfvkttvdnsfvgwdmqnvitldtsfedaktqvqlkkihssvillycskdeavlil
searslgltgydffwivpslvsgntelipkefpsglisvsyddwdyslearvrdgigilt
taassmlekfsyipeakascygqmerpevpmhtlhpfmvnvtwdgkdlsfteegyqvhpr
lvvivlnkdrewekvgkwenhtlslrhavwpryksfsdcepddnhlsivtleeapfvive
didpltetcvrntvpcrkfvkinnstnegmnvkkcckgfcidilkklsrtvkftydlylv
tngkhgkkvnnvwngmigevvyqravmavgsltineersevvdfsvpfvetgisvmvsrs
ngtvspsaflepfsasvwvmmfvmllivsaiavfvfeyfspvgynrnlakgkaphgpsft
igkaiwllwglvfnnsvpvqnpkgttskimvsvwaffaviflasytanlaafmiqeefvd
qvtglsdkkfqrphdysppfrfgtvpngsternirnnypymhqymtkfnqkgvedalvsl
ktgkldafiydaavlnykagrdegcklvtigsgyifattgygialqkgspwkrqidlall
qfvgdgemeeletcwltgichneknevmssqldidnmagvfymlaaamalslitfiwehl
fyksraeakrmkg

    Sequence, based on observed residues (ATOM records):
    >7eosA (A:)
lniavmlghshdvterelrtlwgpeqaaglpldvnvvallmnrtdpkslithvcdlmsga
rihglvfgddtdqeavaqmldfisshtfvpilgihggasmimadkdptstffqfgasiqq
qatvmlkimqdydwhvfslvttifpgyrefisfvkttvdnsfvgwdmqnvitldtsfeda
ktqvqlkkihssvillycskdeavlilsearslgltgydffwivpslvsgntelipkefp
sglisvsyddwdyslearvrdgigilttaassmlekfsyipeakascygqmerpevpmht
lhpfmvnvtwdgkdlsfteegyqvhprlvvivlnkdrewekvgkwenhtlslrhavwpry
ksfsdcepddnhlsivtleeapfvivedidpltetcvrntvpcrkfvkinnstnegmnvk
kcckgfcidilkklsrtvkftydlylvtngkhgkkvnnvwngmigevvyqravmavgslt
ineersevvdfsvpfvetgisvmvsrsngflepfsasvwvmmfvmllivsaiavfvfeyf
spsftigkaiwllwglvfnnsvpvqnttskimvsvwaffaviflasytanlaafmiqdqv
tglsdkkfqrphdysppfrfgtvpngsternirnnypymhqymtkfnqkgvedalvslkt
gkldafiydaavlnykagrdegcklvtigsgyifattgygialqkgspwkrqidlallqf
vgdgemeeletcwltgichdidnmagvfymlaaamalslitfiw

  • Chain 'B':
    Sequence, based on SEQRES records:
    >7eosB (B:)
mstmrlltlallfscsvaraacdpkivnigavlstrkheqmfreavnqankrhgswkiql
natsvthkpnaiqmalsvcedlissqvyailvshpptpndhftptpvsytagfyripvlg
lttrmsiysdksihlsflrtvppyshqssvwfemmrvyswnhiillvsddhegraaqkrl
etlleereskaekvlqfdpgtknvtallmeakelearviilsaseddaatvyraaamlnm
tgsgyvwlvgereisgnalryapdgilglqlingknesahisdavgvvaqavhelleken
itdpprgcvgntniwktgplfkrvlmsskyadgvtgrvefnedgdrkfanysimnlqnrk
lvqvgiyngthvipndrkiiwpggetekprgyqmstrlkivtihqepfvyvkptlsdgtc
keeftvngdpvkkvictgpndtspgsprhtvpqccygfcidlliklartmnftyevhlva
dgkfgtqervnnsnkkewngmmgellsgqadmivapltinneraqyiefskpfkyqglti
lvkkeiprstldsfmqpfqstlwllvglsvhvvavmlylldrfspfgrfkvnseeeeeda
ltlssamwfswgvllnsgigegaprsfsarilgmvwagfamiivasytanlaaflvldrp
eeritgindprlrnpsdkfiyatvkqssvdiyfrrqvclstmyrhmekhnyesaaeaiqa
vrdnklhafiwdsavlefeasqkcdlvttgelffrsgfgigmrkdspwkqnvslsilksh
engfmedldktwvryqecdsrsnapatltfenmagvfmlvaggivagiflifieiaykrh
kdarrkq

    Sequence, based on observed residues (ATOM records):
    >7eosB (B:)
kivnigavlstrkheqmfreavnqankrhgswkiqlnatsvthkpnaiqmalsvcedlis
sqvyailvshpptpndhftptpvsytagfyripvlglttrmsiysdksihlsflrtvppy
shqssvwfemmrvyswnhiillvsddhegraaqkrletlleereskaekvlqfdpgtknv
tallmeakelearviilsaseddaatvyraaamlnmtgsgyvwlvgereisgnalryapd
gilglqlingknesahisdavgvvaqavhellekenitdpprgcvgntniwktgplfkrv
lmsskyadgvtgrvefnedgdrkfanysimnlqnrklvqvgiyngthvipndrkiiwpgg
etekprgyqmstrlkivtihqepfvyvkptlsdgtckeeftvngdpvkkvictgpndtsp
gsprhtvpqccygfcidlliklartmnftyevhlvadgkfgtqervnnsnkkewngmmge
llsgqadmivapltinneraqyiefskpfkyqgltilvkkeiprstldsfmqpfqstlwl
lvglsvhvvavmlylldrfsltlssamwfswgvllnsgigsfsarilgmvwagfamiiva
sytanlaaflvldrpeeritgindprlrnpsdkfiyatvkqssvdiyfrrqvclstmyrh
mekhnyesaaeaiqavrdnklhafiwdsavlefeasqkcdlvttgelffrsgfgigmrkd
spwkqnvslsilkshengfmedldktwvryqectfenmagvfmlvaggivagiflifiei
aykrhkdar

  • Chain 'C':
    Sequence, based on SEQRES records:
    >7eosC (C:)
mgrvgywtllvlpallvwrgpapsaaaekgppalniavmlghshdvterelrtlwgpeqa
aglpldvnvvallmnrtdpkslithvcdlmsgarihglvfgddtdqeavaqmldfissht
fvpilgihggasmimadkdptstffqfgasiqqqatvmlkimqdydwhvfslvttifpgy
refisfvkttvdnsfvgwdmqnvitldtsfedaktqvqlkkihssvillycskdeavlil
searslgltgydffwivpslvsgntelipkefpsglisvsyddwdyslearvrdgigilt
taassmlekfsyipeakascygqmerpevpmhtlhpfmvnvtwdgkdlsfteegyqvhpr
lvvivlnkdrewekvgkwenhtlslrhavwpryksfsdcepddnhlsivtleeapfvive
didpltetcvrntvpcrkfvkinnstnegmnvkkcckgfcidilkklsrtvkftydlylv
tngkhgkkvnnvwngmigevvyqravmavgsltineersevvdfsvpfvetgisvmvsrs
ngtvspsaflepfsasvwvmmfvmllivsaiavfvfeyfspvgynrnlakgkaphgpsft
igkaiwllwglvfnnsvpvqnpkgttskimvsvwaffaviflasytanlaafmiqeefvd
qvtglsdkkfqrphdysppfrfgtvpngsternirnnypymhqymtkfnqkgvedalvsl
ktgkldafiydaavlnykagrdegcklvtigsgyifattgygialqkgspwkrqidlall
qfvgdgemeeletcwltgichneknevmssqldidnmagvfymlaaamalslitfiwehl
fyksraeakrmkg

    Sequence, based on observed residues (ATOM records):
    >7eosC (C:)
lniavmlghshdvterelrtlwgpeqaaglpldvnvvallmnrtdpkslithvcdlmsga
rihglvfgddtdqeavaqmldfisshtfvpilgihggasmimadkdptstffqfgasiqq
qatvmlkimqdydwhvfslvttifpgyrefisfvkttvdnsfvgwdmqnvitldtsfeda
ktqvqlkkihssvillycskdeavlilsearslgltgydffwivpslvsgntelipkefp
sglisvsyddwdyslearvrdgigilttaassmlekfsyipeakascygqmerpevpmht
lhpfmvnvtwdgkdlsfteegyqvhprlvvivlnkdrewekvgkwenhtlslrhavwpry
ksfsdcepddnhlsivtleeapfvivedidpltetcvrntvpcrkfvkinnstnegmnvk
kcckgfcidilkklsrtvkftydlylvtngkhgkkvnnvwngmigevvyqravmavgslt
ineersevvdfsvpfvetgisvmvsrsngflepfsasvwvmmfvmllivsaiavfvfeyf
spsftigkaiwllwglvfnnsvpvqnttskimvsvwaffaviflasytanlaafmiqdqv
tglsdkkfqrphdysppfrfgtvpngsternirnnypymhqymtkfnqkgvedalvslkt
gkldafiydaavlnykagrdegcklvtigsgyifattgygialqkgspwkrqidlallqf
vgdgemeeletcwltgichdidnmagvfymlaaamalslitfiw

  • Chain 'D':
    Sequence, based on SEQRES records:
    >7eosD (D:)
mstmrlltlallfscsvaraacdpkivnigavlstrkheqmfreavnqankrhgswkiql
natsvthkpnaiqmalsvcedlissqvyailvshpptpndhftptpvsytagfyripvlg
lttrmsiysdksihlsflrtvppyshqssvwfemmrvyswnhiillvsddhegraaqkrl
etlleereskaekvlqfdpgtknvtallmeakelearviilsaseddaatvyraaamlnm
tgsgyvwlvgereisgnalryapdgilglqlingknesahisdavgvvaqavhelleken
itdpprgcvgntniwktgplfkrvlmsskyadgvtgrvefnedgdrkfanysimnlqnrk
lvqvgiyngthvipndrkiiwpggetekprgyqmstrlkivtihqepfvyvkptlsdgtc
keeftvngdpvkkvictgpndtspgsprhtvpqccygfcidlliklartmnftyevhlva
dgkfgtqervnnsnkkewngmmgellsgqadmivapltinneraqyiefskpfkyqglti
lvkkeiprstldsfmqpfqstlwllvglsvhvvavmlylldrfspfgrfkvnseeeeeda
ltlssamwfswgvllnsgigegaprsfsarilgmvwagfamiivasytanlaaflvldrp
eeritgindprlrnpsdkfiyatvkqssvdiyfrrqvclstmyrhmekhnyesaaeaiqa
vrdnklhafiwdsavlefeasqkcdlvttgelffrsgfgigmrkdspwkqnvslsilksh
engfmedldktwvryqecdsrsnapatltfenmagvfmlvaggivagiflifieiaykrh
kdarrkq

    Sequence, based on observed residues (ATOM records):
    >7eosD (D:)
kivnigavlstrkheqmfreavnqankrhgswkiqlnatsvthkpnaiqmalsvcedlis
sqvyailvshpptpndhftptpvsytagfyripvlglttrmsiysdksihlsflrtvppy
shqssvwfemmrvyswnhiillvsddhegraaqkrletlleereskaekvlqfdpgtknv
tallmeakelearviilsaseddaatvyraaamlnmtgsgyvwlvgereisgnalryapd
gilglqlingknesahisdavgvvaqavhellekenitdpprgcvgntniwktgplfkrv
lmsskyadgvtgrvefnedgdrkfanysimnlqnrklvqvgiyngthvipndrkiiwpgg
etekprgyqmstrlkivtihqepfvyvkptlsdgtckeeftvngdpvkkvictgpndtsp
gsprhtvpqccygfcidlliklartmnftyevhlvadgkfgtqervnnsnkkewngmmge
llsgqadmivapltinneraqyiefskpfkyqgltilvkkeiprstldsfmqpfqstlwl
lvglsvhvvavmlylldrfsltlssamwfswgvllnsgigsfsarilgmvwagfamiiva
sytanlaaflvldrpeeritgindprlrnpsdkfiyatvkqssvdiyfrrqvclstmyrh
mekhnyesaaeaiqavrdnklhafiwdsavlefeasqkcdlvttgelffrsgfgigmrkd
spwkqnvslsilkshengfmedldktwvryqectfenmagvfmlvaggivagiflifiei
aykrhkdar