PDB entry 7eo2

View 7eo2 on RCSB PDB site
Description: Cryo-EM of Sphingosine 1-phosphate receptor 1 / Gi complex bound to FTY720p
Class: membrane protein
Keywords: gpcr, membrane protein
Deposited on 2021-04-21, released 2022-01-05
The last revision prior to the SCOPe 2.08 freeze date was dated 2022-01-05, with a file datestamp of 2021-12-31.
Experiment type: EM
Resolution: 2.89 Å
R-factor: N/A
AEROSPACI score: 0.24 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Sphingosine 1-phosphate receptor 1
    Species: Homo sapiens [TaxId:9606]
    Gene: S1PR1, CHEDG1, EDG1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P21453 (0-338)
      • conflict (132)
  • Chain 'B':
    Compound: Guanine nucleotide-binding protein G(i) subunit alpha-1
    Species: Homo sapiens [TaxId:9606]
    Gene: GNAI1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P63096 (0-353)
      • conflict (202)
      • conflict (325)
  • Chain 'C':
    Compound: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
    Species: Homo sapiens [TaxId:9606]
    Gene: GNB1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P62873 (6-344)
      • initiating methionine (0)
      • expression tag (1-5)
    Domains in SCOPe 2.08: d7eo2c_
  • Chain 'D':
    Compound: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2
    Species: Homo sapiens [TaxId:9606]
    Gene: GNG2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d7eo2d_
  • Chain 'E':
    Compound: scFv16
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 7EO2 (0-246)
    Domains in SCOPe 2.08: d7eo2e_
  • Heterogens: J89

PDB Chain Sequences:

  • Chain 'A':
    No sequence available.

  • Chain 'B':
    No sequence available.

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >7eo2C (C:)
mgsllqseldqlrqeaeqlknqirdarkacadatlsqitnnidpvgriqmrtrrtlrghl
akiyamhwgtdsrllvsasqdgkliiwdsyttnkvhaiplrsswvmtcayapsgnyvacg
gldnicsiynlktregnvrvsrelaghtgylsccrflddnqivtssgdttcalwdietgq
qtttftghtgdvmslslapdtrlfvsgacdasaklwdvregmcrqtftghesdinaicff
pngnafatgsddatcrlfdlradqelmtyshdniicgitsvsfsksgrlllagyddfncn
vwdalkadragvlaghdnrvsclgvtddgmavatgswdsflkiwn

    Sequence, based on observed residues (ATOM records): (download) 
    >7eo2C (C:)
ldqlrqeaeqlknqirdarkacadatlsqitnnidpvgriqmrtrrtlrghlakiyamhw
gtdsrllvsasqdgkliiwdsyttnkvhaiplrsswvmtcayapsgnyvacggldnicsi
ynlktregnvrvsrelaghtgylsccrflddnqivtssgdttcalwdietgqqtttftgh
tgdvmslslapdtrlfvsgacdasaklwdvregmcrqtftghesdinaicffpngnafat
gsddatcrlfdlradqelmtyshdniicgitsvsfsksgrlllagyddfncnvwdalkad
ragvlaghdnrvsclgvtddgmavatgswdsflkiwn

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >7eo2D (D:)
masnntasiaqarklveqlkmeanidrikvskaaadlmayceahakedplltpvpasenp
frekkffcail

    Sequence, based on observed residues (ATOM records): (download) 
    >7eo2D (D:)
ntasiaqarklveqlkmeanidrikvskaaadlmayceahakedplltpvpasenpfr

  • Chain 'E':
    Sequence, based on SEQRES records: (download) 
    >7eo2E (E:)
vqlvesggglvqpggsrklscsasgfafssfgmhwvrqapekglewvayissgsgtiyya
dtvkgrftisrddpkntlflqmtslrsedtamyycvrsiyyygsspfdfwgqgttltvsa
ggggsggggsggggssdivmtqatssvpvtpgesvsiscrssksllhsngntylywflqr
pgqspqlliyrmsnlasgvpdrfsgsgsgtaftltisrleaedvgvyycmqhleypltfg
agtklel

    Sequence, based on observed residues (ATOM records): (download) 
    >7eo2E (E:)
vqlvesggglvqpggsrklscsasgfafssfgmhwvrqapekglewvayissgsgtiyya
dtvkgrftisrddpkntlflqmtslrsedtamyycvrsiyyygsspfdfwgqgttltvss
divmtqatssvpvtpgesvsiscrssksllhsngntylywflqrpgqspqlliyrmsnla
sgvpdrfsgsgsgtaftltisrleaedvgvyycmqhleypltfgagtklel