PDB entry 7ekt

View 7ekt on RCSB PDB site
Description: human alpha 7 nicotinic acetylcholine receptor bound to evp-6124 and pnu-120596
Deposited on 2021-04-06, released 2021-05-19
The last revision was dated 2021-06-16, with a file datestamp of 2021-06-11.
Experiment type: EM
Resolution: 3.02 Å
R-factor: N/A
AEROSPACI score: 0.22 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Neuronal acetylcholine receptor subunit alpha-7
    Species: Homo sapiens [TaxId:9606]
    Gene: CHRNA7, NACHRA7
    Database cross-references and differences (RAF-indexed):
  • Chain 'B':
    Compound: Neuronal acetylcholine receptor subunit alpha-7
    Species: Homo sapiens [TaxId:9606]
    Gene: CHRNA7, NACHRA7
    Database cross-references and differences (RAF-indexed):
  • Chain 'C':
    Compound: Neuronal acetylcholine receptor subunit alpha-7
    Species: Homo sapiens [TaxId:9606]
    Gene: CHRNA7, NACHRA7
    Database cross-references and differences (RAF-indexed):
  • Chain 'D':
    Compound: Neuronal acetylcholine receptor subunit alpha-7
    Species: Homo sapiens [TaxId:9606]
    Gene: CHRNA7, NACHRA7
    Database cross-references and differences (RAF-indexed):
  • Chain 'E':
    Compound: Neuronal acetylcholine receptor subunit alpha-7
    Species: Homo sapiens [TaxId:9606]
    Gene: CHRNA7, NACHRA7
    Database cross-references and differences (RAF-indexed):
  • Heterogens: I33, I34, NAG, CLR

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >7ektA (A:)
mrcspggvwlalaasllhvslqgefqrklykelvknynplerpvandsqpltvyfslsll
qimdvdeknqvlttniwlqmswtdhylqwnvseypgvktvrfpdgqiwkpdillynsade
rfdatfhtnvlvnssghcqylppgifksscyidvrwfpfdvqhcklkfgswsyggwsldl
qmqeadisgyipngewdlvgipgkrserfyecckepypdvtftvtmrrrtlyyglnllip
cvlisalallvfllpadsgekislgitvllsltvfmllvaeimpatsdsvpliaqyfast
miivglsvvvtvivlqyhhhdpdggkmpkwtrvillnwcawflrmkrpgedkvrpacqhk
qrrcslasvemsavapppasngnllyigfrgldgvhcvptpdsgvvcgrmacspthdehl
lhggqppegdpdlakileevryianrfrcqdeseavcsewkfaacvvdrlclmafsvfti
ictigilmsapnfveavskdfa

    Sequence, based on observed residues (ATOM records):
    >7ektA (A:)
gefqrklykelvknynplerpvandsqpltvyfslsllqimdvdeknqvlttniwlqmsw
tdhylqwnvseypgvktvrfpdgqiwkpdillynsaderfdatfhtnvlvnssghcqylp
pgifksscyidvrwfpfdvqhcklkfgswsyggwsldlqmqeadisgyipngewdlvgip
gkrserfyecckepypdvtftvtmrrrtlyyglnllipcvlisalallvfllpadsgeki
slgitvllsltvfmllvaeimpatsdsvpliaqyfastmiivglsvvvtvivlqyhhhdp
dggkmpkwtrvillnwcawflrmkrdlakileevryianrfrcqdeseavcsewkfaacv
vdrlclmafsvftiictigilmsapnfveavskdfa

  • Chain 'B':
    Sequence, based on SEQRES records:
    >7ektB (B:)
mrcspggvwlalaasllhvslqgefqrklykelvknynplerpvandsqpltvyfslsll
qimdvdeknqvlttniwlqmswtdhylqwnvseypgvktvrfpdgqiwkpdillynsade
rfdatfhtnvlvnssghcqylppgifksscyidvrwfpfdvqhcklkfgswsyggwsldl
qmqeadisgyipngewdlvgipgkrserfyecckepypdvtftvtmrrrtlyyglnllip
cvlisalallvfllpadsgekislgitvllsltvfmllvaeimpatsdsvpliaqyfast
miivglsvvvtvivlqyhhhdpdggkmpkwtrvillnwcawflrmkrpgedkvrpacqhk
qrrcslasvemsavapppasngnllyigfrgldgvhcvptpdsgvvcgrmacspthdehl
lhggqppegdpdlakileevryianrfrcqdeseavcsewkfaacvvdrlclmafsvfti
ictigilmsapnfveavskdfa

    Sequence, based on observed residues (ATOM records):
    >7ektB (B:)
gefqrklykelvknynplerpvandsqpltvyfslsllqimdvdeknqvlttniwlqmsw
tdhylqwnvseypgvktvrfpdgqiwkpdillynsaderfdatfhtnvlvnssghcqylp
pgifksscyidvrwfpfdvqhcklkfgswsyggwsldlqmqeadisgyipngewdlvgip
gkrserfyecckepypdvtftvtmrrrtlyyglnllipcvlisalallvfllpadsgeki
slgitvllsltvfmllvaeimpatsdsvpliaqyfastmiivglsvvvtvivlqyhhhdp
dggkmpkwtrvillnwcawflrmkrdlakileevryianrfrcqdeseavcsewkfaacv
vdrlclmafsvftiictigilmsapnfveavskdfa

  • Chain 'C':
    Sequence, based on SEQRES records:
    >7ektC (C:)
mrcspggvwlalaasllhvslqgefqrklykelvknynplerpvandsqpltvyfslsll
qimdvdeknqvlttniwlqmswtdhylqwnvseypgvktvrfpdgqiwkpdillynsade
rfdatfhtnvlvnssghcqylppgifksscyidvrwfpfdvqhcklkfgswsyggwsldl
qmqeadisgyipngewdlvgipgkrserfyecckepypdvtftvtmrrrtlyyglnllip
cvlisalallvfllpadsgekislgitvllsltvfmllvaeimpatsdsvpliaqyfast
miivglsvvvtvivlqyhhhdpdggkmpkwtrvillnwcawflrmkrpgedkvrpacqhk
qrrcslasvemsavapppasngnllyigfrgldgvhcvptpdsgvvcgrmacspthdehl
lhggqppegdpdlakileevryianrfrcqdeseavcsewkfaacvvdrlclmafsvfti
ictigilmsapnfveavskdfa

    Sequence, based on observed residues (ATOM records):
    >7ektC (C:)
gefqrklykelvknynplerpvandsqpltvyfslsllqimdvdeknqvlttniwlqmsw
tdhylqwnvseypgvktvrfpdgqiwkpdillynsaderfdatfhtnvlvnssghcqylp
pgifksscyidvrwfpfdvqhcklkfgswsyggwsldlqmqeadisgyipngewdlvgip
gkrserfyecckepypdvtftvtmrrrtlyyglnllipcvlisalallvfllpadsgeki
slgitvllsltvfmllvaeimpatsdsvpliaqyfastmiivglsvvvtvivlqyhhhdp
dggkmpkwtrvillnwcawflrmkrdlakileevryianrfrcqdeseavcsewkfaacv
vdrlclmafsvftiictigilmsapnfveavskdfa

  • Chain 'D':
    Sequence, based on SEQRES records:
    >7ektD (D:)
mrcspggvwlalaasllhvslqgefqrklykelvknynplerpvandsqpltvyfslsll
qimdvdeknqvlttniwlqmswtdhylqwnvseypgvktvrfpdgqiwkpdillynsade
rfdatfhtnvlvnssghcqylppgifksscyidvrwfpfdvqhcklkfgswsyggwsldl
qmqeadisgyipngewdlvgipgkrserfyecckepypdvtftvtmrrrtlyyglnllip
cvlisalallvfllpadsgekislgitvllsltvfmllvaeimpatsdsvpliaqyfast
miivglsvvvtvivlqyhhhdpdggkmpkwtrvillnwcawflrmkrpgedkvrpacqhk
qrrcslasvemsavapppasngnllyigfrgldgvhcvptpdsgvvcgrmacspthdehl
lhggqppegdpdlakileevryianrfrcqdeseavcsewkfaacvvdrlclmafsvfti
ictigilmsapnfveavskdfa

    Sequence, based on observed residues (ATOM records):
    >7ektD (D:)
gefqrklykelvknynplerpvandsqpltvyfslsllqimdvdeknqvlttniwlqmsw
tdhylqwnvseypgvktvrfpdgqiwkpdillynsaderfdatfhtnvlvnssghcqylp
pgifksscyidvrwfpfdvqhcklkfgswsyggwsldlqmqeadisgyipngewdlvgip
gkrserfyecckepypdvtftvtmrrrtlyyglnllipcvlisalallvfllpadsgeki
slgitvllsltvfmllvaeimpatsdsvpliaqyfastmiivglsvvvtvivlqyhhhdp
dggkmpkwtrvillnwcawflrmkrdlakileevryianrfrcqdeseavcsewkfaacv
vdrlclmafsvftiictigilmsapnfveavskdfa

  • Chain 'E':
    Sequence, based on SEQRES records:
    >7ektE (E:)
mrcspggvwlalaasllhvslqgefqrklykelvknynplerpvandsqpltvyfslsll
qimdvdeknqvlttniwlqmswtdhylqwnvseypgvktvrfpdgqiwkpdillynsade
rfdatfhtnvlvnssghcqylppgifksscyidvrwfpfdvqhcklkfgswsyggwsldl
qmqeadisgyipngewdlvgipgkrserfyecckepypdvtftvtmrrrtlyyglnllip
cvlisalallvfllpadsgekislgitvllsltvfmllvaeimpatsdsvpliaqyfast
miivglsvvvtvivlqyhhhdpdggkmpkwtrvillnwcawflrmkrpgedkvrpacqhk
qrrcslasvemsavapppasngnllyigfrgldgvhcvptpdsgvvcgrmacspthdehl
lhggqppegdpdlakileevryianrfrcqdeseavcsewkfaacvvdrlclmafsvfti
ictigilmsapnfveavskdfa

    Sequence, based on observed residues (ATOM records):
    >7ektE (E:)
gefqrklykelvknynplerpvandsqpltvyfslsllqimdvdeknqvlttniwlqmsw
tdhylqwnvseypgvktvrfpdgqiwkpdillynsaderfdatfhtnvlvnssghcqylp
pgifksscyidvrwfpfdvqhcklkfgswsyggwsldlqmqeadisgyipngewdlvgip
gkrserfyecckepypdvtftvtmrrrtlyyglnllipcvlisalallvfllpadsgeki
slgitvllsltvfmllvaeimpatsdsvpliaqyfastmiivglsvvvtvivlqyhhhdp
dggkmpkwtrvillnwcawflrmkrdlakileevryianrfrcqdeseavcsewkfaacv
vdrlclmafsvftiictigilmsapnfveavskdfa