PDB entry 7e9b

View 7e9b on RCSB PDB site
Description: Structural basis of HLX10 PD-1 receptor recognition, a promising anti-PD-1 antibody clinical candidate for cancer immunotherapy
Class: immune system
Keywords: Antibody, mAb, PD-1, PD-L-1, Cancer, T-cell, Immunotherapy, ICI, IMMUNE SYSTEM
Deposited on 2021-03-04, released 2021-07-28
The last revision prior to the SCOPe 2.08 freeze date was dated 2021-07-28, with a file datestamp of 2021-07-23.
Experiment type: XRAY
Resolution: 1.78 Å
R-factor: N/A
AEROSPACI score: 0.44 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'C':
    Compound: Programmed cell death protein 1
    Species: Homo sapiens [TaxId:9606]
    Gene: Pdcd1, Pd1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d7e9bc_
  • Chain 'H':
    Compound: heavy chain of Fab fragment of HLX10
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 7E9B (0-214)
    Domains in SCOPe 2.08: d7e9bh_
  • Chain 'L':
    Compound: light chain of Fab fragment of HLX10
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 7E9B (0-213)
    Domains in SCOPe 2.08: d7e9bl_
  • Heterogens: HOH

PDB Chain Sequences:

  • Chain 'C':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >7e9bC (C:)
wnpptfspallvvtegdnatftcsfsntsesfvlnwyrmspsnqtdklaafpedrsqpgq
dcrfrvtqlpngrdfhmsvvrarrndsgtylcgaislapkaqikeslraelrvte

  • Chain 'H':
    Sequence, based on SEQRES records: (download) 
    >7e9bH (H:)
qvqlvesggglvkpggslrlscaasgftfsnygmswirqapgkglewvstisgggsniyy
adsvkgrftisrdnaknslylqmnslraedtavyycvsyyygidfwgqgtsvtvssastk
gpsvfplapcsrstsestaalgclvkdyfpepvtvswnsgaltsgvhtfpavlqssglys
lssvvtvpssslgtktytcnvdhkpsntkvdkrve

    Sequence, based on observed residues (ATOM records): (download) 
    >7e9bH (H:)
qvqlvesggglvkpggslrlscaasgftfsnygmswirqapgkglewvstisgggsniyy
adsvkgrftisrdnaknslylqmnslraedtavyycvsyyygidfwgqgtsvtvssastk
gpsvfplapestaalgclvkdyfpepvtvswnsgaltsgvhtfpavlqssglyslssvvt
vpssslgtktytcnvdhkpsntkvdkrve

  • Chain 'L':
    Sequence, based on SEQRES records: (download) 
    >7e9bL (L:)
diqmtqspsslsasvgdrvtitckasqdvttavawyqqkpgkapklliywastrhtgvps
rfsgsgsgtdftltisslqpedfatyycqqhytipwtfgggtkleikrtvaapsvfifpp
sdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstyslsstlt
lskadyekhkvyacevthqglsspvtksfnrgec

    Sequence, based on observed residues (ATOM records): (download) 
    >7e9bL (L:)
diqmtqspsslsasvgdrvtitckasqdvttavawyqqkpgkapklliywastrhtgvps
rfsgsgsgtdftltisslqpedfatyycqqhytipwtfgggtkleikrtvaapsvfifpp
sdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstyslsstlt
lskadyekhkvyacevthqglsspvtksfnrg