PDB entry 7e2e

View 7e2e on RCSB PDB site
Description: crystal structure of the estrogen-related receptor alpha (erralpha) ligand-binding domain (lbd) in complex with an agonist ds45500853 and a pgc-1alpha peptide
Deposited on 2021-02-05, released 2021-06-30
The last revision was dated 2021-06-30, with a file datestamp of 2021-06-25.
Experiment type: XRAY
Resolution: 2.7 Å
R-factor: N/A
AEROSPACI score: 0.22 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Steroid hormone receptor ERR1
    Species: Homo sapiens [TaxId:9606]
    Gene: ESRRA, ERR1, ESRL1, NR3B1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P11474 (15-244)
      • expression tag (14)
  • Chain 'B':
    Compound: Steroid hormone receptor ERR1
    Species: Homo sapiens [TaxId:9606]
    Gene: ESRRA, ERR1, ESRL1, NR3B1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P11474 (15-244)
      • expression tag (14)
  • Chain 'P':
    Compound: Peroxisome proliferator-activated receptor gamma coactivator 1-alpha
    Species: HOMO SAPIENS, synthetic [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q9UBK2 (0-11)
      • engineered mutation (2)
  • Chain 'Q':
    Compound: Peroxisome proliferator-activated receptor gamma coactivator 1-alpha
    Species: HOMO SAPIENS, synthetic [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q9UBK2 (0-11)
      • engineered mutation (2)
  • Heterogens: HVO, IOD, HOH

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >7e2eA (A:)
mrgshhhhhhgipefvnalvshllvvepeklyampdpagpdghlpavatlcdlfdreivv
tiswaksipgfsslslsdqmsvlqsvwmevlvlgvaqrslplqdelafaedlvldeegar
aaglgelgaallqlvrrlqalrlereeyvllkalalansdsvhiedaeaveqlrealhea
lleyeagragpgggaerrragrllltlpllrqtagkvlahfygvklegkvpmhklfleml
eammd

    Sequence, based on observed residues (ATOM records):
    >7e2eA (A:)
fvnalvshllvvepeklyampdhlpavatlcdlfdreivvtiswaksipgfsslslsdqm
svlqsvwmevlvlgvaqrslplqdelafaedlvldeegaraaglgelgaallqlvrrlqa
lrlereeyvllkalalansdsvhiedaeaveqlrealhealleyeagrrragrllltlpl
lrqtagkvlahfygvklegkvpmhklflemleammd

  • Chain 'B':
    Sequence, based on SEQRES records:
    >7e2eB (B:)
mrgshhhhhhgipefvnalvshllvvepeklyampdpagpdghlpavatlcdlfdreivv
tiswaksipgfsslslsdqmsvlqsvwmevlvlgvaqrslplqdelafaedlvldeegar
aaglgelgaallqlvrrlqalrlereeyvllkalalansdsvhiedaeaveqlrealhea
lleyeagragpgggaerrragrllltlpllrqtagkvlahfygvklegkvpmhklfleml
eammd

    Sequence, based on observed residues (ATOM records):
    >7e2eB (B:)
fvnalvshllvvepeklyampdhlpavatlcdlfdreivvtiswaksipgfsslslsdqm
svlqsvwmevlvlgvaqrslplqdelafaedlvldeegaraaglgelgaallqlvrrlqa
lrlereeyvllkalalansdsvhiedaeaveqlrealhealleyeagrrragrllltlpl
lrqtagkvlahfygvklegkvpmhklflemleammd

  • Chain 'P':
    Sequence; same for both SEQRES and ATOM records:
    >7e2eP (P:)
rpasellkyltt

  • Chain 'Q':
    Sequence; same for both SEQRES and ATOM records:
    >7e2eQ (Q:)
rpasellkyltt