PDB entry 7e0f

View 7e0f on RCSB PDB site
Description: CryoEM structure of G51D alpha-synuclein amyloid fibril
Class: protein fibril
Keywords: amyloid fibril, PROTEIN FIBRIL
Deposited on 2021-01-27, released 2021-10-06
The last revision prior to the SCOPe 2.08 freeze date was dated 2021-10-06, with a file datestamp of 2021-10-01.
Experiment type: EM
Resolution: 3.02 Å
R-factor: N/A
AEROSPACI score: 0.1 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Alpha-synuclein
    Species: Homo sapiens [TaxId:9606]
    Gene: SNCA, NACP, PARK1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P37840 (0-139)
      • engineered mutation (50)
    Domains in SCOPe 2.08: d7e0fa_
  • Chain 'B':
    Compound: Alpha-synuclein
    Species: Homo sapiens [TaxId:9606]
    Gene: SNCA, NACP, PARK1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P37840 (0-139)
      • engineered mutation (50)
    Domains in SCOPe 2.08: d7e0fb_
  • Chain 'C':
    Compound: Alpha-synuclein
    Species: Homo sapiens [TaxId:9606]
    Gene: SNCA, NACP, PARK1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P37840 (0-139)
      • engineered mutation (50)
    Domains in SCOPe 2.08: d7e0fc_
  • Chain 'D':
    Compound: Alpha-synuclein
    Species: Homo sapiens [TaxId:9606]
    Gene: SNCA, NACP, PARK1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P37840 (0-139)
      • engineered mutation (50)
    Domains in SCOPe 2.08: d7e0fd_
  • Chain 'E':
    Compound: Alpha-synuclein
    Species: Homo sapiens [TaxId:9606]
    Gene: SNCA, NACP, PARK1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P37840 (0-139)
      • engineered mutation (50)
    Domains in SCOPe 2.08: d7e0fe_
  • Chain 'F':
    Compound: Alpha-synuclein
    Species: Homo sapiens [TaxId:9606]
    Gene: SNCA, NACP, PARK1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P37840 (0-139)
      • engineered mutation (50)
    Domains in SCOPe 2.08: d7e0ff_

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >7e0fA (A:)
mdvfmkglskakegvvaaaektkqgvaeaagktkegvlyvgsktkegvvhdvatvaektk
eqvtnvggavvtgvtavaqktvegagsiaaatgfvkkdqlgkneegapqegiledmpvdp
dneayempseegyqdyepea

    Sequence, based on observed residues (ATOM records): (download) 
    >7e0fA (A:)
hdvatvaektkeqvtnvggavvtgvtavaqktvegagsiaaatgfvkkd

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >7e0fB (B:)
mdvfmkglskakegvvaaaektkqgvaeaagktkegvlyvgsktkegvvhdvatvaektk
eqvtnvggavvtgvtavaqktvegagsiaaatgfvkkdqlgkneegapqegiledmpvdp
dneayempseegyqdyepea

    Sequence, based on observed residues (ATOM records): (download) 
    >7e0fB (B:)
hdvatvaektkeqvtnvggavvtgvtavaqktvegagsiaaatgfvkkd

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >7e0fC (C:)
mdvfmkglskakegvvaaaektkqgvaeaagktkegvlyvgsktkegvvhdvatvaektk
eqvtnvggavvtgvtavaqktvegagsiaaatgfvkkdqlgkneegapqegiledmpvdp
dneayempseegyqdyepea

    Sequence, based on observed residues (ATOM records): (download) 
    >7e0fC (C:)
hdvatvaektkeqvtnvggavvtgvtavaqktvegagsiaaatgfvkkd

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >7e0fD (D:)
mdvfmkglskakegvvaaaektkqgvaeaagktkegvlyvgsktkegvvhdvatvaektk
eqvtnvggavvtgvtavaqktvegagsiaaatgfvkkdqlgkneegapqegiledmpvdp
dneayempseegyqdyepea

    Sequence, based on observed residues (ATOM records): (download) 
    >7e0fD (D:)
hdvatvaektkeqvtnvggavvtgvtavaqktvegagsiaaatgfvkkd

  • Chain 'E':
    Sequence, based on SEQRES records: (download) 
    >7e0fE (E:)
mdvfmkglskakegvvaaaektkqgvaeaagktkegvlyvgsktkegvvhdvatvaektk
eqvtnvggavvtgvtavaqktvegagsiaaatgfvkkdqlgkneegapqegiledmpvdp
dneayempseegyqdyepea

    Sequence, based on observed residues (ATOM records): (download) 
    >7e0fE (E:)
hdvatvaektkeqvtnvggavvtgvtavaqktvegagsiaaatgfvkkd

  • Chain 'F':
    Sequence, based on SEQRES records: (download) 
    >7e0fF (F:)
mdvfmkglskakegvvaaaektkqgvaeaagktkegvlyvgsktkegvvhdvatvaektk
eqvtnvggavvtgvtavaqktvegagsiaaatgfvkkdqlgkneegapqegiledmpvdp
dneayempseegyqdyepea

    Sequence, based on observed residues (ATOM records): (download) 
    >7e0fF (F:)
hdvatvaektkeqvtnvggavvtgvtavaqktvegagsiaaatgfvkkd