PDB entry 7dzn

View 7dzn on RCSB PDB site
Description: Crystal Structure of the cross-restricted T18A TCR and HLAB4201 bound to HIV-1 Gag TL9 peptide
Class: immune system
Keywords: TCR and p-MHC complex, HIV epitope TL9, IMMUNE SYSTEM
Deposited on 2021-01-25, released 2022-01-26
The last revision prior to the SCOPe 2.08 freeze date was dated 2022-01-26, with a file datestamp of 2022-01-21.
Experiment type: XRAY
Resolution: 2.63 Å
R-factor: N/A
AEROSPACI score: 0.25 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: MHC class I antigen
    Species: Homo sapiens [TaxId:9606]
    Gene: HLA-B
    Database cross-references and differences (RAF-indexed):
    • Uniprot V6E0U6 (2-278)
      • expression tag (0-1)
    Domains in SCOPe 2.08: d7dzna1, d7dzna2
  • Chain 'B':
    Compound: Beta-2-microglobulin
    Species: Homo sapiens [TaxId:9606]
    Gene: B2M, CDABP0092, HDCMA22P
    Database cross-references and differences (RAF-indexed):
    • Uniprot P61769 (1-99)
      • expression tag (0)
    Domains in SCOPe 2.08: d7dznb1, d7dznb2
  • Chain 'C':
    Compound: Gag-Pol polyprotein
    Species: Human immunodeficiency virus 1 [TaxId:11676]
    Database cross-references and differences (RAF-indexed):
  • Chain 'D':
    Compound: beta chain T18A TCR
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 7DZN (0-243)
    Domains in SCOPe 2.08: d7dznd1, d7dznd2
  • Chain 'E':
    Compound: alpha chain T18A TCR
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 7DZN (0-203)
    Domains in SCOPe 2.08: d7dzne1, d7dzne2
  • Heterogens: HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >7dznA (A:)
mggshsmryfytsvsrpgrgeprfisvgyvddtqfvrfdsdaaspreeprapwieqegpe
ywdrntqiykaqaqtdreslrnlrgyynqseagshtlqsmygcdvgpdgrllrghnqyay
dgkdyialnedlrswtaadtaaqitqrkweaarvaeqdraylegtcvewlrrylengkdt
leradppkthvthhpisdheatlrcwalgfypaeitltwqrdgedqtqdtelvetrpagd
rtfqkwaavvvpsgeeqrytchvqheglpkpltlrweps

    Sequence, based on observed residues (ATOM records): (download) 
    >7dznA (A:)
gshsmryfytsvsrpgrgeprfisvgyvddtqfvrfdsdaaspreeprapwieqegpeyw
drntqiykaqaqtdreslrnlrgyynqseagshtlqsmygcdvgpdgrllrghnqyaydg
kdyialnedlrswtaadtaaqitqrkweaarvaeqdraylegtcvewlrrylengkdtle
radppkthvthhpisdheatlrcwalgfypaeitltwqrdgedqtqdtelvetrpagdrt
fqkwaavvvpsgeeqrytchvqheglpkpltlrweps

  • Chain 'B':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >7dznB (B:)
miqrtpkiqvysrhpaengksnflncyvsgfhpsdievdllkngeriekvehsdlsfskd
wsfyllyyteftptekdeyacrvnhvtlsqpkivkwdrdm

  • Chain 'C':
    No sequence available.

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >7dznD (D:)
mgdagviqsprhevtemgqevtlrckpisghnslfwyrqtmmrglelliyfnnnvpidds
gmpedrfsakmpnasfstlkiqpseprdsavyfcasslgidaiyfgegswltvvedlknv
fppevavfepseaeishtqkatlvclatgfypdhvelswwvngkevhsgvctdpqplkeq
palndsryalssrlrvsatfwqnprnhfrcqvqfyglsendewtqdrakpvtqivsaeaw
grad

    Sequence, based on observed residues (ATOM records): (download) 
    >7dznD (D:)
agviqsprhevtemgqevtlrckpisghnslfwyrqtmmrglelliyfnnnvpiddsgmp
edrfsakmpnasfstlkiqpseprdsavyfcasslgidaiyfgegswltvvedlknvfpp
evavfepseaeishtqkatlvclatgfypdhvelswwvngkevhsgvctdpqplkeqpal
ndsryalssrlrvsatfwqnprnhfrcqvqfyglsendewtqdrakpvtqivsaeawgra
d

  • Chain 'E':
    Sequence, based on SEQRES records: (download) 
    >7dznE (E:)
mgdakttqppsmdcaegraanlpcnhstisgneyvywyrqihsqgpqyiihglknnetne
masliitedrksstlilphatlrdtavyycivrglnnagnmltfgggtrlmvkpdiqnpd
pavyqlrdskssdksvclftdfdsqtnvsqskdsdvyitdkcvldmrsmdfksnsavaws
nksdfacanafnnsiipedtffps

    Sequence, based on observed residues (ATOM records): (download) 
    >7dznE (E:)
dakttqppsmdcaegraanlpcnhstisgneyvywyrqihsqgpqyiihglknnetnema
sliitedrksstlilphatlrdtavyycivrglnnagnmltfgggtrlmvkpdiqnpdpa
vyqlrdskssdksvclftdfdsqtnvsqskdsdvyitdkcvldmrsmdfksnsavawsnk
sdfacanafnnsiipedtffps