PDB entry 7dsx

View 7dsx on RCSB PDB site
Description: structure of a human nhe1-chp1 complex under ph 7.5, bound by cariporide
Deposited on 2021-01-03, released 2021-06-23
The last revision was dated 2021-06-23, with a file datestamp of 2021-06-18.
Experiment type: EM
Resolution: 3.5 Å
R-factor: N/A
AEROSPACI score: 0.15 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: sodium/hydrogen exchanger 1
    Species: Homo sapiens [TaxId:9606]
    Gene: SLC9A1, APNH1, NHE1
    Database cross-references and differences (RAF-indexed):
  • Chain 'B':
    Compound: sodium/hydrogen exchanger 1
    Species: Homo sapiens [TaxId:9606]
    Gene: SLC9A1, APNH1, NHE1
    Database cross-references and differences (RAF-indexed):
  • Chain 'C':
    Compound: Calcineurin B homologous protein 1
    Species: Homo sapiens [TaxId:9606]
    Gene: CHP1, CHP
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q99653 (0-184)
      • engineered mutation (160)
  • Chain 'D':
    Compound: Calcineurin B homologous protein 1
    Species: Homo sapiens [TaxId:9606]
    Gene: CHP1, CHP
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q99653 (0-184)
      • engineered mutation (160)
  • Heterogens: HG0, PGT

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence; same for both SEQRES and ATOM records:
    >7dsxA (A:)
prkafpvlgidythvrtpfeislwillaclmkigfhviptissivpescllivvgllvgg
likgvgetppflqsdvfflfllppiildagyflplrqftenlgtilifavvgtlwnaffl
gglmyavclvggeqinniglldnllfgsiisavdpvavlavfeeihinellhilvfgesl
lndavtvvlyhlfeefanyehvgivdiflgflsffvvalggvlvgvvygviaaftsrfts
hirvieplfvflysymaylsaelfhlsgimaliasgvvmrpyveanishkshttikyflk
mwssvsetlififlgvstvagshhwnwtfvistllfcliarvlgvlgltwfinkfrivkl
tpkdqfiiaygglrgaiafslgylldkkhfpmcdlfltaiitvifftvfvqgmtirplvd
llavkkkqetkrsineeihtqfldhlltgiedicghyghhhwkdklnrfnkkyvkkclia
gerskepqliafyhkmemkqaielvesgg

  • Chain 'B':
    Sequence; same for both SEQRES and ATOM records:
    >7dsxB (B:)
prkafpvlgidythvrtpfeislwillaclmkigfhviptissivpescllivvgllvgg
likgvgetppflqsdvfflfllppiildagyflplrqftenlgtilifavvgtlwnaffl
gglmyavclvggeqinniglldnllfgsiisavdpvavlavfeeihinellhilvfgesl
lndavtvvlyhlfeefanyehvgivdiflgflsffvvalggvlvgvvygviaaftsrfts
hirvieplfvflysymaylsaelfhlsgimaliasgvvmrpyveanishkshttikyflk
mwssvsetlififlgvstvagshhwnwtfvistllfcliarvlgvlgltwfinkfrivkl
tpkdqfiiaygglrgaiafslgylldkkhfpmcdlfltaiitvifftvfvqgmtirplvd
llavkkkqetkrsineeihtqfldhlltgiedicghyghhhwkdklnrfnkkyvkkclia
gerskepqliafyhkmemkqaielvesgg

  • Chain 'C':
    Sequence; same for both SEQRES and ATOM records:
    >7dsxC (C:)
deeleeikketgfshsqitrlysrftsldkgengtlsredfqripelainplgdriinaf
fpegedqvnfrgfmrtlahfrpiednekskdvngpeplnsrsnklhfafrlydldkdeki
srdellqvlrmmvgvnisdeqlgsiadrtiqeadqdgdsaasftefvkvlekvdveqkms
irflh

  • Chain 'D':
    Sequence; same for both SEQRES and ATOM records:
    >7dsxD (D:)
deeleeikketgfshsqitrlysrftsldkgengtlsredfqripelainplgdriinaf
fpegedqvnfrgfmrtlahfrpiednekskdvngpeplnsrsnklhfafrlydldkdeki
srdellqvlrmmvgvnisdeqlgsiadrtiqeadqdgdsaasftefvkvlekvdveqkms
irflh