PDB entry 7dj2

View 7dj2 on RCSB PDB site
Description: Crystal structure of the G26C/E290S mutant of LeuT
Class: transport protein
Keywords: Neurotransmitter transporter, NSS, SLC6, TRANSPORT PROTEIN
Deposited on 2020-11-19, released 2021-04-07
The last revision prior to the SCOPe 2.08 freeze date was dated 2021-07-21, with a file datestamp of 2021-07-16.
Experiment type: XRAY
Resolution: 2.4 Å
R-factor: N/A
AEROSPACI score: 0.32 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Na(+):neurotransmitter symporter (Snf family)
    Species: Aquifex aeolicus [TaxId:63363]
    Database cross-references and differences (RAF-indexed):
    • Uniprot O67854 (0-512)
      • engineered mutation (25)
      • engineered mutation (289)
    Domains in SCOPe 2.08: d7dj2a_
  • Chain 'B':
    Compound: Na(+):neurotransmitter symporter (Snf family)
    Species: Aquifex aeolicus [TaxId:63363]
    Database cross-references and differences (RAF-indexed):
    • Uniprot O67854 (0-512)
      • engineered mutation (25)
      • engineered mutation (289)
    Domains in SCOPe 2.08: d7dj2b_
  • Heterogens: LEU, NA, BOG, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >7dj2A (A:)
    mevkrehwatrlglilamagnavglcnflrfpvqaaengggafmipyiiafllvgiplmw
    iewamgryggaqghgttpaifyllwrnrfakilgvfglwiplvvaiyyvyieswtlgfai
    kflvglvpepppnatdpdsilrpfkeflysyigvpkgdepilkpslfayivflitmfinv
    silirgiskgierfakiamptlfilavflvirvflletpngtaadglnflwtpdfeklkd
    pgvwiaavgqifftlslgfgaiityasyvrkdqdivlsgltaatlnekasvilggsisip
    aavaffgvanavaiakagafnlgfitlpaifsqtaggtflgflwffllffagltssiaim
    qpmiafledelklsrkhavlwtaaivffsahlvmflnksldemdfwagtigvvffgltel
    iiffwifgadkaweeinrggiikvpriyyyvmryitpaflavllvvwareyipkimeeth
    wtvwitrfyiiglflfltflvflaerrrnhesa
    

    Sequence, based on observed residues (ATOM records): (download)
    >7dj2A (A:)
    rehwatrlglilamagnavglcnflrfpvqaaengggafmipyiiafllvgiplmwiewa
    mgryggaqghgttpaifyllwrnrfakilgvfglwiplvvaiyyvyieswtlgfaikflv
    glvpepppnatdpdsilrpfkeflysyigvpkgdepilkpslfayivflitmfinvsili
    rgiskgierfakiamptlfilavflvirvflletpngtaadglnflwtpdfeklkdpgvw
    iaavgqifftlslgfgaiityasyvrkdqdivlsgltaatlnekasvilggsisipaava
    ffgvanavaiakagafnlgfitlpaifsqtaggtflgflwffllffagltssiaimqpmi
    afledelklsrkhavlwtaaivffsahlvmflnksldemdfwagtigvvffglteliiff
    wifgadkaweeinrggiikvpriyyyvmryitpaflavllvvwhwtvwitrfyiiglflf
    ltflvflaerrr
    

  • Chain 'B':
    Sequence, based on SEQRES records: (download)
    >7dj2B (B:)
    mevkrehwatrlglilamagnavglcnflrfpvqaaengggafmipyiiafllvgiplmw
    iewamgryggaqghgttpaifyllwrnrfakilgvfglwiplvvaiyyvyieswtlgfai
    kflvglvpepppnatdpdsilrpfkeflysyigvpkgdepilkpslfayivflitmfinv
    silirgiskgierfakiamptlfilavflvirvflletpngtaadglnflwtpdfeklkd
    pgvwiaavgqifftlslgfgaiityasyvrkdqdivlsgltaatlnekasvilggsisip
    aavaffgvanavaiakagafnlgfitlpaifsqtaggtflgflwffllffagltssiaim
    qpmiafledelklsrkhavlwtaaivffsahlvmflnksldemdfwagtigvvffgltel
    iiffwifgadkaweeinrggiikvpriyyyvmryitpaflavllvvwareyipkimeeth
    wtvwitrfyiiglflfltflvflaerrrnhesa
    

    Sequence, based on observed residues (ATOM records): (download)
    >7dj2B (B:)
    rehwatrlglilamagnavglcnflrfpvqaaengggafmipyiiafllvgiplmwiewa
    mgryggaqghgttpaifyllwrnrfakilgvfglwiplvvaiyyvyieswtlgfaikflv
    glvpeppatdpdsilrpfkeflysyigvpkgdepilkpslfayivflitmfinvsilirg
    iskgierfakiamptlfilavflvirvflletpngtaadglnflwtpdfeklkdpgvwia
    avgqifftlslgfgaiityasyvrkdqdivlsgltaatlnekasvilggsisipaavaff
    gvanavaiakagafnlgfitlpaifsqtaggtflgflwffllffagltssiaimqpmiaf
    ledelklsrkhavlwtaaivffsahlvmflnksldemdfwagtigvvffglteliiffwi
    fgadkaweeinrggiikvpriyyyvmryitpaflavllvvwarethwtvwitrfyiiglf
    lfltflvflaerrr