PDB entry 7dhz

View 7dhz on RCSB PDB site
Description: Arsenic-bound p53 DNA-binding domain mutant R249S
Class: transcription
Keywords: tumour suppressor, transcription factor, TRANSCRIPTION
Deposited on 2020-11-18, released 2021-03-03
The last revision prior to the SCOPe 2.08 freeze date was dated 2021-03-03, with a file datestamp of 2021-02-26.
Experiment type: XRAY
Resolution: 1.74 Å
R-factor: N/A
AEROSPACI score: 0.47 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Cellular tumor antigen p53
    Species: Homo sapiens [TaxId:9606]
    Gene: TP53, P53
    Database cross-references and differences (RAF-indexed):
    • Uniprot P04637
      • engineered mutation (155)
    Domains in SCOPe 2.08: d7dhza_
  • Chain 'B':
    Compound: Cellular tumor antigen p53
    Species: Homo sapiens [TaxId:9606]
    Gene: TP53, P53
    Database cross-references and differences (RAF-indexed):
    • Uniprot P04637
      • engineered mutation (155)
    Domains in SCOPe 2.08: d7dhzb_
  • Heterogens: ARS, GOL, ZN, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >7dhzA (A:)
sssvpsqktyqgsygfrlgflhsgtaksvtctyspalnkmfcqlaktcpvqlwvdstppp
gtrvramaiykqsqhmtevvrrcphhercsdsdglappqhlirvegnlrveylddrntfr
hsvvvpyeppevgsdcttihynymcnsscmggmnrspiltiitledssgnllgrnsfevr
vcacpgrdrrteeenlrkkg

    Sequence, based on observed residues (ATOM records): (download) 
    >7dhzA (A:)
vpsqktyqgsygfrlgflhsgtaksvtctyspalnkmfcqlaktcpvqlwvdstpppgtr
vramaiykqsqhmtevvrrcphhercsdsdglappqhlirvegnlrveylddrntfrhsv
vvpyeppevgsdcttihynymcnsscmggmnrspiltiitledssgnllgrnsfevrvca
cpgrdrrteeenl

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >7dhzB (B:)
sssvpsqktyqgsygfrlgflhsgtaksvtctyspalnkmfcqlaktcpvqlwvdstppp
gtrvramaiykqsqhmtevvrrcphhercsdsdglappqhlirvegnlrveylddrntfr
hsvvvpyeppevgsdcttihynymcnsscmggmnrspiltiitledssgnllgrnsfevr
vcacpgrdrrteeenlrkkg

    Sequence, based on observed residues (ATOM records): (download) 
    >7dhzB (B:)
vpsqktyqgsygfrlgflhsgtaksvtctyspalnkmfcqlaktcpvqlwvdstpppgtr
vramaiykqsqhmtevvrrcphhercsdsdglappqhlirvegnlrveylddrntfrhsv
vvpyeppevgsdcttihynymcnsscrspiltiitledssgnllgrnsfevrvcacpgrd
rrteeenlr