PDB entry 7dcs

View 7dcs on RCSB PDB site
Description: Crystal structure of HSF1 DNA-binding domain in complex with 3-site HSE DNA (23 bp)
Class: DNA binding protein/DNA
Keywords: DNA binding protein-DNA complex
Deposited on 2020-10-27, released 2021-07-14
The last revision prior to the SCOPe 2.08 freeze date was dated 2021-07-14, with a file datestamp of 2021-07-09.
Experiment type: XRAY
Resolution: 2.4 Å
R-factor: N/A
AEROSPACI score: 0.3 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Heat shock factor protein 1
    Species: Homo sapiens [TaxId:9606]
    Gene: HSF1, HSTF1
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q00613 (7-112)
      • expression tag (0-6)
    Domains in SCOPe 2.08: d7dcsa1, d7dcsa2
  • Chain 'B':
    Compound: Heat shock factor protein 1
    Species: Homo sapiens [TaxId:9606]
    Gene: HSF1, HSTF1
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q00613 (7-112)
      • expression tag (0-6)
    Domains in SCOPe 2.08: d7dcsb1, d7dcsb2
  • Chain 'C':
    Compound: Heat shock factor protein 1
    Species: Homo sapiens [TaxId:9606]
    Gene: HSF1, HSTF1
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q00613 (7-112)
      • expression tag (0-6)
    Domains in SCOPe 2.08: d7dcsc1, d7dcsc2
  • Chain 'D':
    Compound: Heat shock factor protein 1
    Species: Homo sapiens [TaxId:9606]
    Gene: HSF1, HSTF1
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q00613 (7-112)
      • expression tag (0-6)
    Domains in SCOPe 2.08: d7dcsd1, d7dcsd2
  • Chain 'E':
    Compound: Heat shock factor protein 1
    Species: Homo sapiens [TaxId:9606]
    Gene: HSF1, HSTF1
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q00613 (7-112)
      • expression tag (0-6)
    Domains in SCOPe 2.08: d7dcse_
  • Chain 'F':
    Compound: Heat shock factor protein 1
    Species: Homo sapiens [TaxId:9606]
    Gene: HSF1, HSTF1
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q00613 (7-112)
      • expression tag (0-6)
    Domains in SCOPe 2.08: d7dcsf_
  • Chain 'G':
    Compound: DNA (5'-d(*tp*gp*gp*cp*gp*tp*tp*cp*tp*ap*gp*ap*ap*tp*ap*tp*tp*cp*gp*cp*gp*gp*a)-3')
    Species: Homo sapiens [TaxId:9606]
  • Chain 'H':
    Compound: DNA (5'-d(*ap*tp*cp*cp*gp*cp*gp*ap*ap*tp*ap*tp*tp*cp*tp*ap*gp*ap*ap*cp*gp*cp*c)-3')
    Species: Homo sapiens [TaxId:9606]
  • Chain 'I':
    Compound: DNA (5'-d(*tp*gp*gp*cp*gp*tp*tp*cp*tp*ap*gp*ap*ap*tp*ap*tp*tp*cp*gp*cp*gp*gp*a)-3')
    Species: Homo sapiens [TaxId:9606]
  • Chain 'J':
    Compound: DNA (5'-d(*ap*tp*cp*cp*gp*cp*gp*ap*ap*tp*ap*tp*tp*cp*tp*ap*gp*ap*ap*cp*gp*cp*c)-3')
    Species: Homo sapiens [TaxId:9606]
  • Heterogens: NA, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >7dcsA (A:)
ghhhhhhvpafltklwtlvsdpdtdalicwspsgnsfhvfdqgqfakevlpkyfkhnnma
sfvrqlnmygfrkvvhieqgglvkperddtefqhpcflrgqeqllenikrkvt

    Sequence, based on observed residues (ATOM records): (download) 
    >7dcsA (A:)
hvpafltklwtlvsdpdtdalicwspsgnsfhvfdqgqfakevlpkyfkhnnmasfvrql
nmygfrkvvhddtefqhpcflrgqeqllenikrkv

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >7dcsB (B:)
ghhhhhhvpafltklwtlvsdpdtdalicwspsgnsfhvfdqgqfakevlpkyfkhnnma
sfvrqlnmygfrkvvhieqgglvkperddtefqhpcflrgqeqllenikrkvt

    Sequence, based on observed residues (ATOM records): (download) 
    >7dcsB (B:)
hvpafltklwtlvsdpdtdalicwspsgnsfhvfdqgqfakevlpkyfkhnnmasfvrql
nmygfrkvvhieqgglvddtefqhpcflrgqeqllenikrkv

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >7dcsC (C:)
ghhhhhhvpafltklwtlvsdpdtdalicwspsgnsfhvfdqgqfakevlpkyfkhnnma
sfvrqlnmygfrkvvhieqgglvkperddtefqhpcflrgqeqllenikrkvt

    Sequence, based on observed residues (ATOM records): (download) 
    >7dcsC (C:)
hvpafltklwtlvsdpdtdalicwspsgnsfhvfdqgqfakevlpkyfkhnnmasfvrql
nmygfrkvvhdtefqhpcflrgqeqllenikrkv

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >7dcsD (D:)
ghhhhhhvpafltklwtlvsdpdtdalicwspsgnsfhvfdqgqfakevlpkyfkhnnma
sfvrqlnmygfrkvvhieqgglvkperddtefqhpcflrgqeqllenikrkvt

    Sequence, based on observed residues (ATOM records): (download) 
    >7dcsD (D:)
hvpafltklwtlvsdpdtdalicwspsgnsfhvfdqgqfakevlpkyfkhnnmasfvrql
nmygfrkvvhidtefqhpcflrgqeqllenikrkv

  • Chain 'E':
    Sequence, based on SEQRES records: (download) 
    >7dcsE (E:)
ghhhhhhvpafltklwtlvsdpdtdalicwspsgnsfhvfdqgqfakevlpkyfkhnnma
sfvrqlnmygfrkvvhieqgglvkperddtefqhpcflrgqeqllenikrkvt

    Sequence, based on observed residues (ATOM records): (download) 
    >7dcsE (E:)
vpafltklwtlvsdpdtdalicwspsgnsfhvfdqgqfakevlpkyfkhnnmasfvrqln
mygfrkvvhieqgglvkperddtefqhpcflrgqeqllenikrkv

  • Chain 'F':
    Sequence, based on SEQRES records: (download) 
    >7dcsF (F:)
ghhhhhhvpafltklwtlvsdpdtdalicwspsgnsfhvfdqgqfakevlpkyfkhnnma
sfvrqlnmygfrkvvhieqgglvkperddtefqhpcflrgqeqllenikrkvt

    Sequence, based on observed residues (ATOM records): (download) 
    >7dcsF (F:)
vpafltklwtlvsdpdtdalicwspsgnsfhvfdqgqfakevlpkyfkhnnmasfvrqln
mygfrkvvhdtefqhpcflrgqeqllenikrkv

  • Chain 'G':
    No sequence available.

  • Chain 'H':
    No sequence available.

  • Chain 'I':
    No sequence available.

  • Chain 'J':
    No sequence available.