PDB entry 7d9p

View 7d9p on RCSB PDB site
Description: Crystal Structure of Recombinant Human Acetylcholinesterase in Complex with Compound 12
Class: hydrolase
Keywords: AchE inhibitor, complex structure, HYDROLASE
Deposited on 2020-10-14, released 2021-08-25
The last revision prior to the SCOPe 2.08 freeze date was dated 2021-08-25, with a file datestamp of 2021-08-20.
Experiment type: XRAY
Resolution: 2.85 Å
R-factor: N/A
AEROSPACI score: 0.22 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: acetylcholinesterase
    Species: Homo sapiens [TaxId:9606]
    Gene: ACHE
    Database cross-references and differences (RAF-indexed):
    • Uniprot P22303 (10-552)
      • expression tag (0-9)
    Domains in SCOPe 2.08: d7d9pa_
  • Chain 'B':
    Compound: acetylcholinesterase
    Species: Homo sapiens [TaxId:9606]
    Gene: ACHE
    Database cross-references and differences (RAF-indexed):
    • Uniprot P22303 (10-552)
      • expression tag (0-9)
    Domains in SCOPe 2.08: d7d9pb_
  • Heterogens: H0R

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >7d9pA (A:)
gshhhhhhhhegredaellvtvrggrlrgirlktpggpvsaflgipfaeppmgprrflpp
epkqpwsgvvdattfqsvcyqyvdtlypgfegtemwnpnrelsedclylnvwtpyprpts
ptpvlvwiygggfysgassldvydgrflvqaertvlvsmnyrvgafgflalpgsreapgn
vglldqrlalqwvqenvaafggdptsvtlfgesagaasvgmhllsppsrglfhravlqsg
apngpwatvgmgearrratqlahlvgcppggtggndtelvaclrtrpaqvlvnhewhvlp
qesvfrfsfvpvvdgdflsdtpealinagdfhglqvlvgvvkdegsyflvygapgfskdn
eslisraeflagvrvgvpqvsdlaaeavvlhytdwlhpedparlrealsdvvgdhnvvcp
vaqlagrlaaqgarvyayvfehrastlswplwmgvphgyeiefifgipldpsrnytaeek
ifaqrlmrywanfartgdpneprdpkapqwppytagaqqyvsldlrplevrrglraqaca
fwnrflpkllsat

    Sequence, based on observed residues (ATOM records): (download) 
    >7d9pA (A:)
edaellvtvrggrlrgirlktpggpvsaflgipfaeppmgprrflppepkqpwsgvvdat
tfqsvcyqyvdtlypgfegtemwnpnrelsedclylnvwtpyprptsptpvlvwiygggf
ysgassldvydgrflvqaertvlvsmnyrvgafgflalpgsreapgnvglldqrlalqwv
qenvaafggdptsvtlfgesagaasvgmhllsppsrglfhravlqsgapngpwatvgmge
arrratqlahlvgcpndtelvaclrtrpaqvlvnhewhvlpqesvfrfsfvpvvdgdfls
dtpealinagdfhglqvlvgvvkdegsyflvygapgfskdneslisraeflagvrvgvpq
vsdlaaeavvlhytdwlhpedparlrealsdvvgdhnvvcpvaqlagrlaaqgarvyayv
fehrastlswplwmgvphgyeiefifgipldpsrnytaeekifaqrlmrywanfartgdp
neppqwppytagaqqyvsldlrplevrrglraqacafwnrflpkllsa

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >7d9pB (B:)
gshhhhhhhhegredaellvtvrggrlrgirlktpggpvsaflgipfaeppmgprrflpp
epkqpwsgvvdattfqsvcyqyvdtlypgfegtemwnpnrelsedclylnvwtpyprpts
ptpvlvwiygggfysgassldvydgrflvqaertvlvsmnyrvgafgflalpgsreapgn
vglldqrlalqwvqenvaafggdptsvtlfgesagaasvgmhllsppsrglfhravlqsg
apngpwatvgmgearrratqlahlvgcppggtggndtelvaclrtrpaqvlvnhewhvlp
qesvfrfsfvpvvdgdflsdtpealinagdfhglqvlvgvvkdegsyflvygapgfskdn
eslisraeflagvrvgvpqvsdlaaeavvlhytdwlhpedparlrealsdvvgdhnvvcp
vaqlagrlaaqgarvyayvfehrastlswplwmgvphgyeiefifgipldpsrnytaeek
ifaqrlmrywanfartgdpneprdpkapqwppytagaqqyvsldlrplevrrglraqaca
fwnrflpkllsat

    Sequence, based on observed residues (ATOM records): (download) 
    >7d9pB (B:)
edaellvtvrggrlrgirlktpggpvsaflgipfaeppmgprrflppepkqpwsgvvdat
tfqsvcyqyvdtlypgfegtemwnpnrelsedclylnvwtpyprptsptpvlvwiygggf
ysgassldvydgrflvqaertvlvsmnyrvgafgflalpgsreapgnvglldqrlalqwv
qenvaafggdptsvtlfgesagaasvgmhllsppsrglfhravlqsgapngpwatvgmge
arrratqlahlvgcpndtelvaclrtrpaqvlvnhewhvlpqesvfrfsfvpvvdgdfls
dtpealinagdfhglqvlvgvvkdegsyflvygapgfskdneslisraeflagvrvgvpq
vsdlaaeavvlhytdwlhpedparlrealsdvvgdhnvvcpvaqlagrlaaqgarvyayv
fehrastlswplwmgvphgyeiefifgipldpsrnytaeekifaqrlmrywanfartgdp
neppqwppytagaqqyvsldlrplevrrglraqacafwnrflpkll