PDB entry 7d46

View 7d46 on RCSB PDB site
Description: eif2b apo
Deposited on 2020-09-22, released 2020-12-09
The last revision was dated 2021-01-27, with a file datestamp of 2021-01-22.
Experiment type: EM
Resolution: 4 Å
R-factor: N/A
AEROSPACI score: 0.08 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Translation initiation factor eIF-2B subunit alpha
    Species: Homo sapiens [TaxId:9606]
    Gene: EIF2B1, EIF2BA
    Database cross-references and differences (RAF-indexed):
  • Chain 'B':
    Compound: Translation initiation factor eIF-2B subunit alpha
    Species: Homo sapiens [TaxId:9606]
    Gene: EIF2B1, EIF2BA
    Database cross-references and differences (RAF-indexed):
  • Chain 'C':
    Compound: Translation initiation factor eIF-2B subunit beta
    Species: Homo sapiens [TaxId:9606]
    Gene: EIF2B2, EIF2BB
    Database cross-references and differences (RAF-indexed):
  • Chain 'D':
    Compound: Translation initiation factor eIF-2B subunit beta
    Species: Homo sapiens [TaxId:9606]
    Gene: EIF2B2, EIF2BB
    Database cross-references and differences (RAF-indexed):
  • Chain 'E':
    Compound: Translation initiation factor eIF-2B subunit gamma
    Species: Homo sapiens [TaxId:9606]
    Gene: EIF2B3
    Database cross-references and differences (RAF-indexed):
  • Chain 'F':
    Compound: Translation initiation factor eIF-2B subunit gamma
    Species: Homo sapiens [TaxId:9606]
    Gene: EIF2B3
    Database cross-references and differences (RAF-indexed):
  • Chain 'G':
    Compound: Translation initiation factor eIF-2B subunit delta
    Species: Homo sapiens [TaxId:9606]
    Gene: EIF2B4, EIF2BD
    Database cross-references and differences (RAF-indexed):
  • Chain 'H':
    Compound: Translation initiation factor eIF-2B subunit delta
    Species: Homo sapiens [TaxId:9606]
    Gene: EIF2B4, EIF2BD
    Database cross-references and differences (RAF-indexed):
  • Chain 'I':
    Compound: Translation initiation factor eIF-2B subunit epsilon
    Species: Homo sapiens [TaxId:9606]
    Gene: EIF2B5, EIF2BE
    Database cross-references and differences (RAF-indexed):
  • Chain 'J':
    Compound: Translation initiation factor eIF-2B subunit epsilon
    Species: Homo sapiens [TaxId:9606]
    Gene: EIF2B5, EIF2BE
    Database cross-references and differences (RAF-indexed):

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >7d46A (A:)
mddkelieyfksqmkedpdmasavaairtlleflkrdkgetiqglranltsaietlcgvd
ssvavssggelflrfislasleysdyskckkimiergelflrrislsrnkiadlchtfik
dgatilthaysrvvlrvleaavaakkrfsvyvtesqpdlsgkkmakalchlnvpvtvvld
aavgyimekadlvivgaegvvenggiinkigtnqmavcakaqnkpfyvvaesfkfvrlfp
lnqqdvpdkfkykadtlkvaqtgqdlkeehpwvdytapslitllftdlgvltpsavsdel
iklyl

    Sequence, based on observed residues (ATOM records):
    >7d46A (A:)
mddkelieyfksqmkedpdmasavaairtlleflkrdkgetiqglranltsaietlcgvd
ssvavssggelflrfislasleysdyskckkimiergelflrrislsrnkiadlchtfik
dgatilthaysrvvlrvleaavaakkrfsvyvtesqpdlsgkkmakalchlnvpvtvvld
aavgyimekadlvivgaegvvenggiinkigtnqmavcakaqnkpfyvvaesfkfvrlfp
lnqqdvpdkfkykadeehpwvdytapslitllftdlgvltpsavsdeliklyl

  • Chain 'B':
    Sequence, based on SEQRES records:
    >7d46B (B:)
mddkelieyfksqmkedpdmasavaairtlleflkrdkgetiqglranltsaietlcgvd
ssvavssggelflrfislasleysdyskckkimiergelflrrislsrnkiadlchtfik
dgatilthaysrvvlrvleaavaakkrfsvyvtesqpdlsgkkmakalchlnvpvtvvld
aavgyimekadlvivgaegvvenggiinkigtnqmavcakaqnkpfyvvaesfkfvrlfp
lnqqdvpdkfkykadtlkvaqtgqdlkeehpwvdytapslitllftdlgvltpsavsdel
iklyl

    Sequence, based on observed residues (ATOM records):
    >7d46B (B:)
mddkelieyfksqmkedpdmasavaairtlleflkrdkgetiqglranltsaietlcgvd
ssvavssggelflrfislasleysdyskckkimiergelflrrislsrnkiadlchtfik
dgatilthaysrvvlrvleaavaakkrfsvyvtesqpdlsgkkmakalchlnvpvtvvld
aavgyimekadlvivgaegvvenggiinkigtnqmavcakaqnkpfyvvaesfkfvrlfp
lnqqdvpdkfkykeehpwvdytapslitllftdlgvltpsavsdeliklyl

  • Chain 'C':
    Sequence, based on SEQRES records:
    >7d46C (C:)
mpgsaakgselseriesfvetlkrgggprsseemaretlgllrqiitdhrwsnagelmel
irregrrmtaaqpsettvgnmvrrvlkiireeygrlhgrsdesdqqeslhklltsgglne
dfsfhyaqlqsniieainellvelegtmeniaaqalehihsnevimtigfsrtveaflke
aarkrkfhvivaecapfcqghemavnlskagiettvmtdaaifavmsrvnkviigtktil
angalravtgthtlalaakhhstplivcapmfklspqfpneedsfhkfvapeevlpfteg
dilekvsvhcpvfdyvppelitlfisniggnapsyiyrlmselyhpddhvl

    Sequence, based on observed residues (ATOM records):
    >7d46C (C:)
gselseriesfvetlkrgggprsseemaretlgllrqiitdhrwsnagelmelirregrr
mtaaqpsettvgnmvrrvlkiireeygrlhgfsfhyaqlqsniieainellvelegtmen
iaaqalehihsnevimtigfsrtveaflkeaarkrkfhvivaecapfcqghemavnlska
giettvmtdaaifavmsrvnkviigtktilangalravtgthtlalaakhhstplivcap
mfklspqfpneedsfhkfvapeevlpftegdilekvsvhcpvfdyvppelitlfisnigg
napsyiyrlmselyhpddhvl

  • Chain 'D':
    Sequence, based on SEQRES records:
    >7d46D (D:)
mpgsaakgselseriesfvetlkrgggprsseemaretlgllrqiitdhrwsnagelmel
irregrrmtaaqpsettvgnmvrrvlkiireeygrlhgrsdesdqqeslhklltsgglne
dfsfhyaqlqsniieainellvelegtmeniaaqalehihsnevimtigfsrtveaflke
aarkrkfhvivaecapfcqghemavnlskagiettvmtdaaifavmsrvnkviigtktil
angalravtgthtlalaakhhstplivcapmfklspqfpneedsfhkfvapeevlpfteg
dilekvsvhcpvfdyvppelitlfisniggnapsyiyrlmselyhpddhvl

    Sequence, based on observed residues (ATOM records):
    >7d46D (D:)
gselseriesfvetlkrgggprsseemaretlgllrqiitdhrwsnagelmelirregrr
mtaaqpsettvgnmvrrvlkiireeygrlhgnedfsfhyaqlqsniieainellvelegt
meniaaqalehihsnevimtigfsrtveaflkeaarkrkfhvivaecapfcqghemavnl
skagiettvmtdaaifavmsrvnkviigtktilangalravtgthtlalaakhhstpliv
capmfklspqfpneedsfhkfvapeevlpftegdilekvsvhcpvfdyvppelitlfisn
iggnapsyiyrlmselyhpddhvl

  • Chain 'E':
    Sequence, based on SEQRES records:
    >7d46E (E:)
mefqavvmavgggsrmtdltssipkpllpvgnkpliwyplnllervgfeevivvttrdvq
kalcaefkmkmkpdivcipddadmgtadslryiypklktdvlvlscdlitdvalhevvdl
fraydaslamlmrkgqdsiepvpgqkgkkkaveqrdfigvdstgkrllfmaneadldeel
vikgsilqkhprirfhtglvdahlyclkkyivdflmengsitsirselipylvrkqfssa
ssqqgqeekeedlkkkelksldiysfikeantlnlapydacwnacrgdrwedlsrsqvrc
yvhimkeglcsrvstlglymeanrqvpkllsalcpeeppvhssaqivskhlvgvdsligp
etqigekssikrsvigssclikdrvtitncllmnsvtveegsniqgsvicnnaviekgad
ikdcligsgqrieakakrvnevivgndqlmei

    Sequence, based on observed residues (ATOM records):
    >7d46E (E:)
mefqavvmavgpllpvgnkpliwyplnllervgfeevivvttrdvqkalcaefkmkmkpd
ivcipddadmgtadslryiypklktdvlvlscdlitdvalhevvdlfraydaslamlmrk
rdfigvdstgkrllfmaneadldeelvikgsilqkhprirfhtglvdahlyclkkyivdf
lmengsitsirselipylvrkqfslksldiysfikeantlnlapydacwnacrgdrwedl
srssaqivskhlvgvdsligpetqigekssikrsvigssclikdrvtitncllmnsvtve
egsniqgsvicnnaviekgadikdcligsgqrieakakrvneviv

  • Chain 'F':
    Sequence, based on SEQRES records:
    >7d46F (F:)
mefqavvmavgggsrmtdltssipkpllpvgnkpliwyplnllervgfeevivvttrdvq
kalcaefkmkmkpdivcipddadmgtadslryiypklktdvlvlscdlitdvalhevvdl
fraydaslamlmrkgqdsiepvpgqkgkkkaveqrdfigvdstgkrllfmaneadldeel
vikgsilqkhprirfhtglvdahlyclkkyivdflmengsitsirselipylvrkqfssa
ssqqgqeekeedlkkkelksldiysfikeantlnlapydacwnacrgdrwedlsrsqvrc
yvhimkeglcsrvstlglymeanrqvpkllsalcpeeppvhssaqivskhlvgvdsligp
etqigekssikrsvigssclikdrvtitncllmnsvtveegsniqgsvicnnaviekgad
ikdcligsgqrieakakrvnevivgndqlmei

    Sequence, based on observed residues (ATOM records):
    >7d46F (F:)
mefqavvmavgpllpvgnkpliwyplnllervgfeevivvttrdvqkalcaefkmkmkpd
ivcipddadmgtadslryiypklktdvlvlscdlitdvalhevvdlfraydaslamlmrk
rdfigvdstgkrllfmaneadldeelvikgsilqkhprirfhtglvdahlyclkkyivdf
lmengsitsirselipylvrkqfslksldiysfikeantlnlapydacwnacrgdrwedl
srssaqivskhlvgvdsligpetqigekssikrsvigssclikdrvtitncllmnsvtve
egsniqgsvicnnaviekgadikdcligsgqrieakakrvneviv

  • Chain 'G':
    Sequence, based on SEQRES records:
    >7d46G (G:)
maavavavredsgsgmkaelppgpgavgremtkeeklqlrkekkqqkkkrkeekgaepet
gsavsaaqcqvgptrelpesgiqlgtprekvpagrskaelraerrakqeaeralkqarkg
eqggpppkaspstagetpsgvkrlpeypqvddlllrrlvkkperqqvptrkdygskvslf
shlpqysrqnsltqfmsipssvihpamvrlglqysqglvsgsnarciallralqqviqdy
ttppneelsrdlvnklkpymsfltqcrplsasmhnaikflnkeitsvgsskreeeaksel
raaidryvqekivlaaqaisrfayqkisngdvilvygcsslvsrilqeawtegrrfrvvv
vdsrpwlegrhtlrslvhagvpasyllipaasyvlpevskvllgahallangsvmsrvgt
aqlalvarahnvpvlvccetykfcervqtdafvsnelddpddlqckrgehvalanwqnha
slrllnlvydvtppelvdlvitelgmipcssvpvvlrvkssdq

    Sequence, based on observed residues (ATOM records):
    >7d46G (G:)
qvptrkdygskvslfshlpqysrqnsltqfmsipssvihpamvrlglqysqglvsgsnar
ciallralqqviqdyttppneelsrdlvnklkpymsfltqcrplsasmhnaikflnkeit
svgsskreeeakselraaidryvqekivlaaqaisrfayqkisngdvilvygcsslvsri
lqeawtegrrfrvvvvdsrpwlegrhtlrslvhagvpasyllipaasyvlpevskvllga
hallangsvmsrvgtaqlalvarahnvpvlvccetykfcervqtdafvsnelddpddlqc
krgehvalanwqnhaslrllnlvydvtppelvdlvitelgmipcssvpvvlrv

  • Chain 'H':
    Sequence, based on SEQRES records:
    >7d46H (H:)
maavavavredsgsgmkaelppgpgavgremtkeeklqlrkekkqqkkkrkeekgaepet
gsavsaaqcqvgptrelpesgiqlgtprekvpagrskaelraerrakqeaeralkqarkg
eqggpppkaspstagetpsgvkrlpeypqvddlllrrlvkkperqqvptrkdygskvslf
shlpqysrqnsltqfmsipssvihpamvrlglqysqglvsgsnarciallralqqviqdy
ttppneelsrdlvnklkpymsfltqcrplsasmhnaikflnkeitsvgsskreeeaksel
raaidryvqekivlaaqaisrfayqkisngdvilvygcsslvsrilqeawtegrrfrvvv
vdsrpwlegrhtlrslvhagvpasyllipaasyvlpevskvllgahallangsvmsrvgt
aqlalvarahnvpvlvccetykfcervqtdafvsnelddpddlqckrgehvalanwqnha
slrllnlvydvtppelvdlvitelgmipcssvpvvlrvkssdq

    Sequence, based on observed residues (ATOM records):
    >7d46H (H:)
qvptrkdygskvslfshlpqysrqnsltqfmsipssvihpamvrlglqysqglvsgsnar
ciallralqqviqdyttppneelsrdlvnklkpymsfltqcrplsasmhnaikflnkeit
svgsskreeeakselraaidryvqekivlaaqaisrfayqkisngdvilvygcsslvsri
lqeawtegrrfrvvvvdsrpwlegrhtlrslvhagvpasyllipaasyvlpevskvllga
hallangsvmsrvgtaqlalvarahnvpvlvccetykfcervqtdafvsnelddpddlqc
krgehvalanwqnhaslrllnlvydvtppelvdlvitelgmipcssvpvvlrv

  • Chain 'I':
    Sequence, based on SEQRES records:
    >7d46I (I:)
maapvvappgvvvsrankrsgagpggsggggargaeeepppplqavlvadsfdrrffpis
kdqprvllplanvalidytlefltatgvqetfvfccwkaaqikehllkskwcrptslnvv
riitselyrslgdvlrdvdakalvrsdfllvygdvisninitraleehrlrrkleknvsv
mtmifkesspshptrchednvvvavdsttnrvlhfqktqglrrfafplslfqgssdgvev
rydlldchisicspqvaqlftdnfdyqtrddfvrgllvneeilgnqihmhvtakeygarv
snlhmysavcadvirrwvypltpeanftdsttqscthsrhniyrgpevslghgsileenv
llgsgtvigsncfitnsvigpgchigdnvvldqtylwqgvrvaagaqihqsllcdnaevk
ervtlkprsvltsqvvvgpnitlpegsvislhppdaeededdgefsddsgadqekdkvkm
kgynpaevgaagkgylwkaagmnmeeeeelqqnlwglkinmeeeseseseqsmdseepds
rggspqmddikvfqnevlgtlqrgkeeniscdnlvleinslkyaynislkevmqvlshvv
lefplqqmdspldssrycalllpllkawspvfrnyikraadhlealaaiedfflehealg
ismakvlmafyqleilaeetilswfsqrdttdkgqqlrknqqlqrfiqwlkeaeeessed
d

    Sequence, based on observed residues (ATOM records):
    >7d46I (I:)
pplqavlvadsfdrrffpiskdqprvllplanvalidytlefltatgvqetfvfccwkaa
qikehllkskwcrptslnvvriitselyrslgdvlrdvdakalvrsdfllvygdvisnin
itraleehrlrrkleknvsvmtmifkesspshptrchednvvvavdsttnrvlhfqktqg
lrrfafplslfqgssdgvevrydlldchisicspqvaqlftdnfdyqtrddfvrgllvne
eilgnqihmhvtakeygarvsnlhmysavcadvirrwvypltpeanftdsttqscthsrh
niyrgpevslghgsileenvllgsgtvigsncfitnsvigpgchigdnvvldqtylwqgv
rvaagaqihqsllcdnaevkervtlkprsvltsqvvvgpnitlpegsvislhppdaeede
ddgefsd

  • Chain 'J':
    Sequence, based on SEQRES records:
    >7d46J (J:)
maapvvappgvvvsrankrsgagpggsggggargaeeepppplqavlvadsfdrrffpis
kdqprvllplanvalidytlefltatgvqetfvfccwkaaqikehllkskwcrptslnvv
riitselyrslgdvlrdvdakalvrsdfllvygdvisninitraleehrlrrkleknvsv
mtmifkesspshptrchednvvvavdsttnrvlhfqktqglrrfafplslfqgssdgvev
rydlldchisicspqvaqlftdnfdyqtrddfvrgllvneeilgnqihmhvtakeygarv
snlhmysavcadvirrwvypltpeanftdsttqscthsrhniyrgpevslghgsileenv
llgsgtvigsncfitnsvigpgchigdnvvldqtylwqgvrvaagaqihqsllcdnaevk
ervtlkprsvltsqvvvgpnitlpegsvislhppdaeededdgefsddsgadqekdkvkm
kgynpaevgaagkgylwkaagmnmeeeeelqqnlwglkinmeeeseseseqsmdseepds
rggspqmddikvfqnevlgtlqrgkeeniscdnlvleinslkyaynislkevmqvlshvv
lefplqqmdspldssrycalllpllkawspvfrnyikraadhlealaaiedfflehealg
ismakvlmafyqleilaeetilswfsqrdttdkgqqlrknqqlqrfiqwlkeaeeessed
d

    Sequence, based on observed residues (ATOM records):
    >7d46J (J:)
ppplqavlvadsfdrrffpiskdqprvllplanvalidytlefltatgvqetfvfccwka
aqikehllkskwcrptslnvvriitselyrslgdvlrdvdakalvrsdfllvygdvisni
nitraleehrlrrkleknvsvmtmifkesspshptrchednvvvavdsttnrvlhfqktq
glrrfafplslfqgssdgvevrydlldchisicspqvaqlftdnfdyqtrddfvrgllvn
eeilgnqihmhvtakeygarvsnlhmysavcadvirrwvypltpeanftdsttqscthsr
hniyrgpevslghgsileenvllgsgtvigsncfitnsvigpgchigdnvvldqtylwqg
vrvaagaqihqsllcdnaevkervtlkprsvltsqvvvgpnitlpegsvislhppdaeed
eddgefsdd