PDB entry 7cyq

View 7cyq on RCSB PDB site
Description: cryo-em structure of an extended sars-cov-2 replication and transcription complex reveals an intermediate state in cap synthesis
Deposited on 2020-09-04, released 2020-12-09
The last revision was dated 2021-03-10, with a file datestamp of 2021-03-05.
Experiment type: EM
Resolution: 2.83 Å
R-factor: N/A
AEROSPACI score: 0.17 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: RNA-directed RNA polymerase
    Species: Severe acute respiratory syndrome coronavirus 2 [TaxId:2697049]
    Gene: rep, 1a-1b
    Database cross-references and differences (RAF-indexed):
  • Chain 'B':
    Compound: Non-structural protein 8
    Species: Severe acute respiratory syndrome coronavirus 2 [TaxId:2697049]
    Gene: rep, 1a-1b
    Database cross-references and differences (RAF-indexed):
  • Chain 'C':
    Compound: Non-structural protein 7
    Species: Severe acute respiratory syndrome coronavirus 2 [TaxId:2697049]
    Gene: rep, 1a-1b
    Database cross-references and differences (RAF-indexed):
  • Chain 'D':
    Compound: Non-structural protein 8
    Species: Severe acute respiratory syndrome coronavirus 2 [TaxId:2697049]
    Gene: rep, 1a-1b
    Database cross-references and differences (RAF-indexed):
  • Chain 'E':
    Compound: Helicase
    Species: Severe acute respiratory syndrome coronavirus 2 [TaxId:2697049]
    Gene: rep, 1a-1b
    Database cross-references and differences (RAF-indexed):
  • Chain 'F':
    Compound: Helicase
    Species: Severe acute respiratory syndrome coronavirus 2 [TaxId:2697049]
    Gene: rep, 1a-1b
    Database cross-references and differences (RAF-indexed):
  • Chain 'G':
    Compound: Non-structural protein 9
    Species: Severe acute respiratory syndrome coronavirus 2 [TaxId:2697049]
    Gene: rep, 1a-1b
    Database cross-references and differences (RAF-indexed):
  • Chain 'I':
    Compound: Primer
    Species: Severe acute respiratory syndrome coronavirus 2, synthetic [TaxId:2697049]
  • Chain 'J':
    Compound: Template
    Species: Severe acute respiratory syndrome coronavirus 2, synthetic [TaxId:2697049]
  • Heterogens: GDP, MG, ZN

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >7cyqA (A:)
sadaqsflnrvcgvsaarltpcgtgtstdvvyrafdiyndkvagfakflktnccrfqekd
eddnlidsyfvvkrhtfsnyqheetiynllkdcpavakhdffkfridgdmvphisrqrlt
kytmadlvyalrhfdegncdtlkeilvtynccdddyfnkkdwydfvenpdilrvyanlge
rvrqallktvqfcdamrnagivgvltldnqdlngnwydfgdfiqttpgsgvpvvdsyysl
lmpiltltraltaeshvdtdltkpyikwdllkydfteerlklfdryfkywdqtyhpncvn
clddrcilhcanfnvlfstvfpptsfgplvrkifvdgvpfvvstgyhfrelgvvhnqdvn
lhssrlsfkellvyaadpamhaasgnllldkrttcfsvaaltnnvafqtvkpgnfnkdfy
dfavskgffkegssvelkhfffaqdgnaaisdydyyrynlptmcdirqllfvvevvdkyf
dcydggcinanqvivnnldksagfpfnkwgkarlyydsmsyedqdalfaytkrnviptit
qmnlkyaisaknrartvagvsicstmtnrqfhqkllksiaatrgatvvigtskfyggwhn
mlktvysdvenphlmgwdypkcdrampnmlrimaslvlarkhttccslshrfyrlaneca
qvlsemvmcggslyvkpggtssgdattayansvfnicqavtanvnallstdgnkiadkyv
rnlqhrlyeclyrnrdvdtdfvnefyaylrkhfsmmilsddavvcfnstyasqglvasik
nfksvlyyqnnvfmseakcwtetdltkgphefcsqhtmlvkqgddyvylpypdpsrilga
gcfvddivktdgtlmierfvslaidaypltkhpnqeyadvfhlylqyirklhdeltghml
dmysvmltndntsrywepefyeamytphtvlqhhhhhhhhhh

    Sequence, based on observed residues (ATOM records):
    >7cyqA (A:)
aqsflnrvcgvsaarltpcgtgtstdvvyrafdiyndkvagfakflktnccrfqekdedd
nlidsyfvvkrhtfsnyqheetiynllkdcpavakhdffkfridgdmvphisrqrltkyt
madlvyalrhfdegncdtlkeilvtynccdddyfnkkdwydfvenpdilrvyanlgervr
qallktvqfcdamrnagivgvltldnqdlngnwydfgdfiqttpgsgvpvvdsyysllmp
iltltraltaeshvdtdltkpyikwdllkydfteerlklfdryfkywdqtyhpncvncld
drcilhcanfnvlfstvfpptsfgplvrkifvdgvpfvvstgyhfrelgvvhnqdvnlhs
srlsfkellvyaadpamhaasgnllldkrttcfsvaaltnnvafqtvkpgnfnkdfydfa
vskgffkegssvelkhfffaqdgnaaisdydyyrynlptmcdirqllfvvevvdkyfdcy
dggcinanqvivnnldksagfpfnkwgkarlyydsmsyedqdalfaytkrnviptitqmn
lkyaisaknrartvagvsicstmtnrqfhqkllksiaatrgatvvigtskfyggwhnmlk
tvysdvenphlmgwdypkcdrampnmlrimaslvlarkhttccslshrfyrlanecaqvl
semvmcggslyvkpggtssgdattayansvfnicqavtanvnallstdgnkiadkyvrnl
qhrlyeclyrnrdvdtdfvnefyaylrkhfsmmilsddavvcfnstyasqglvasiknfk
svlyyqnnvfmseakcwtetdltkgphefcsqhtmlvkqgddyvylpypdpsrilgagcf
vddivktdgtlmierfvslaidaypltkhpnqeyadvfhlylqyirklhdeltghmldmy
svmltndntsrywepefyeamytpht

  • Chain 'B':
    Sequence, based on SEQRES records:
    >7cyqB (B:)
aiasefsslpsyaafataqeayeqavangdsevvlkklkkslnvaksefdrdaamqrkle
kmadqamtqmykqarsedkrakvtsamqtmlftmlrkldndalnniinnardgcvplnii
plttaaklmvvipdyntykntcdgttftyasalweiqqvvdadskivqlseismdnspnl
awplivtalransavklq

    Sequence, based on observed residues (ATOM records):
    >7cyqB (B:)
fsslpsyaafataqeayeqavangdsevvlkklkkslnvaksefdrdaamqrklekmadq
amtqmykqarsedkrakvtsamqtmlftmlrkldndalnniinnardgcvplniipltta
aklmvvipdyntykntcdgttftyasalweiqqvvdadskivqlseismdnspnlawpli
vtalran

  • Chain 'C':
    Sequence, based on SEQRES records:
    >7cyqC (C:)
skmsdvkctsvvllsvlqqlrvesssklwaqcvqlhndillakdtteafekmvsllsvll
smqgavdinklceemldnratlq

    Sequence, based on observed residues (ATOM records):
    >7cyqC (C:)
kmsdvkctsvvllsvlqqlrvesssklwaqcvqlhndillakdtteafekmvsllsvlls
mqgavdinklce

  • Chain 'D':
    Sequence, based on SEQRES records:
    >7cyqD (D:)
aiasefsslpsyaafataqeayeqavangdsevvlkklkkslnvaksefdrdaamqrkle
kmadqamtqmykqarsedkrakvtsamqtmlftmlrkldndalnniinnardgcvplnii
plttaaklmvvipdyntykntcdgttftyasalweiqqvvdadskivqlseismdnspnl
awplivtalransavklq

    Sequence, based on observed residues (ATOM records):
    >7cyqD (D:)
fsslpsyaafataqeayeqavangdsevvlkklkkslnvaksefdrdaamqrklekmadq
amtqmykqarsedkrakvtsamqtmlftmlrkldndalnniinnardgcvplniipltta
aklmvvipdyntykntcdgttftyasalweiqqvvdadskivqlseismdnspnlawpli
vtalra

  • Chain 'E':
    Sequence, based on SEQRES records:
    >7cyqE (E:)
avgacvlcnsqtslrcgacirrpflcckccydhvistshklvlsvnpyvcnapgcdvtdv
tqlylggmsyyckshkppisfplcangqvfglykntcvgsdnvtdfnaiatcdwtnagdy
ilantcterlklfaaetlkateetfklsygiatvrevlsdrelhlswevgkprpplnrny
vftgyrvtknskvqigeytfekgdygdavvyrgtttyklnvgdyfvltshtvmplsaptl
vpqehyvritglyptlnisdefssnvanyqkvgmqkystlqgppgtgkshfaiglalyyp
sarivytacshaavdalcekalkylpidkcsriipararvecfdkfkvnstleqyvfctv
nalpettadivvfdeismatnydlsvvnarlrakhyvyigdpaqlpaprtlltkgtlepe
yfnsvcrlmktigpdmflgtcrrcpaeivdtvsalvydnklkahkdksaqcfkmfykgvi
thdvssainrpqigvvrefltrnpawrkavfispynsqnavaskilglptqtvdssqgse
ydyviftqttetahscnvnrfnvaitrakvgilcimsdrdlydklqftsleiprrnvatl
q

    Sequence, based on observed residues (ATOM records):
    >7cyqE (E:)
avgacvlcnsqtslrcgacirrpflcckccydhvistshklvlsvnpyvcnapgcdvtdv
tqlylggmsyyckshkppisfplcangqvfglykntcvgsdnvtdfnaiatcdwtnagdy
ilantcterlklfaaetlkateetfklsygiatvrevlsdrelhlswevgkprpplnrny
vftgyrvtknskvqigeytfekgavvyrgtttyklnvgdyfvltshtvmplsaptlvpqe
hyvritglyptlnisdefssnvanyqkvgmqkystlqgppgtgkshfaiglalyypsari
vytacshaavdalcekalkylpidkcsriipavecfdkfkvnstleqyvfctvnalpett
adivvfdeismatnydlsvvnarlrakhyvyigdpaqlpaprtlltkgtlepeyfnsvcr
lmktigpdmflgtcrrcpaeivdtvsalvydnklkahkdksaqcfkmfykgvithdvssa
inrpqigvvrefltrnpawrkavfispynsqnavaskilglptqtvdssqgseydyvift
qttetahscnvnrfnvaitrakvgilcimsdrdlydklqftsleip

  • Chain 'F':
    Sequence, based on SEQRES records:
    >7cyqF (F:)
avgacvlcnsqtslrcgacirrpflcckccydhvistshklvlsvnpyvcnapgcdvtdv
tqlylggmsyyckshkppisfplcangqvfglykntcvgsdnvtdfnaiatcdwtnagdy
ilantcterlklfaaetlkateetfklsygiatvrevlsdrelhlswevgkprpplnrny
vftgyrvtknskvqigeytfekgdygdavvyrgtttyklnvgdyfvltshtvmplsaptl
vpqehyvritglyptlnisdefssnvanyqkvgmqkystlqgppgtgkshfaiglalyyp
sarivytacshaavdalcekalkylpidkcsriipararvecfdkfkvnstleqyvfctv
nalpettadivvfdeismatnydlsvvnarlrakhyvyigdpaqlpaprtlltkgtlepe
yfnsvcrlmktigpdmflgtcrrcpaeivdtvsalvydnklkahkdksaqcfkmfykgvi
thdvssainrpqigvvrefltrnpawrkavfispynsqnavaskilglptqtvdssqgse
ydyviftqttetahscnvnrfnvaitrakvgilcimsdrdlydklqftsleiprrnvatl
q

    Sequence, based on observed residues (ATOM records):
    >7cyqF (F:)
vgacvlcnsqtslrcgacirrpflcckccydhvistshklvlsvnpyvcnapgcdvtdvt
qlylggmsyyckshkppisfplcangqvfglykntcvgsdnvtdfnaiatcdwtnagdyi
lantcterlklfaaetlkateetfklsygiatvrevlsdrelhlswevgkprpplnrnyv
ftgyrvtknskvqigeytfekgavvyrgtttyklnvgdyfvltshtvmplsaptlvpqeh
yvritglyptlnisdefssnvanyqkvgmqkystlqgppgtgkshfaiglalyypsariv
ytacshaavdalcekalkylpidkcsriipavecfdkfkvnstleqyvfctvnalpetta
divvfdeismatnydlsvvnarlrakhyvyigdpaqlpaprtlltkgtlepeyfnsvcrl
mktigpdmflgtcrrcpaeivdtvsalvydnklkahkdksaqcfkmfykgvithdvssai
nrpqigvvrefltrnpawrkavfispynsqnavaskilglptqtvdssqgseydyviftq
ttetahscnvnrfnvaitrakvgilcimsdrdlydklqftsleip

  • Chain 'G':
    Sequence, based on SEQRES records:
    >7cyqG (G:)
snamnnelspvalrqmscaagttqtactddnalayynttkggrfvlallsdlqdlkwarf
pksdgtgtiyteleppcrfvtdtpkgpkvkylyfikglnnlnrgmvlgslaatvrlq

    Sequence, based on observed residues (ATOM records):
    >7cyqG (G:)
nnelspvalrqmscaagttqtactddnalayynttkggrfvlallsdlqdlkwarfpksd
gtgtiyteleppcrfvtdtpkgpkvkylyfikglnnlnrgmvlgslaatvrlq

  • Chain 'I':
    No sequence available.

  • Chain 'J':
    No sequence available.