PDB entry 7cyn

View 7cyn on RCSB PDB site
Description: cryo-em structure of human tlr7 in complex with unc93b1
Deposited on 2020-09-03, released 2021-01-06
The last revision was dated 2021-02-24, with a file datestamp of 2021-02-19.
Experiment type: EM
Resolution: 4.2 Å
R-factor: N/A
AEROSPACI score: 0.08 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Toll-like receptor 7
    Species: Homo sapiens [TaxId:9606]
    Gene: TLR7, UNQ248/PRO285
    Database cross-references and differences (RAF-indexed):
  • Chain 'B':
    Compound: Toll-like receptor 7
    Species: Homo sapiens [TaxId:9606]
    Gene: TLR7, UNQ248/PRO285
    Database cross-references and differences (RAF-indexed):
  • Chain 'C':
    Compound: Protein unc-93 homolog B1
    Species: Homo sapiens [TaxId:9606]
    Gene: UNC93B1, UNC93, UNC93B
    Database cross-references and differences (RAF-indexed):
  • Chain 'D':
    Compound: Protein unc-93 homolog B1
    Species: Homo sapiens [TaxId:9606]
    Gene: UNC93B1, UNC93, UNC93B
    Database cross-references and differences (RAF-indexed):
  • Heterogens: NAG

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >7cynA (A:)
mvfpmwtlkrqililfniiliskllgarwfpktlpcdvtldvpknhvivdctdkhlteip
ggiptnttnltltinhipdispasfhrldhlveidfrcncvpiplgsknnmcikrlqikp
rsfsgltylkslyldgnqlleipqglppslqllsleannifsirkenltelanieilylg
qncyyrnpcyvsysiekdaflnltklkvlslkdnnvtavptvlpstltelylynnmiaki
qeddfnnlnqlqildlsgncprcynapfpcapcknnsplqipvnafdaltelkvlrlhsn
slqhvpprwfkninklqeldlsqnflakeigdakflhflpsliqldlsfnfelqvyrasm
nlsqafsslkslkilrirgyvfkelksfnlsplhnlqnlevldlgtnfikianlsmfkqf
krlkvidlsvnkispsgdssevgfcsnartsvesyepqvleqlhyfrydkyarscrfknk
easfmsvnescykygqtldlsknsiffvkssdfqhlsflkclnlsgnlisqtlngsefqp
laelryldfsnnrldllhstafeelhklevldissnshyfqsegithmlnftknlkvlqk
lmmndndissstsrtmeseslrtlefrgnhldvlwregdnrylqlfknllkleeldiskn
slsflpsgvfdgmppnlknlslaknglksfswkklqclknletldlshnqlttvperlsn
csrslknlilknnqirsltkyflqdafqlryldlssnkiqmiqktsfpenvlnnlkmlll
hhnrflctcdavwfvwwvnhtevtipylatdvtcvgpgahkgqsvisldlytceldltnl
ilfslsisvslflmvmmtashlyfwdvwyiyhfckakikgyqrlispdccydafivydtk
dpavtewvlaelvakledprekhfnlcleerdwlpgqpvlenlsqsiqlskktvfvmtdk
yaktenfkiafylshqrlmdekvdviiliflekpfqkskflqlrkrlcgssvlewptnpq
ahpyfwqclknalatdnhvaysqvfketv

    Sequence, based on observed residues (ATOM records):
    >7cynA (A:)
pktlpcdvtldvpknhvivdctdkhlteipggiptnttnltltinhipdispasfhrldh
lveidfrcncvpiplgsknnmcikrlqikprsfsgltylkslyldgnqlleipqglppsl
qllsleannifsirkenltelanieilylgqncyyrnpcyvsysiekdaflnltklkvls
lkdnnvtavptvlpstltelylynnmiakiqeddfnnlnqlqildlsgncprcynapfpc
apcknnsplqipvnafdaltelkvlrlhsnslqhvpprwfkninklqeldlsqnflakei
gdakflhflpsliqldlsfnfelqvyrasmnlsqafsslkslkilrirgyvfkelksfnl
splhnlqnlevldlgtnfikianlsmfkqfkrlkvidlsvnkispkyarscscykygqtl
dlsknsiffvkssdfqhlsflkclnlsgnlisqtlngsefqplaelryldfsnnrldllh
stafeelhklevldissnshyfqsegithmlnftknlkvlqklmmndndissstsrtmes
eslrtlefrgnhldvlwregdnrylqlfknllkleeldisknslsflpsgvfdgmppnlk
nlslaknglksfswkklqclknletldlshnqlttvperlsncsrslknlilknnqirsl
tkyflqdafqlryldlssnkiqmiqktsfpenvlnnlkmlllhhnrflctcdavwfvwwv
nhtevtipylatdvtcvgpgahkgqsvisldlytceldltnlilfslsisvslflmvmmt
ashlyf

  • Chain 'B':
    Sequence, based on SEQRES records:
    >7cynB (B:)
mvfpmwtlkrqililfniiliskllgarwfpktlpcdvtldvpknhvivdctdkhlteip
ggiptnttnltltinhipdispasfhrldhlveidfrcncvpiplgsknnmcikrlqikp
rsfsgltylkslyldgnqlleipqglppslqllsleannifsirkenltelanieilylg
qncyyrnpcyvsysiekdaflnltklkvlslkdnnvtavptvlpstltelylynnmiaki
qeddfnnlnqlqildlsgncprcynapfpcapcknnsplqipvnafdaltelkvlrlhsn
slqhvpprwfkninklqeldlsqnflakeigdakflhflpsliqldlsfnfelqvyrasm
nlsqafsslkslkilrirgyvfkelksfnlsplhnlqnlevldlgtnfikianlsmfkqf
krlkvidlsvnkispsgdssevgfcsnartsvesyepqvleqlhyfrydkyarscrfknk
easfmsvnescykygqtldlsknsiffvkssdfqhlsflkclnlsgnlisqtlngsefqp
laelryldfsnnrldllhstafeelhklevldissnshyfqsegithmlnftknlkvlqk
lmmndndissstsrtmeseslrtlefrgnhldvlwregdnrylqlfknllkleeldiskn
slsflpsgvfdgmppnlknlslaknglksfswkklqclknletldlshnqlttvperlsn
csrslknlilknnqirsltkyflqdafqlryldlssnkiqmiqktsfpenvlnnlkmlll
hhnrflctcdavwfvwwvnhtevtipylatdvtcvgpgahkgqsvisldlytceldltnl
ilfslsisvslflmvmmtashlyfwdvwyiyhfckakikgyqrlispdccydafivydtk
dpavtewvlaelvakledprekhfnlcleerdwlpgqpvlenlsqsiqlskktvfvmtdk
yaktenfkiafylshqrlmdekvdviiliflekpfqkskflqlrkrlcgssvlewptnpq
ahpyfwqclknalatdnhvaysqvfketv

    Sequence, based on observed residues (ATOM records):
    >7cynB (B:)
pktlpcdvtldvpknhvivdctdkhlteipggiptnttnltltinhipdispasfhrldh
lveidfrcncvpiplgsknnmcikrlqikprsfsgltylkslyldgnqlleipqglppsl
qllsleannifsirkenltelanieilylgqncyyrnpcyvsysiekdaflnltklkvls
lkdnnvtavptvlpstltelylynnmiakiqeddfnnlnqlqildlsgncprcynapfpc
apcknnsplqipvnafdaltelkvlrlhsnslqhvpprwfkninklqeldlsqnflakei
gdakflhflpsliqldlsfnfelqvyrasmnlsqafsslkslkilrirgyvfkelksfnl
splhnlqnlevldlgtnfikianlsmfkqfkrlkvidlsvnkispkyarscscykygqtl
dlsknsiffvkssdfqhlsflkclnlsgnlisqtlngsefqplaelryldfsnnrldllh
stafeelhklevldissnshyfqsegithmlnftknlkvlqklmmndndissstsrtmes
eslrtlefrgnhldvlwregdnrylqlfknllkleeldisknslsflpsgvfdgmppnlk
nlslaknglksfswkklqclknletldlshnqlttvperlsncsrslknlilknnqirsl
tkyflqdafqlryldlssnkiqmiqktsfpenvlnnlkmlllhhnrflctcdavwfvwwv
nhtevtipylatdvtcvgpgahkgqsvisldlytceldltnlilfslsisvslflmvmmt
ashlyf

  • Chain 'C':
    Sequence, based on SEQRES records:
    >7cynC (C:)
meaepplypmagaagpqgdedllgvpdgpeapldelvgaypnyneeeeerryyrrkrlgv
lknvlaasaggmltygvylgllqmqlilhydetyrevkygnmglpdidskmlmginvtpi
aallytpvlirffgtkwmmflavgiyalfvstnyweryytlvpsavalgmaivplwasmg
nyitrmaqkyheyshykeqdgqgmkqrpprgshapyllvfqaifysffhlsfacaqlpmi
yflnhylydlnhtlynvqscgtnshgilsgfnktvlrtlprsgnlivvesvlmavaflam
llvlglcgaayrpteeidlrsvgwgnifqlpfkhvrdyrlrhlvpffiysgfevlfactg
ialgygvcsvglerlayllvayslgasaasllgllglwlprpvplvagagvhllltfilf
fwapvprvlqhswilyvaaalwgvgsalnktglstllgilyedkerqdfiftiyhwwqav
aiftvylgsslhmkaklavllvtlvaaavsylrmeqklrrgvaprqpriprpqhkvrgyr
yleednsdesdaegehgdgaeeeappagprpgpepaglgrrpcpyeqaqggdgpeeq

    Sequence, based on observed residues (ATOM records):
    >7cynC (C:)
eeeeerryyrrkrlgvlknvlaasaggmltygvylgllqmqlilhydetyrevkygnmgl
pdidskmlmginvtpiaallytpvlirffgtkwmmflavgiyalfvstnyweryytlvps
avalgmaivplwasmgnyitrmaqkyheyshykeqdgqgmkqrpprgshapyllvfqaif
ysffhlsfacaqlpmiyflnhylydlnhtlynvqscgtnshgilsgfnktvlrtlprsgn
livvesvlmavaflamllvlglcgaayrpteeidlrsvgwgnifqlpfkhvrdyrlrhlv
pffiysgfevlfactgialgygvcsvglerlayllvayslgasaasllgllglwlprpvp
lvagagvhllltfilffwapvprvlqhswilyvaaalwgvgsalnktglstllgilyedk
erqdfiftiyhwwqavaiftvylgsslhmkaklavllvtlvaaavsylrmeqklrrgvap
rqp

  • Chain 'D':
    Sequence, based on SEQRES records:
    >7cynD (D:)
meaepplypmagaagpqgdedllgvpdgpeapldelvgaypnyneeeeerryyrrkrlgv
lknvlaasaggmltygvylgllqmqlilhydetyrevkygnmglpdidskmlmginvtpi
aallytpvlirffgtkwmmflavgiyalfvstnyweryytlvpsavalgmaivplwasmg
nyitrmaqkyheyshykeqdgqgmkqrpprgshapyllvfqaifysffhlsfacaqlpmi
yflnhylydlnhtlynvqscgtnshgilsgfnktvlrtlprsgnlivvesvlmavaflam
llvlglcgaayrpteeidlrsvgwgnifqlpfkhvrdyrlrhlvpffiysgfevlfactg
ialgygvcsvglerlayllvayslgasaasllgllglwlprpvplvagagvhllltfilf
fwapvprvlqhswilyvaaalwgvgsalnktglstllgilyedkerqdfiftiyhwwqav
aiftvylgsslhmkaklavllvtlvaaavsylrmeqklrrgvaprqpriprpqhkvrgyr
yleednsdesdaegehgdgaeeeappagprpgpepaglgrrpcpyeqaqggdgpeeq

    Sequence, based on observed residues (ATOM records):
    >7cynD (D:)
eeeeerryyrrkrlgvlknvlaasaggmltygvylgllqmqlilhydetyrevkygnmgl
pdidskmlmginvtpiaallytpvlirffgtkwmmflavgiyalfvstnyweryytlvps
avalgmaivplwasmgnyitrmaqkyheyshykeqdgqgmkqrpprgshapyllvfqaif
ysffhlsfacaqlpmiyflnhylydlnhtlynvqscgtnshgilsgfnktvlrtlprsgn
livvesvlmavaflamllvlglcgaayrpteeidlrsvgwgnifqlpfkhvrdyrlrhlv
pffiysgfevlfactgialgygvcsvglerlayllvayslgasaasllgllglwlprpvp
lvagagvhllltfilffwapvprvlqhswilyvaaalwgvgsalnktglstllgilyedk
erqdfiftiyhwwqavaiftvylgsslhmkaklavllvtlvaaavsylrmeqklrrgvap
rqp