PDB entry 7cxx

View 7cxx on RCSB PDB site
Description: Structural insights into novel mechanisms of inhibition of the major b-carbonic anhydrase CafB from the pathogenic fungus Aspergillus fumigatus (disulfide-bonded form)
Class: lyase
Keywords: b-class carbonic anhydrase, Zinc metalloenzyme, CafB, Aspergillus fumigatus, oxidative inhibition, zinc-free inactivation, LYASE
Deposited on 2020-09-02, released 2021-03-31
The last revision prior to the SCOPe 2.08 freeze date was dated 2021-03-31, with a file datestamp of 2021-03-26.
Experiment type: XRAY
Resolution: 2 Å
R-factor: N/A
AEROSPACI score: 0.38 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: carbonic anhydrase
    Species: Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) [TaxId:330879]
    Gene: AFUA_8G06550
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d7cxxa_
  • Chain 'B':
    Compound: carbonic anhydrase
    Species: Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) [TaxId:330879]
    Gene: AFUA_8G06550
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d7cxxb_
  • Heterogens: ACT, SO4, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >7cxxA (A:)
mepsdqkvdtvpqylkqsherifennrawvatkmkddpaffeklsagqtpeylyigcsds
rvpaneimgleagevfvhrnianlvpntdlnvmsvinyavrhlqvkhivvcghyhcggvk
aaltpsdlgllnpwlrnvrdvyrlheqeldgiqdataryrrlvelnviescrnviktaav
qqsfherqfpvvhgwifdvetgllrdleidfeetlrdikkiynlapgs

    Sequence, based on observed residues (ATOM records): (download) 
    >7cxxA (A:)
dtvpqylkqsherifennrawvatkmkddpaffeklsagqtpeylyigcsdsrvpaneim
gleagevfvhrnianlvpntdlnvmsvinyavrhlqvkhivvcghyhcggvkaaltpsdl
gllnpwlrnvrdvyrlheqeldgiqdataryrrlvelnviescrnviktaavqqsfherq
fpvvhgwifdvetgllrdleidfeetlrdikkiynl

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >7cxxB (B:)
mepsdqkvdtvpqylkqsherifennrawvatkmkddpaffeklsagqtpeylyigcsds
rvpaneimgleagevfvhrnianlvpntdlnvmsvinyavrhlqvkhivvcghyhcggvk
aaltpsdlgllnpwlrnvrdvyrlheqeldgiqdataryrrlvelnviescrnviktaav
qqsfherqfpvvhgwifdvetgllrdleidfeetlrdikkiynlapgs

    Sequence, based on observed residues (ATOM records): (download) 
    >7cxxB (B:)
rifennrawvatkmkddpaffeklsagqtpeylyigcsdsrvpaneimgleagevfvhrn
ianlvpntdlnvmsvinyavrhlqvkhivvcghyhcggvkaaltpsdlgllnpwlrnvrd
vyrlheqeldgiqdataryrrlvelnviescrnviktaavqqsfherqfpvvhgwifdve
tgllrdleidfeetlrdikki