PDB entry 7cvs

View 7cvs on RCSB PDB site
Description: Crystal structure of the C85A/L194A mutant CLC-ec1 with Fab fragment
Class: transport protein
Keywords: CLC, Chloride, Dimer interface, TRANSPORT PROTEIN
Deposited on 2020-08-27, released 2021-09-01
The last revision prior to the SCOPe 2.08 freeze date was dated 2021-09-01, with a file datestamp of 2021-08-27.
Experiment type: XRAY
Resolution: 3.01 Å
R-factor: N/A
AEROSPACI score: 0.2 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: H(+)/Cl(-) exchange transporter clcA
    Species: Escherichia coli MS 198-1 [TaxId:749549]
    Gene: clcA, eriC, HMPREF9552_04837
    Database cross-references and differences (RAF-indexed):
    • Uniprot D7XDR7 (0-472)
      • engineered mutation (84)
      • engineered mutation (193)
  • Chain 'B':
    Compound: H(+)/Cl(-) exchange transporter clcA
    Species: Escherichia coli MS 198-1 [TaxId:749549]
    Gene: clcA, eriC, HMPREF9552_04837
    Database cross-references and differences (RAF-indexed):
    • Uniprot D7XDR7 (0-472)
      • engineered mutation (84)
      • engineered mutation (193)
  • Chain 'C':
    Compound: antibody fab fragment heavy chain
    Species: Mus musculus [TaxId:10090]
    Database cross-references and differences (RAF-indexed):
    • PDB 7CVS (0-221)
    Domains in SCOPe 2.08: d7cvsc_
  • Chain 'D':
    Compound: antibody fab fragment light chain
    Species: Mus musculus [TaxId:10090]
    Database cross-references and differences (RAF-indexed):
    • PDB 7CVS (0-210)
    Domains in SCOPe 2.08: d7cvsd_
  • Chain 'E':
    Compound: antibody fab fragment heavy chain
    Species: Mus musculus [TaxId:10090]
    Database cross-references and differences (RAF-indexed):
    • PDB 7CVS (0-221)
    Domains in SCOPe 2.08: d7cvse_
  • Chain 'F':
    Compound: antibody fab fragment light chain
    Species: Mus musculus [TaxId:10090]
    Database cross-references and differences (RAF-indexed):
    • PDB 7CVS (0-210)
    Domains in SCOPe 2.08: d7cvsf_
  • Heterogens: CL

PDB Chain Sequences:

  • Chain 'A':
    No sequence available.

  • Chain 'B':
    No sequence available.

  • Chain 'C':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >7cvsC (C:)
evrllesggglvqpggslklscaasgfdysrywmswvrqapgkglkwigeinpvsstiny
tpslkdkfiisrdnakdtlylqiskvrsedtalyycarlyygygywyfdvwgagttvtvs
sakttppsvyplapgsaaaaasmvtlgclvkgyfpepvtvtwnsgslaagvhtfpavlqa
alytlsssvtvpssswpsetvtcnvahpasstkvdkkivpra

  • Chain 'D':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >7cvsD (D:)
divltqspaimsaapgdkvtmtcsasssvsyihwyqqksgtspkrwiydtskltsgvpvr
fsgsgsgtsysltintmeaedaatyycqqwsshpqtfgggtkleilradaaptvsifpps
seqltsggasvvcflnnfypkdinvkwkidgserqngvlnswtdqdskdstysmsstltl
tkdeyerhnsytceathktstspivksfnra

  • Chain 'E':
    Sequence, based on SEQRES records: (download) 
    >7cvsE (E:)
evrllesggglvqpggslklscaasgfdysrywmswvrqapgkglkwigeinpvsstiny
tpslkdkfiisrdnakdtlylqiskvrsedtalyycarlyygygywyfdvwgagttvtvs
sakttppsvyplapgsaaaaasmvtlgclvkgyfpepvtvtwnsgslaagvhtfpavlqa
alytlsssvtvpssswpsetvtcnvahpasstkvdkkivpra

    Sequence, based on observed residues (ATOM records): (download) 
    >7cvsE (E:)
vrllesggglvqpggslklscaasgfdysrywmswvrqapgkglkwigeinpvsstinyt
pslkdkfiisrdnakdtlylqiskvrsedtalyycarlyygygywyfdvwgagttvtvss
akttppsvyplapgsaaaaasmvtlgclvkgyfpepvtvtwnsgslaagvhtfpavlqaa
lytlsssvtvpssswpsetvtcnvahpasstkvdkkivpra

  • Chain 'F':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >7cvsF (F:)
divltqspaimsaapgdkvtmtcsasssvsyihwyqqksgtspkrwiydtskltsgvpvr
fsgsgsgtsysltintmeaedaatyycqqwsshpqtfgggtkleilradaaptvsifpps
seqltsggasvvcflnnfypkdinvkwkidgserqngvlnswtdqdskdstysmsstltl
tkdeyerhnsytceathktstspivksfnra