PDB entry 7cp0

View 7cp0 on RCSB PDB site
Description: Crystal Structure of double mutant Y115E Y117E human Secretory Glutaminyl Cyclase
Class: transferase
Keywords: Glutaminyl-peptide cyclotransferase, sQC, Alzheimer's disease, Pyroglutamate, TRANSFERASE
Deposited on 2020-08-05, released 2021-01-13
The last revision prior to the SCOPe 2.08 freeze date was dated 2021-01-20, with a file datestamp of 2021-01-15.
Experiment type: XRAY
Resolution: 1.7 Å
R-factor: N/A
AEROSPACI score: 0.49 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Glutaminyl-peptide cyclotransferase
    Species: Homo sapiens [TaxId:9606]
    Gene: QPCT
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q16769 (0-326)
      • engineered mutation (80)
      • engineered mutation (82)
    Domains in SCOPe 2.08: d7cp0a_
  • Chain 'B':
    Compound: Glutaminyl-peptide cyclotransferase
    Species: Homo sapiens [TaxId:9606]
    Gene: QPCT
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q16769 (0-326)
      • engineered mutation (80)
      • engineered mutation (82)
    Domains in SCOPe 2.08: d7cp0b_
  • Chain 'C':
    Compound: Glutaminyl-peptide cyclotransferase
    Species: Homo sapiens [TaxId:9606]
    Gene: QPCT
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q16769 (0-326)
      • engineered mutation (80)
      • engineered mutation (82)
    Domains in SCOPe 2.08: d7cp0c_
  • Heterogens: ZN, SO4, EDO, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >7cp0A (A:)
awpeeknyhqpailnssalrqiaegtsisemwqndlqpllierypgspgsyaarqhimqr
iqrlqadwvleidtflsqtpegersfsniistlnptakrhlvlachydskyfshwnnrvf
vgatdsavpcammlelaraldkkllslktvsdskpdlslqliffdgeeaflhwspqdsly
gsrhlaakmastphppgargtsqlhgmdllvlldligapnptfpnffpnsarwferlqai
ehelhelgllkdhslegryfqnysyggviqddhipflrrgvpvlhlipspfpevwhtmdd
neenldestidnlnkilqvfvleylhl

  • Chain 'B':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >7cp0B (B:)
awpeeknyhqpailnssalrqiaegtsisemwqndlqpllierypgspgsyaarqhimqr
iqrlqadwvleidtflsqtpegersfsniistlnptakrhlvlachydskyfshwnnrvf
vgatdsavpcammlelaraldkkllslktvsdskpdlslqliffdgeeaflhwspqdsly
gsrhlaakmastphppgargtsqlhgmdllvlldligapnptfpnffpnsarwferlqai
ehelhelgllkdhslegryfqnysyggviqddhipflrrgvpvlhlipspfpevwhtmdd
neenldestidnlnkilqvfvleylhl

  • Chain 'C':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >7cp0C (C:)
awpeeknyhqpailnssalrqiaegtsisemwqndlqpllierypgspgsyaarqhimqr
iqrlqadwvleidtflsqtpegersfsniistlnptakrhlvlachydskyfshwnnrvf
vgatdsavpcammlelaraldkkllslktvsdskpdlslqliffdgeeaflhwspqdsly
gsrhlaakmastphppgargtsqlhgmdllvlldligapnptfpnffpnsarwferlqai
ehelhelgllkdhslegryfqnysyggviqddhipflrrgvpvlhlipspfpevwhtmdd
neenldestidnlnkilqvfvleylhl