PDB entry 7cnl

View 7cnl on RCSB PDB site
Description: Crystal structure of TEAD3 in complex with VT105
Class: DNA binding protein
Keywords: TEAD, inhibitor, palmitoylation, Hippo pathway, DNA BINDING PROTEIN
Deposited on 2020-08-01, released 2021-04-28
The last revision prior to the SCOPe 2.08 freeze date was dated 2021-06-16, with a file datestamp of 2021-06-11.
Experiment type: XRAY
Resolution: 2.6 Å
R-factor: N/A
AEROSPACI score: 0.26 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Transcriptional enhancer factor TEF-5
    Species: Homo sapiens [TaxId:9606]
    Gene: TEAD3, TEAD5, TEF5
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d7cnla_
  • Chain 'B':
    Compound: Transcriptional enhancer factor TEF-5
    Species: Homo sapiens [TaxId:9606]
    Gene: TEAD3, TEAD5, TEF5
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d7cnlb_
  • Chain 'C':
    Compound: Transcriptional enhancer factor TEF-5
    Species: Homo sapiens [TaxId:9606]
    Gene: TEAD3, TEAD5, TEF5
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d7cnlc_
  • Chain 'D':
    Compound: Transcriptional enhancer factor TEF-5
    Species: Homo sapiens [TaxId:9606]
    Gene: TEAD3, TEAD5, TEF5
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d7cnld_
  • Heterogens: G9C, G9O, PO4, CL, TRS, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >7cnlA (A:)
gqdrtiassrlrlleysafmevqrdpdtyskhlfvhigqtnpafsdppleavdvrqiydk
fpekkgglkelyekgppnafflvkfwadlnstiqegpgafygvssqyssadsmtisvstk
vcsfgkqvvekveteyarlengrfvyrihrspmceyminfihklkhlpekymmnsvlenf
tilqvvtsrdsqetllviafvfevstsehgaqhhvyklvkd

    Sequence, based on observed residues (ATOM records): (download) 
    >7cnlA (A:)
tiassrlrlleysafmevqrdpdtyskhlfvhigdppleavdvrqiydkfpekkgglkel
yekgppnafflvkfwadlnstiqegpgafygvssqyssadsmtisvstkvcsfgkqvvek
veteyarlengrfvyrihrspmceyminfihklkhlpekymmnsvlenftilqvvtsrds
qetllviafvfevstsehgaqhhvyklvkd

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >7cnlB (B:)
gqdrtiassrlrlleysafmevqrdpdtyskhlfvhigqtnpafsdppleavdvrqiydk
fpekkgglkelyekgppnafflvkfwadlnstiqegpgafygvssqyssadsmtisvstk
vcsfgkqvvekveteyarlengrfvyrihrspmceyminfihklkhlpekymmnsvlenf
tilqvvtsrdsqetllviafvfevstsehgaqhhvyklvkd

    Sequence, based on observed residues (ATOM records): (download) 
    >7cnlB (B:)
rtiassrlrlleysafmevqrdpdtyskhlfvhigqtnpafsdppleavdvrqiydkfpe
kkgglkelyekgppnafflvkfwadlnstiqegpgafygvssqyssadsmtisvstkvcs
fgkqvvekveteyarlengrfvyrihrspmceyminfihklkhlpekymmnsvlenftil
qvvtsrdsqetllviafvfevstsehgaqhhvyklvkd

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >7cnlC (C:)
gqdrtiassrlrlleysafmevqrdpdtyskhlfvhigqtnpafsdppleavdvrqiydk
fpekkgglkelyekgppnafflvkfwadlnstiqegpgafygvssqyssadsmtisvstk
vcsfgkqvvekveteyarlengrfvyrihrspmceyminfihklkhlpekymmnsvlenf
tilqvvtsrdsqetllviafvfevstsehgaqhhvyklvkd

    Sequence, based on observed residues (ATOM records): (download) 
    >7cnlC (C:)
rtiassrlrlleysafmevqrdpdtyskhlfvhigqdppleavdvrqiydkfpekkgglk
elyekgppnafflvkfwadlnspgafygvssqyssadsmtisvstkvcsfgkqvvekvet
eyarlengrfvyrihrspmceyminfihklkhlpekymmnsvlenftilqvvtsrdsqet
llviafvfevstsehgaqhhvyklvk

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >7cnlD (D:)
gqdrtiassrlrlleysafmevqrdpdtyskhlfvhigqtnpafsdppleavdvrqiydk
fpekkgglkelyekgppnafflvkfwadlnstiqegpgafygvssqyssadsmtisvstk
vcsfgkqvvekveteyarlengrfvyrihrspmceyminfihklkhlpekymmnsvlenf
tilqvvtsrdsqetllviafvfevstsehgaqhhvyklvkd

    Sequence, based on observed residues (ATOM records): (download) 
    >7cnlD (D:)
rtiassrlrlleysafmevqrdpdtyskhlfvhigppleavdvrqiydkfpekkgglkel
yekgppnafflvkfwadlnstiqegpgafygvssqyssadsmtisvstkvcsfgkqvvek
veteyarlengrfvyrihrspmceyminfihklkhlpekymmnsvlenftilqvvtsrds
qetllviafvfevstsehgaqhhvyklvkd