PDB entry 7cme

View 7cme on RCSB PDB site
Description: Crystal structure of human P-cadherin MEC12 (X dimer) in complex with 2-(5-chloro-2-methyl-1H-indol-3-yl)ethan-1-amine (inhibitor)
Class: cell adhesion
Keywords: inhibitor, complex, CELL ADHESION
Deposited on 2020-07-27, released 2021-09-15
The last revision prior to the SCOPe 2.08 freeze date was dated 2021-09-15, with a file datestamp of 2021-09-10.
Experiment type: XRAY
Resolution: 2.45 Å
R-factor: N/A
AEROSPACI score: 0.28 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Cadherin-3
    Species: Homo sapiens [TaxId:9606]
    Gene: Cdh3, Cdhp
    Database cross-references and differences (RAF-indexed):
    • Uniprot P22223 (1-213)
      • initiating methionine (0)
    Domains in SCOPe 2.08: d7cmea1, d7cmea2, d7cmea3
  • Chain 'B':
    Compound: Cadherin-3
    Species: Homo sapiens [TaxId:9606]
    Gene: Cdh3, Cdhp
    Database cross-references and differences (RAF-indexed):
    • Uniprot P22223 (1-213)
      • initiating methionine (0)
    Domains in SCOPe 2.08: d7cmeb1, d7cmeb2, d7cmeb3
  • Heterogens: G60, DMS, CA, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >7cmeA (A:)
mdwvvapisvpengkgpfpqrlnqlksnkdrdtkifysitgpgadsppegvfaveketgw
lllnkpldreeiakyelfghavsengasvedpmnisiivtdqndhkpkftqdtfrgsvle
gvlpgtsvmqvtatdeddaiytyngvvaysihsqepkdphdlmftihrstgtisvissgl
drekvpeytltiqatdmdgdgstttavavveild

  • Chain 'B':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >7cmeB (B:)
mdwvvapisvpengkgpfpqrlnqlksnkdrdtkifysitgpgadsppegvfaveketgw
lllnkpldreeiakyelfghavsengasvedpmnisiivtdqndhkpkftqdtfrgsvle
gvlpgtsvmqvtatdeddaiytyngvvaysihsqepkdphdlmftihrstgtisvissgl
drekvpeytltiqatdmdgdgstttavavveild