PDB entry 7cmd

View 7cmd on RCSB PDB site
Description: Crystal structure of the SARS-CoV-2 PLpro with GRL0617
Class: viral protein
Keywords: papain like protein;inhibitor, VIRAL PROTEIN
Deposited on 2020-07-27, released 2020-09-02
The last revision prior to the SCOPe 2.08 freeze date was dated 2021-03-10, with a file datestamp of 2021-03-05.
Experiment type: XRAY
Resolution: 2.59 Å
R-factor: N/A
AEROSPACI score: 0.25 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: non-structural protein 3
    Species: Severe acute respiratory syndrome coronavirus 2 [TaxId:2697049]
    Gene: rep, 1a-1b
    Database cross-references and differences (RAF-indexed):
    • Uniprot P0DTD1 (1-End)
      • expression tag (0)
    Domains in SCOPe 2.08: d7cmda1, d7cmda2, d7cmda3
  • Chain 'B':
    Compound: non-structural protein 3
    Species: Severe acute respiratory syndrome coronavirus 2 [TaxId:2697049]
    Gene: rep, 1a-1b
    Database cross-references and differences (RAF-indexed):
    • Uniprot P0DTD1 (1-End)
      • expression tag (0)
    Domains in SCOPe 2.08: d7cmdb1, d7cmdb2, d7cmdb3
  • Chain 'C':
    Compound: non-structural protein 3
    Species: Severe acute respiratory syndrome coronavirus 2 [TaxId:2697049]
    Gene: rep, 1a-1b
    Database cross-references and differences (RAF-indexed):
    • Uniprot P0DTD1 (1-End)
      • expression tag (0)
    Domains in SCOPe 2.08: d7cmdc1, d7cmdc2, d7cmdc3
  • Chain 'D':
    Compound: non-structural protein 3
    Species: Severe acute respiratory syndrome coronavirus 2 [TaxId:2697049]
    Gene: rep, 1a-1b
    Database cross-references and differences (RAF-indexed):
    • Uniprot P0DTD1 (1-End)
      • expression tag (0)
    Domains in SCOPe 2.08: d7cmdd1, d7cmdd2, d7cmdd3
  • Heterogens: TTT, ZN, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >7cmdA (A:)
aevrtikvfttvdninlhtqvvdmsmtygqqfgptyldgadvtkikphnshegktfyvlp
nddtlrveafeyyhttdpsflgrymsalnhtkkwkypqvngltsikwadnncylatallt
lqqielkfnppalqdayyrarageaanfcalilaycnktvgelgdvretmsylfqhanld
sckrvlnvvcktcgqqqttlkgveavmymgtlsyeqfkkgvqipctcgkqatkylvqqes
pfvmmsappaqyelkhgtftcaseytgnyqcghykhitsketlycidgalltksseykgp
itdvfykensytttikpvt

    Sequence, based on observed residues (ATOM records): (download) 
    >7cmdA (A:)
aevrtikvfttvdninlhtqvvdmsmtygqqfgptyldgadvtkikphnshegktfyvlp
nddtlrveafeyyhttdpsflgrymsalnhtkkwkypqvngltsikwadnncylatallt
lqqielkfnppalqdayyrarageaanfcalilaycnktvgelgdvretmsylfqhanld
sckrvlnvvcktcgqqqttlkgveavmymgtlsyeqfkkgvtkylvqqespfvmmsappa
qyelkhgtftcaseytgnyqcghykhitsketlycidgalltksseykgpitdvfykens
ytttik

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >7cmdB (B:)
aevrtikvfttvdninlhtqvvdmsmtygqqfgptyldgadvtkikphnshegktfyvlp
nddtlrveafeyyhttdpsflgrymsalnhtkkwkypqvngltsikwadnncylatallt
lqqielkfnppalqdayyrarageaanfcalilaycnktvgelgdvretmsylfqhanld
sckrvlnvvcktcgqqqttlkgveavmymgtlsyeqfkkgvqipctcgkqatkylvqqes
pfvmmsappaqyelkhgtftcaseytgnyqcghykhitsketlycidgalltksseykgp
itdvfykensytttikpvt

    Sequence, based on observed residues (ATOM records): (download) 
    >7cmdB (B:)
aevrtikvfttvdninlhtqvvdmsmtygqqfgptyldgadvtkikphnshegktfyvlp
nddtlrveafeyyhttdpsflgrymsalnhtkkwkypqvngltsikwadnncylatallt
lqqielkfnppalqdayyrarageaanfcalilaycnktvgelgdvretmsylfqhanld
sckrvlnvvcktcgqqqttlkgveavmymgtlsyeqfkkgvqitkylvqqespfvmmsap
paqyelkhgtftcaseytgnyqcghykhitsketlycidgalltksseykgpitdvfyke
nsytttik

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >7cmdC (C:)
aevrtikvfttvdninlhtqvvdmsmtygqqfgptyldgadvtkikphnshegktfyvlp
nddtlrveafeyyhttdpsflgrymsalnhtkkwkypqvngltsikwadnncylatallt
lqqielkfnppalqdayyrarageaanfcalilaycnktvgelgdvretmsylfqhanld
sckrvlnvvcktcgqqqttlkgveavmymgtlsyeqfkkgvqipctcgkqatkylvqqes
pfvmmsappaqyelkhgtftcaseytgnyqcghykhitsketlycidgalltksseykgp
itdvfykensytttikpvt

    Sequence, based on observed residues (ATOM records): (download) 
    >7cmdC (C:)
aevrtikvfttvdninlhtqvvdmsmtygqqfgptyldgadvtkikphnshegktfyvlp
nddtlrveafeyyhttdpsflgrymsalnhtkkwkypqvngltsikwadnncylatallt
lqqielkfnppalqdayyrarageaanfcalilaycnktvgelgdvretmsylfqhanld
sckrvlnvvcktcgqqqttlkgveavmymgtlsyeqfkkgvqiptkylvqqespfvmmsa
ppaqyelkhgtftcaseytgnyqcghykhitsketlycidgalltksseykgpitdvfyk
ensyttti

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >7cmdD (D:)
aevrtikvfttvdninlhtqvvdmsmtygqqfgptyldgadvtkikphnshegktfyvlp
nddtlrveafeyyhttdpsflgrymsalnhtkkwkypqvngltsikwadnncylatallt
lqqielkfnppalqdayyrarageaanfcalilaycnktvgelgdvretmsylfqhanld
sckrvlnvvcktcgqqqttlkgveavmymgtlsyeqfkkgvqipctcgkqatkylvqqes
pfvmmsappaqyelkhgtftcaseytgnyqcghykhitsketlycidgalltksseykgp
itdvfykensytttikpvt

    Sequence, based on observed residues (ATOM records): (download) 
    >7cmdD (D:)
aevrtikvfttvdninlhtqvvdmsmtygqqfgptyldgadvtkikphnshegktfyvlp
nddtlrveafeyyhttdpsflgrymsalnhtkkwkypqvngltsikwadnncylatallt
lqqielkfnppalqdayyrarageaanfcalilaycnktvgelgdvretmsylfqhanld
sckrvlnvvcktcgqqqttlkgveavmymgtlsyeqfkkgvqtkylvqqespfvmmsapp
aqyelkhgtftcaseytgnyqcghykhitsketlycidgalltksseykgpitdvfyken
sytttik