SCOPe 2.08: Structural Classification of Proteins

PDB entry 7cm7

View 7cm7 on RCSB PDB site
Description: nad+-bound sarm1 e642a in the self-inhibited state
Deposited on 2020-07-25, released 2020-10-21
The last revision was dated 2021-01-13, with a file datestamp of 2021-01-08.
Experiment type: EM
Resolution: 2.6 Å
R-factor: N/A
AEROSPACI score: 0.3 (click here for full SPACI score report)

Chains and heterogens:

Chain 'A':
Compound: NAD(+) hydrolase SARM1
Species: Homo sapiens [TaxId:9606]
Gene: SARM1, KIAA0524, SAMD2, SARM
Database cross-references and differences (RAF-indexed):
- Uniprot Q6SZW1
  - engineered mutation (641)
Chain 'B':
Compound: NAD(+) hydrolase SARM1
Species: Homo sapiens [TaxId:9606]
Gene: SARM1, KIAA0524, SAMD2, SARM
Database cross-references and differences (RAF-indexed):
- Uniprot Q6SZW1
  - engineered mutation (641)
Chain 'C':
Compound: NAD(+) hydrolase SARM1
Species: Homo sapiens [TaxId:9606]
Gene: SARM1, KIAA0524, SAMD2, SARM
Database cross-references and differences (RAF-indexed):
- Uniprot Q6SZW1
  - engineered mutation (641)
Chain 'D':
Compound: NAD(+) hydrolase SARM1
Species: Homo sapiens [TaxId:9606]
Gene: SARM1, KIAA0524, SAMD2, SARM
Database cross-references and differences (RAF-indexed):
- Uniprot Q6SZW1
  - engineered mutation (641)
Chain 'E':
Compound: NAD(+) hydrolase SARM1
Species: Homo sapiens [TaxId:9606]
Gene: SARM1, KIAA0524, SAMD2, SARM
Database cross-references and differences (RAF-indexed):
- Uniprot Q6SZW1
  - engineered mutation (641)
Chain 'F':
Compound: NAD(+) hydrolase SARM1
Species: Homo sapiens [TaxId:9606]
Gene: SARM1, KIAA0524, SAMD2, SARM
Database cross-references and differences (RAF-indexed):
- Uniprot Q6SZW1
  - engineered mutation (641)
Chain 'G':
Compound: NAD(+) hydrolase SARM1
Species: Homo sapiens [TaxId:9606]
Gene: SARM1, KIAA0524, SAMD2, SARM
Database cross-references and differences (RAF-indexed):
- Uniprot Q6SZW1
  - engineered mutation (641)
Chain 'H':
Compound: NAD(+) hydrolase SARM1
Species: Homo sapiens [TaxId:9606]
Gene: SARM1, KIAA0524, SAMD2, SARM
Database cross-references and differences (RAF-indexed):
- Uniprot Q6SZW1
  - engineered mutation (641)
Heterogens: NAD

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

Chain 'A':
Sequence, based on SEQRES records:

>7cm7A (A:)
mvltlllsayklcrffamsgprpgaerlavpgpdggggtgpwwaaggrgprevspgagte
vqdaleralpelqqalsalkqaggaravgaglaevfqlveeawllpavgrevaqglcdai
rldggldlllrllqapeletrvqaarlleqilvaenrdrvariglgvilnlakerepvel
arsvagilehmfkhseetcqrlvaaggldavlywcrrtdpallrhcalalgncalhggqa
vqrrmvekraaewlfplafskedellrlhaclavavlatnkevereversgtlalveplv
asldpgrfarclvdasdtsqgrgpddlqrlvplldsnrleaqcigafylcaeaaikslqg
ktkvfsdigaiqslkrlvsystngtksalakralrllgeevprpilpsvpswkeaevqtw
lqqigfskycesfreqqvdgdlllrlteeelqtdlgmksgitrkrffreltelktfanys
tcdrsnladwlgsldprfrqytyglvscgldrsllhrvseqqlledcgihlgvhrarilt
aaremlhsplpctggkpsgdtpdvfisyrrnsgsqlasllkvhlqlhgfsvfidveklea
gkfedkliqsvmgarnfvlvlspgaldkcmqdhdckdwvhkaivtalscgknivpiidgf
ewpepqvlpedmqavltfngikwsheyqeatiekiirflqgrssrdssagsdtslegaap
mgptsnslevlfq