PDB entry 7cm6

View 7cm6 on RCSB PDB site
Description: nad+-bound sarm1 in the self-inhibited state
Deposited on 2020-07-25, released 2020-10-21
The last revision was dated 2021-01-13, with a file datestamp of 2021-01-08.
Experiment type: EM
Resolution: 3 Å
R-factor: N/A
AEROSPACI score: 0.25 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: NAD(+) hydrolase SARM1
    Species: Homo sapiens [TaxId:9606]
    Gene: SARM1, KIAA0524, SAMD2, SARM
    Database cross-references and differences (RAF-indexed):
  • Chain 'B':
    Compound: NAD(+) hydrolase SARM1
    Species: Homo sapiens [TaxId:9606]
    Gene: SARM1, KIAA0524, SAMD2, SARM
    Database cross-references and differences (RAF-indexed):
  • Chain 'C':
    Compound: NAD(+) hydrolase SARM1
    Species: Homo sapiens [TaxId:9606]
    Gene: SARM1, KIAA0524, SAMD2, SARM
    Database cross-references and differences (RAF-indexed):
  • Chain 'D':
    Compound: NAD(+) hydrolase SARM1
    Species: Homo sapiens [TaxId:9606]
    Gene: SARM1, KIAA0524, SAMD2, SARM
    Database cross-references and differences (RAF-indexed):
  • Chain 'E':
    Compound: NAD(+) hydrolase SARM1
    Species: Homo sapiens [TaxId:9606]
    Gene: SARM1, KIAA0524, SAMD2, SARM
    Database cross-references and differences (RAF-indexed):
  • Chain 'F':
    Compound: NAD(+) hydrolase SARM1
    Species: Homo sapiens [TaxId:9606]
    Gene: SARM1, KIAA0524, SAMD2, SARM
    Database cross-references and differences (RAF-indexed):
  • Chain 'G':
    Compound: NAD(+) hydrolase SARM1
    Species: Homo sapiens [TaxId:9606]
    Gene: SARM1, KIAA0524, SAMD2, SARM
    Database cross-references and differences (RAF-indexed):
  • Chain 'H':
    Compound: NAD(+) hydrolase SARM1
    Species: Homo sapiens [TaxId:9606]
    Gene: SARM1, KIAA0524, SAMD2, SARM
    Database cross-references and differences (RAF-indexed):
  • Heterogens: NAD

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >7cm6A (A:)
mvltlllsayklcrffamsgprpgaerlavpgpdggggtgpwwaaggrgprevspgagte
vqdaleralpelqqalsalkqaggaravgaglaevfqlveeawllpavgrevaqglcdai
rldggldlllrllqapeletrvqaarlleqilvaenrdrvariglgvilnlakerepvel
arsvagilehmfkhseetcqrlvaaggldavlywcrrtdpallrhcalalgncalhggqa
vqrrmvekraaewlfplafskedellrlhaclavavlatnkevereversgtlalveplv
asldpgrfarclvdasdtsqgrgpddlqrlvplldsnrleaqcigafylcaeaaikslqg
ktkvfsdigaiqslkrlvsystngtksalakralrllgeevprpilpsvpswkeaevqtw
lqqigfskycesfreqqvdgdlllrlteeelqtdlgmksgitrkrffreltelktfanys
tcdrsnladwlgsldprfrqytyglvscgldrsllhrvseqqlledcgihlgvhrarilt
aaremlhsplpctggkpsgdtpdvfisyrrnsgsqlasllkvhlqlhgfsvfidveklea
gkfedkliqsvmgarnfvlvlspgaldkcmqdhdckdwvhkeivtalscgknivpiidgf
ewpepqvlpedmqavltfngikwsheyqeatiekiirflqgrssrdssagsdtslegaap
mgptsnslevlfq

    Sequence, based on observed residues (ATOM records):
    >7cm6A (A:)
vqdaleralpelqqalsalkqaggaravgaglaevfqlveeawllpavgrevaqglcdai
rldggldlllrllqapeletrvqaarlleqilvaenrdrvariglgvilnlakerepvel
arsvagilehmfkhseetcqrlvaaggldavlywcrrtdpallrhcalalgncalhggqa
vqrrmvekraaewlfplafskedellrlhaclavavlatnkevereversgtlalveplv
asldpgrfarclqgrgpddlqrlvplldsnrleaqcigafylcaeaaikslqgktkvfsd
igaiqslkrlvsystngtksalakralrllgeevprpilpsvpswkeaevqtwlqqigfs
kycesfreqqvdgdlllrlteeelqtdlgmksgitrkrffreltelktfanystcdrsnl
adwlgsldprfrqytyglvscgldrsllhrvseqqlledcgihlgvhrariltaaremlh
tpdvfisyrrnsgsqlasllkvhlqlhgfsvfidedkliqsvmgarnfvlvlspgaldkc
mqdhdckdwvhkeivtalscgknivpiidgfewpepqvlpedmqavltfngikwsheyqe
atiekiirflq

  • Chain 'B':
    Sequence, based on SEQRES records:
    >7cm6B (B:)
mvltlllsayklcrffamsgprpgaerlavpgpdggggtgpwwaaggrgprevspgagte
vqdaleralpelqqalsalkqaggaravgaglaevfqlveeawllpavgrevaqglcdai
rldggldlllrllqapeletrvqaarlleqilvaenrdrvariglgvilnlakerepvel
arsvagilehmfkhseetcqrlvaaggldavlywcrrtdpallrhcalalgncalhggqa
vqrrmvekraaewlfplafskedellrlhaclavavlatnkevereversgtlalveplv
asldpgrfarclvdasdtsqgrgpddlqrlvplldsnrleaqcigafylcaeaaikslqg
ktkvfsdigaiqslkrlvsystngtksalakralrllgeevprpilpsvpswkeaevqtw
lqqigfskycesfreqqvdgdlllrlteeelqtdlgmksgitrkrffreltelktfanys
tcdrsnladwlgsldprfrqytyglvscgldrsllhrvseqqlledcgihlgvhrarilt
aaremlhsplpctggkpsgdtpdvfisyrrnsgsqlasllkvhlqlhgfsvfidveklea
gkfedkliqsvmgarnfvlvlspgaldkcmqdhdckdwvhkeivtalscgknivpiidgf
ewpepqvlpedmqavltfngikwsheyqeatiekiirflqgrssrdssagsdtslegaap
mgptsnslevlfq

    Sequence, based on observed residues (ATOM records):
    >7cm6B (B:)
vqdaleralpelqqalsalkqaggaravgaglaevfqlveeawllpavgrevaqglcdai
rldggldlllrllqapeletrvqaarlleqilvaenrdrvariglgvilnlakerepvel
arsvagilehmfkhseetcqrlvaaggldavlywcrrtdpallrhcalalgncalhggqa
vqrrmvekraaewlfplafskedellrlhaclavavlatnkevereversgtlalveplv
asldpgrfarclqgrgpddlqrlvplldsnrleaqcigafylcaeaaikslqgktkvfsd
igaiqslkrlvsystngtksalakralrllgeevprpilpsvpswkeaevqtwlqqigfs
kycesfreqqvdgdlllrlteeelqtdlgmksgitrkrffreltelktfanystcdrsnl
adwlgsldprfrqytyglvscgldrsllhrvseqqlledcgihlgvhrariltaaremlh
tpdvfisyrrnsgsqlasllkvhlqlhgfsvfidedkliqsvmgarnfvlvlspgaldkc
mqdhdckdwvhkeivtalscgknivpiidgfewpepqvlpedmqavltfngikwsheyqe
atiekiirflq

  • Chain 'C':
    Sequence, based on SEQRES records:
    >7cm6C (C:)
mvltlllsayklcrffamsgprpgaerlavpgpdggggtgpwwaaggrgprevspgagte
vqdaleralpelqqalsalkqaggaravgaglaevfqlveeawllpavgrevaqglcdai
rldggldlllrllqapeletrvqaarlleqilvaenrdrvariglgvilnlakerepvel
arsvagilehmfkhseetcqrlvaaggldavlywcrrtdpallrhcalalgncalhggqa
vqrrmvekraaewlfplafskedellrlhaclavavlatnkevereversgtlalveplv
asldpgrfarclvdasdtsqgrgpddlqrlvplldsnrleaqcigafylcaeaaikslqg
ktkvfsdigaiqslkrlvsystngtksalakralrllgeevprpilpsvpswkeaevqtw
lqqigfskycesfreqqvdgdlllrlteeelqtdlgmksgitrkrffreltelktfanys
tcdrsnladwlgsldprfrqytyglvscgldrsllhrvseqqlledcgihlgvhrarilt
aaremlhsplpctggkpsgdtpdvfisyrrnsgsqlasllkvhlqlhgfsvfidveklea
gkfedkliqsvmgarnfvlvlspgaldkcmqdhdckdwvhkeivtalscgknivpiidgf
ewpepqvlpedmqavltfngikwsheyqeatiekiirflqgrssrdssagsdtslegaap
mgptsnslevlfq

    Sequence, based on observed residues (ATOM records):
    >7cm6C (C:)
vqdaleralpelqqalsalkqaggaravgaglaevfqlveeawllpavgrevaqglcdai
rldggldlllrllqapeletrvqaarlleqilvaenrdrvariglgvilnlakerepvel
arsvagilehmfkhseetcqrlvaaggldavlywcrrtdpallrhcalalgncalhggqa
vqrrmvekraaewlfplafskedellrlhaclavavlatnkevereversgtlalveplv
asldpgrfarclqgrgpddlqrlvplldsnrleaqcigafylcaeaaikslqgktkvfsd
igaiqslkrlvsystngtksalakralrllgeevprpilpsvpswkeaevqtwlqqigfs
kycesfreqqvdgdlllrlteeelqtdlgmksgitrkrffreltelktfanystcdrsnl
adwlgsldprfrqytyglvscgldrsllhrvseqqlledcgihlgvhrariltaaremlh
tpdvfisyrrnsgsqlasllkvhlqlhgfsvfidedkliqsvmgarnfvlvlspgaldkc
mqdhdckdwvhkeivtalscgknivpiidgfewpepqvlpedmqavltfngikwsheyqe
atiekiirflq

  • Chain 'D':
    Sequence, based on SEQRES records:
    >7cm6D (D:)
mvltlllsayklcrffamsgprpgaerlavpgpdggggtgpwwaaggrgprevspgagte
vqdaleralpelqqalsalkqaggaravgaglaevfqlveeawllpavgrevaqglcdai
rldggldlllrllqapeletrvqaarlleqilvaenrdrvariglgvilnlakerepvel
arsvagilehmfkhseetcqrlvaaggldavlywcrrtdpallrhcalalgncalhggqa
vqrrmvekraaewlfplafskedellrlhaclavavlatnkevereversgtlalveplv
asldpgrfarclvdasdtsqgrgpddlqrlvplldsnrleaqcigafylcaeaaikslqg
ktkvfsdigaiqslkrlvsystngtksalakralrllgeevprpilpsvpswkeaevqtw
lqqigfskycesfreqqvdgdlllrlteeelqtdlgmksgitrkrffreltelktfanys
tcdrsnladwlgsldprfrqytyglvscgldrsllhrvseqqlledcgihlgvhrarilt
aaremlhsplpctggkpsgdtpdvfisyrrnsgsqlasllkvhlqlhgfsvfidveklea
gkfedkliqsvmgarnfvlvlspgaldkcmqdhdckdwvhkeivtalscgknivpiidgf
ewpepqvlpedmqavltfngikwsheyqeatiekiirflqgrssrdssagsdtslegaap
mgptsnslevlfq

    Sequence, based on observed residues (ATOM records):
    >7cm6D (D:)
vqdaleralpelqqalsalkqaggaravgaglaevfqlveeawllpavgrevaqglcdai
rldggldlllrllqapeletrvqaarlleqilvaenrdrvariglgvilnlakerepvel
arsvagilehmfkhseetcqrlvaaggldavlywcrrtdpallrhcalalgncalhggqa
vqrrmvekraaewlfplafskedellrlhaclavavlatnkevereversgtlalveplv
asldpgrfarclqgrgpddlqrlvplldsnrleaqcigafylcaeaaikslqgktkvfsd
igaiqslkrlvsystngtksalakralrllgeevprpilpsvpswkeaevqtwlqqigfs
kycesfreqqvdgdlllrlteeelqtdlgmksgitrkrffreltelktfanystcdrsnl
adwlgsldprfrqytyglvscgldrsllhrvseqqlledcgihlgvhrariltaaremlh
tpdvfisyrrnsgsqlasllkvhlqlhgfsvfidedkliqsvmgarnfvlvlspgaldkc
mqdhdckdwvhkeivtalscgknivpiidgfewpepqvlpedmqavltfngikwsheyqe
atiekiirflq

  • Chain 'E':
    Sequence, based on SEQRES records:
    >7cm6E (E:)
mvltlllsayklcrffamsgprpgaerlavpgpdggggtgpwwaaggrgprevspgagte
vqdaleralpelqqalsalkqaggaravgaglaevfqlveeawllpavgrevaqglcdai
rldggldlllrllqapeletrvqaarlleqilvaenrdrvariglgvilnlakerepvel
arsvagilehmfkhseetcqrlvaaggldavlywcrrtdpallrhcalalgncalhggqa
vqrrmvekraaewlfplafskedellrlhaclavavlatnkevereversgtlalveplv
asldpgrfarclvdasdtsqgrgpddlqrlvplldsnrleaqcigafylcaeaaikslqg
ktkvfsdigaiqslkrlvsystngtksalakralrllgeevprpilpsvpswkeaevqtw
lqqigfskycesfreqqvdgdlllrlteeelqtdlgmksgitrkrffreltelktfanys
tcdrsnladwlgsldprfrqytyglvscgldrsllhrvseqqlledcgihlgvhrarilt
aaremlhsplpctggkpsgdtpdvfisyrrnsgsqlasllkvhlqlhgfsvfidveklea
gkfedkliqsvmgarnfvlvlspgaldkcmqdhdckdwvhkeivtalscgknivpiidgf
ewpepqvlpedmqavltfngikwsheyqeatiekiirflqgrssrdssagsdtslegaap
mgptsnslevlfq

    Sequence, based on observed residues (ATOM records):
    >7cm6E (E:)
vqdaleralpelqqalsalkqaggaravgaglaevfqlveeawllpavgrevaqglcdai
rldggldlllrllqapeletrvqaarlleqilvaenrdrvariglgvilnlakerepvel
arsvagilehmfkhseetcqrlvaaggldavlywcrrtdpallrhcalalgncalhggqa
vqrrmvekraaewlfplafskedellrlhaclavavlatnkevereversgtlalveplv
asldpgrfarclqgrgpddlqrlvplldsnrleaqcigafylcaeaaikslqgktkvfsd
igaiqslkrlvsystngtksalakralrllgeevprpilpsvpswkeaevqtwlqqigfs
kycesfreqqvdgdlllrlteeelqtdlgmksgitrkrffreltelktfanystcdrsnl
adwlgsldprfrqytyglvscgldrsllhrvseqqlledcgihlgvhrariltaaremlh
tpdvfisyrrnsgsqlasllkvhlqlhgfsvfidedkliqsvmgarnfvlvlspgaldkc
mqdhdckdwvhkeivtalscgknivpiidgfewpepqvlpedmqavltfngikwsheyqe
atiekiirflq

  • Chain 'F':
    Sequence, based on SEQRES records:
    >7cm6F (F:)
mvltlllsayklcrffamsgprpgaerlavpgpdggggtgpwwaaggrgprevspgagte
vqdaleralpelqqalsalkqaggaravgaglaevfqlveeawllpavgrevaqglcdai
rldggldlllrllqapeletrvqaarlleqilvaenrdrvariglgvilnlakerepvel
arsvagilehmfkhseetcqrlvaaggldavlywcrrtdpallrhcalalgncalhggqa
vqrrmvekraaewlfplafskedellrlhaclavavlatnkevereversgtlalveplv
asldpgrfarclvdasdtsqgrgpddlqrlvplldsnrleaqcigafylcaeaaikslqg
ktkvfsdigaiqslkrlvsystngtksalakralrllgeevprpilpsvpswkeaevqtw
lqqigfskycesfreqqvdgdlllrlteeelqtdlgmksgitrkrffreltelktfanys
tcdrsnladwlgsldprfrqytyglvscgldrsllhrvseqqlledcgihlgvhrarilt
aaremlhsplpctggkpsgdtpdvfisyrrnsgsqlasllkvhlqlhgfsvfidveklea
gkfedkliqsvmgarnfvlvlspgaldkcmqdhdckdwvhkeivtalscgknivpiidgf
ewpepqvlpedmqavltfngikwsheyqeatiekiirflqgrssrdssagsdtslegaap
mgptsnslevlfq

    Sequence, based on observed residues (ATOM records):
    >7cm6F (F:)
vqdaleralpelqqalsalkqaggaravgaglaevfqlveeawllpavgrevaqglcdai
rldggldlllrllqapeletrvqaarlleqilvaenrdrvariglgvilnlakerepvel
arsvagilehmfkhseetcqrlvaaggldavlywcrrtdpallrhcalalgncalhggqa
vqrrmvekraaewlfplafskedellrlhaclavavlatnkevereversgtlalveplv
asldpgrfarclqgrgpddlqrlvplldsnrleaqcigafylcaeaaikslqgktkvfsd
igaiqslkrlvsystngtksalakralrllgeevprpilpsvpswkeaevqtwlqqigfs
kycesfreqqvdgdlllrlteeelqtdlgmksgitrkrffreltelktfanystcdrsnl
adwlgsldprfrqytyglvscgldrsllhrvseqqlledcgihlgvhrariltaaremlh
tpdvfisyrrnsgsqlasllkvhlqlhgfsvfidedkliqsvmgarnfvlvlspgaldkc
mqdhdckdwvhkeivtalscgknivpiidgfewpepqvlpedmqavltfngikwsheyqe
atiekiirflq

  • Chain 'G':
    Sequence, based on SEQRES records:
    >7cm6G (G:)
mvltlllsayklcrffamsgprpgaerlavpgpdggggtgpwwaaggrgprevspgagte
vqdaleralpelqqalsalkqaggaravgaglaevfqlveeawllpavgrevaqglcdai
rldggldlllrllqapeletrvqaarlleqilvaenrdrvariglgvilnlakerepvel
arsvagilehmfkhseetcqrlvaaggldavlywcrrtdpallrhcalalgncalhggqa
vqrrmvekraaewlfplafskedellrlhaclavavlatnkevereversgtlalveplv
asldpgrfarclvdasdtsqgrgpddlqrlvplldsnrleaqcigafylcaeaaikslqg
ktkvfsdigaiqslkrlvsystngtksalakralrllgeevprpilpsvpswkeaevqtw
lqqigfskycesfreqqvdgdlllrlteeelqtdlgmksgitrkrffreltelktfanys
tcdrsnladwlgsldprfrqytyglvscgldrsllhrvseqqlledcgihlgvhrarilt
aaremlhsplpctggkpsgdtpdvfisyrrnsgsqlasllkvhlqlhgfsvfidveklea
gkfedkliqsvmgarnfvlvlspgaldkcmqdhdckdwvhkeivtalscgknivpiidgf
ewpepqvlpedmqavltfngikwsheyqeatiekiirflqgrssrdssagsdtslegaap
mgptsnslevlfq

    Sequence, based on observed residues (ATOM records):
    >7cm6G (G:)
vqdaleralpelqqalsalkqaggaravgaglaevfqlveeawllpavgrevaqglcdai
rldggldlllrllqapeletrvqaarlleqilvaenrdrvariglgvilnlakerepvel
arsvagilehmfkhseetcqrlvaaggldavlywcrrtdpallrhcalalgncalhggqa
vqrrmvekraaewlfplafskedellrlhaclavavlatnkevereversgtlalveplv
asldpgrfarclqgrgpddlqrlvplldsnrleaqcigafylcaeaaikslqgktkvfsd
igaiqslkrlvsystngtksalakralrllgeevprpilpsvpswkeaevqtwlqqigfs
kycesfreqqvdgdlllrlteeelqtdlgmksgitrkrffreltelktfanystcdrsnl
adwlgsldprfrqytyglvscgldrsllhrvseqqlledcgihlgvhrariltaaremlh
tpdvfisyrrnsgsqlasllkvhlqlhgfsvfidedkliqsvmgarnfvlvlspgaldkc
mqdhdckdwvhkeivtalscgknivpiidgfewpepqvlpedmqavltfngikwsheyqe
atiekiirflq

  • Chain 'H':
    Sequence, based on SEQRES records:
    >7cm6H (H:)
mvltlllsayklcrffamsgprpgaerlavpgpdggggtgpwwaaggrgprevspgagte
vqdaleralpelqqalsalkqaggaravgaglaevfqlveeawllpavgrevaqglcdai
rldggldlllrllqapeletrvqaarlleqilvaenrdrvariglgvilnlakerepvel
arsvagilehmfkhseetcqrlvaaggldavlywcrrtdpallrhcalalgncalhggqa
vqrrmvekraaewlfplafskedellrlhaclavavlatnkevereversgtlalveplv
asldpgrfarclvdasdtsqgrgpddlqrlvplldsnrleaqcigafylcaeaaikslqg
ktkvfsdigaiqslkrlvsystngtksalakralrllgeevprpilpsvpswkeaevqtw
lqqigfskycesfreqqvdgdlllrlteeelqtdlgmksgitrkrffreltelktfanys
tcdrsnladwlgsldprfrqytyglvscgldrsllhrvseqqlledcgihlgvhrarilt
aaremlhsplpctggkpsgdtpdvfisyrrnsgsqlasllkvhlqlhgfsvfidveklea
gkfedkliqsvmgarnfvlvlspgaldkcmqdhdckdwvhkeivtalscgknivpiidgf
ewpepqvlpedmqavltfngikwsheyqeatiekiirflqgrssrdssagsdtslegaap
mgptsnslevlfq

    Sequence, based on observed residues (ATOM records):
    >7cm6H (H:)
vqdaleralpelqqalsalkqaggaravgaglaevfqlveeawllpavgrevaqglcdai
rldggldlllrllqapeletrvqaarlleqilvaenrdrvariglgvilnlakerepvel
arsvagilehmfkhseetcqrlvaaggldavlywcrrtdpallrhcalalgncalhggqa
vqrrmvekraaewlfplafskedellrlhaclavavlatnkevereversgtlalveplv
asldpgrfarclqgrgpddlqrlvplldsnrleaqcigafylcaeaaikslqgktkvfsd
igaiqslkrlvsystngtksalakralrllgeevprpilpsvpswkeaevqtwlqqigfs
kycesfreqqvdgdlllrlteeelqtdlgmksgitrkrffreltelktfanystcdrsnl
adwlgsldprfrqytyglvscgldrsllhrvseqqlledcgihlgvhrariltaaremlh
tpdvfisyrrnsgsqlasllkvhlqlhgfsvfidedkliqsvmgarnfvlvlspgaldkc
mqdhdckdwvhkeivtalscgknivpiidgfewpepqvlpedmqavltfngikwsheyqe
atiekiirflq