PDB entry 7ckr

View 7ckr on RCSB PDB site
Description: cryo-em structure of the human mct1/basigin-2 complex in the presence of anti-cancer drug candidate bay-8002 in the outward-open conformation.
Deposited on 2020-07-18, released 2020-12-23
The last revision was dated 2021-02-10, with a file datestamp of 2021-02-05.
Experiment type: EM
Resolution: 3 Å
R-factor: N/A
AEROSPACI score: 0.17 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Monocarboxylate transporter 1
    Species: Homo sapiens [TaxId:9606]
    Gene: SLC16A1, MCT1
    Database cross-references and differences (RAF-indexed):
  • Chain 'B':
    Compound: Basigin
    Species: Homo sapiens [TaxId:9606]
    Gene: BSG, UNQ6505/PRO21383
    Database cross-references and differences (RAF-indexed):
  • Heterogens: G5O

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >7ckrA (A:)
    mppavggpvgytppdggwgwavvigafisigfsyafpksitvffkeiegifhattsevsw
    issimlavmygggpissilvnkygsrivmivggclsgcgliaasfcntvqqlyvcigvig
    glglafnlnpaltmigkyfykrrplanglamagspvflctlaplnqvffgifgwrgsfli
    lgglllnccvagalmrpigpkptkagkdkskaslekagksgvkkdlhdantdligrhpkq
    ekrsvfqtinqfldltlfthrgfllylsgnvimffglfaplvflssygksqhysseksaf
    llsilafvdmvarpsmglvantkpirpriqyffaasvvangvchmlaplsttyvgfcvya
    gffgfafgwlssvlfetlmdlvgpqrfssavglvtiveccpvllgppllgrlndmygdyk
    ytywacgvvliisgiylfigmginyrllakeqkaneqkkeskeeetsidvagkpnevtka
    aespdqkdtdggpkeeespv
    

    Sequence, based on observed residues (ATOM records):
    >7ckrA (A:)
    ggwgwavvigafisigfsyafpksitvffkeiegifhattsevswissimlavmygggpi
    ssilvnkygsrivmivggclsgcgliaasfcntvqqlyvcigvigglglafnlnpaltmi
    gkyfykrrplanglamagspvflctlaplnqvffgifgwrgsflilgglllnccvagalm
    rpigpldltlfthrgfllylsgnvimffglfaplvflssygksqhysseksafllsilaf
    vdmvarpsmglvantkpirpriqyffaasvvangvchmlaplsttyvgfcvyagffgfaf
    gwlssvlfetlmdlvgpqrfssavglvtiveccpvllgppllgrlndmygdykytywacg
    vvliisgiylfigmginyrlla
    

  • Chain 'B':
    Sequence, based on SEQRES records:
    >7ckrB (B:)
    maaalfvllgfallgthgasgaagtvfttvedlgskilltcslndsatevtghrwlkggv
    vlkedalpgqktefkvdsddqwgeyscvflpepmgtaniqlhgpprvkavkssehinege
    tamlvcksesvppvtdwawykitdsedkalmngsesrffvsssqgrselhienlnmeadp
    gqyrcngtsskgsdqaiitlrvrshlaalwpflgivaevlvlvtiifiyekrrkpedvld
    dddagsaplkssgqhqndkgknvrqrnss
    

    Sequence, based on observed residues (ATOM records):
    >7ckrB (B:)
    agtvfttvedlgskilltcslndsatevtghrwlkggvvlkedalpgqktefkvdsddqw
    geyscvflpepmgtaniqlhgpprvkavkssehinegetamlvcksesvppvtdwawyki
    tdsedkalmngsesrffvsssqgrselhienlnmeadpgqyrcngtsskgsdqaiitlrv
    rshlaalwpflgivaevlvlvtiifiyekrrkped