PDB entry 7cja

View 7cja on RCSB PDB site
Description: Crystal structure of TTK kinase domain in complex with compound 28
Class: transferase
Keywords: Kinase MPS1 TTK Structure-guided drug design, TRANSFERASE
Deposited on 2020-07-09, released 2021-05-12
The last revision prior to the SCOPe 2.08 freeze date was dated 2021-06-09, with a file datestamp of 2021-06-04.
Experiment type: XRAY
Resolution: 2.49 Å
R-factor: N/A
AEROSPACI score: 0.27 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Dual specificity protein kinase TTK
    Species: Homo sapiens [TaxId:9606]
    Gene: TTK, MPS1, MPS1L1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P33981 (0-280)
      • expression tag (281-282)
    Domains in SCOPe 2.08: d7cjaa1, d7cjaa2
  • Heterogens: G0U, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >7cjaA (A:)
necisvkgriysilkqigsggsskvfqvlnekkqiyaikyvnleeadnqtldsyrneiay
lnklqqhsdkiirlydyeitdqyiymvmecgnidlnswlkkkksidpwerksywknmlea
vhtihqhgivhsdlkpanflivdgmlklidfgianqmqpdttsvvkdsqvgtvnymppea
ikdmsssrengkskskispksdvwslgcilyymtygktpfqqiinqisklhaiidpnhei
efpdipekdlqdvlkcclkrdpkqrisipellahpyvqiqtle

    Sequence, based on observed residues (ATOM records): (download) 
    >7cjaA (A:)
necisvkgriysilkqigsggsskvfqvlnekkqiyaikyvnleeadnqtldsyrneiay
lnklqqhsdkiirlydyeitdqyiymvmecgnidlnswlkkkksidpwerksywknmlea
vhtihqhgivhsdlkpanflivdgmlklidfgianqmqpdtvgtvnymppeaikdmssis
pksdvwslgcilyymtygktpfqqiinqisklhaiidpnheiefpdipekdlqdvlkccl
krdpkqrisipellahpyvqiqtle