PDB entry 7cj2

View 7cj2 on RCSB PDB site
Description: Crystal structure of the Fab antibody complexed with human YKL-40
Class: immune system
Keywords: Chitin binding protein, Inflammatory response, Fab, antibody-antigen complex, APOPTOSIS, IMMUNE SYSTEM
Deposited on 2020-07-09, released 2021-07-14
The last revision prior to the SCOPe 2.08 freeze date was dated 2021-07-14, with a file datestamp of 2021-07-09.
Experiment type: XRAY
Resolution: 2.7 Å
R-factor: N/A
AEROSPACI score: 0.23 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Chitinase 3-like 1 (Cartilage glycoprotein-39), isoform CRA_a
    Species: Homo sapiens [TaxId:9606]
    Gene: CHI3L1, hCG_24326
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d7cj2a1, d7cj2a2
  • Chain 'B':
    Compound: Chitinase 3-like 1 (Cartilage glycoprotein-39), isoform CRA_a
    Species: Homo sapiens [TaxId:9606]
    Gene: CHI3L1, hCG_24326
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d7cj2b1, d7cj2b2
  • Chain 'C':
    Compound: Fab(Heavy chain)
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 7CJ2 (0-221)
    Domains in SCOPe 2.08: d7cj2c_
  • Chain 'D':
    Compound: Fab(Light chain)
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 7CJ2 (0-214)
    Domains in SCOPe 2.08: d7cj2d_
  • Chain 'K':
    Compound: Fab(Heavy chain)
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 7CJ2 (0-221)
    Domains in SCOPe 2.08: d7cj2k_
  • Chain 'L':
    Compound: Fab(Light chain)
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 7CJ2 (0-214)
    Domains in SCOPe 2.08: d7cj2l_
  • Heterogens: BMA, NAG, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >7cj2A (A:)
yklvcyytswsqyregdgscfpdaldrflcthiiysfanisndhidtwewndvtlygmln
tlknrnpnlktllsvggwnfgsqrfskiasntqsrrtfiksvppflrthgfdgldlawly
pgrrdkqhfttlikemkaefikeaqpgkkqlllsaalsagkvtidssydiakisqhldfi
simtydfhgawrgttghhsplfrgqedaspdrfsntdyavgymlrlgapasklvmgiptf
grsftlassetgvgapisgpgipgrftkeagtlayyeicdflrgatvhrilgqqvpyatk
gnqwvgyddqesvkskvqylkdrqlagamvwaldlddfqgsfcgqdlrfpltnaikdala
at

    Sequence, based on observed residues (ATOM records): (download) 
    >7cj2A (A:)
yklvcyytswsqyregdgscfpdaldrflcthiiysfanisndhidtwewndvtlygmln
tlknrnpnlktllsvggwnfgsqrfskiasntqsrrtfiksvppflrthgfdgldlawly
pgrrdkqhfttlikemkaefikeaqpgkkqlllsaalsagkvtidssydiakisqhldfi
simtydfhgawrgttghhsplfrgqedaspdrfsntdyavgymlrlgapasklvmgiptf
grsftlassetgvgapisgpgipgrftkeagtlayyeicdflrgatvhrilgqqvpyatk
gnqwvgyddqesvkskvqylkdrqlagamvwaldlddfqgsfcgqdlrfpltnaikdala
a

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >7cj2B (B:)
yklvcyytswsqyregdgscfpdaldrflcthiiysfanisndhidtwewndvtlygmln
tlknrnpnlktllsvggwnfgsqrfskiasntqsrrtfiksvppflrthgfdgldlawly
pgrrdkqhfttlikemkaefikeaqpgkkqlllsaalsagkvtidssydiakisqhldfi
simtydfhgawrgttghhsplfrgqedaspdrfsntdyavgymlrlgapasklvmgiptf
grsftlassetgvgapisgpgipgrftkeagtlayyeicdflrgatvhrilgqqvpyatk
gnqwvgyddqesvkskvqylkdrqlagamvwaldlddfqgsfcgqdlrfpltnaikdala
at

    Sequence, based on observed residues (ATOM records): (download) 
    >7cj2B (B:)
yklvcyytswsqyregdgscfpdaldrflcthiiysfanisndhidtwewndvtlygmln
tlknrnpnlktllsvggwnfgsqrfskiasntqsrrtfiksvppflrthgfdgldlawly
pgrrdkqhfttlikemkaefikeaqpgkkqlllsaalsagkvtidssydiakisqhldfi
simtydfhgawrgttghhsplfrgqedaspdrfsntdyavgymlrlgapasklvmgiptf
grsftlassetgvgapisgpgipgrftkeagtlayyeicdflrgatvhrilgqqvpyatk
gnqwvgyddqesvkskvqylkdrqlagamvwaldlddfqgsfcgqdlrfpltnaikdala
a

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >7cj2C (C:)
evqlvesggglvqpggslrlscaasgftfsnyamswvrqapgkglewvsgisgsggttyy
adsvkgrftisrdnskntlylqmnslraedtavyycagvgtfdvwgqgtlvtvssastak
gpsvfplapsskstsggtaalgclvkdyfpepvtvswnsgaltsgvhtfpavlqssglys
lssvvtvpssslgtqtyicnvnhkpsntkvdkkvepkscdkt

    Sequence, based on observed residues (ATOM records): (download) 
    >7cj2C (C:)
evqlvesggglvqpggslrlscaasgftfsnyamswvrqapgkglewvsgisgsggttyy
adsvkgrftisrdnskntlylqmnslraedtavyycagvgtfdvwgqgtlvtvssastak
gpsvfplapstaalgclvkdyfpepvtvswnsgaltsgvhtfpavlqssglyslssvvtv
pssslgyicnvnhkpsntkvdkkv

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >7cj2D (D:)
diqmtqspsslsasvgdrvtitcrasqtisswlnwyqqkpgkapklliyaasrlqsgvps
rfsgsgsgtdftltisslqpedfatyycqqsystpltfgqgtkveikastvaapsvfifp
psdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstyslsstl
tlskadyekhkvyacevthqglsspvtksfnrgec

    Sequence, based on observed residues (ATOM records): (download) 
    >7cj2D (D:)
diqmtqspsslsasvgdrvtitcrasqtisswlnwyqqkpgkapklliyaasrlqsgvps
rfsgsgsgtdftltisslqpedfatyycqqsystpltfgqgtkveikastvaapsvfifp
psdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstyslsstl
tlskadyekhkvyacevthqglsspvtksfn

  • Chain 'K':
    Sequence, based on SEQRES records: (download) 
    >7cj2K (K:)
evqlvesggglvqpggslrlscaasgftfsnyamswvrqapgkglewvsgisgsggttyy
adsvkgrftisrdnskntlylqmnslraedtavyycagvgtfdvwgqgtlvtvssastak
gpsvfplapsskstsggtaalgclvkdyfpepvtvswnsgaltsgvhtfpavlqssglys
lssvvtvpssslgtqtyicnvnhkpsntkvdkkvepkscdkt

    Sequence, based on observed residues (ATOM records): (download) 
    >7cj2K (K:)
evqlvesggglvqpggslrlscaasgftfsnyamswvrqapgkglewvsgisgsggttyy
adsvkgrftisrdnskntlylqmnslraedtavyycagvgtfdvwgqgtlvtvssastak
gpsvfplagclvkdyfpepvtvswnsgaltsgvhtfpavlqssglyslssvvivnhkpsn
tkvdkkve

  • Chain 'L':
    Sequence, based on SEQRES records: (download) 
    >7cj2L (L:)
diqmtqspsslsasvgdrvtitcrasqtisswlnwyqqkpgkapklliyaasrlqsgvps
rfsgsgsgtdftltisslqpedfatyycqqsystpltfgqgtkveikastvaapsvfifp
psdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstyslsstl
tlskadyekhkvyacevthqglsspvtksfnrgec

    Sequence, based on observed residues (ATOM records): (download) 
    >7cj2L (L:)
diqmtqspsslsasvgdrvtitcrasqtisswlnwyqqkpgkapklliyaasrlqsgvps
rfsgsgsgtdftltisslqpedfatyycqqsystpltfgqgtkveikastvaapsvfifp
psdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstyslsstl
tlskadyekhkvyacevthqglsspvtk