PDB entry 7chg

View 7chg on RCSB PDB site
Description: the structure of human pregnane x receptor in complex with an src-1 coactivator peptide and a limonoid compound
Deposited on 2020-07-05, released 2021-07-07
The last revision was dated 2021-07-07, with a file datestamp of 2021-07-02.
Experiment type: XRAY
Resolution: 1.93 Å
R-factor: N/A
AEROSPACI score: 0.42 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Nuclear receptor subfamily 1 group I member 2,Nuclear receptor coactivator 1
    Species: Homo sapiens [TaxId:9606]
    Gene: NCOA1, BHLHE74, SRC1
    Database cross-references and differences (RAF-indexed):
    • Uniprot O75469 (1-305)
      • initiating methionine (0)
      • linker (306-311)
    • Uniprot Q15788 (312-336)
  • Chain 'B':
    Compound: Nuclear receptor subfamily 1 group I member 2,Nuclear receptor coactivator 1
    Species: Homo sapiens [TaxId:9606]
    Gene: NCOA1, BHLHE74, SRC1
    Database cross-references and differences (RAF-indexed):
    • Uniprot O75469 (1-305)
      • initiating methionine (0)
      • linker (306-311)
    • Uniprot Q15788 (312-336)
  • Heterogens: G3L, HOH

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >7chgA (A:)
msertgtqplgvqglteeqrmmirelmdaqmktfdttfshfknfrlpgvlssgcelpesl
qapsreeaakwsqvrkdlcslkvslqlrgedgsvwnykppadsggkeifsllphmadmst
ymfkgiisfakvisyfrdlpiedqisllkgaafelcqlrfntvfnaetgtwecgrlsycl
edtaggfqqlllepmlkfhymlkklqlheeeyvlmqaislfspdrpgvlqhrvvdqlqeq
faitlksyiecnrpqpahrflflkimamltelrsinaqhtqrllriqdihpfatplmqel
fgitgssssggtcpsshsslterhkilhrllqegsps

    Sequence, based on observed residues (ATOM records):
    >7chgA (A:)
glteeqrmmirelmdaqmktfdttfshfknfrlpgvreeaakwsqvrkdlcslkvslqlr
gedgsvwnykppadsggkeifsllphmadmstymfkgiisfakvisyfrdlpiedqisll
kgaafelcqlrfntvfnaetgtwecgrlsyclelllepmlkfhymlkklqlheeeyvlmq
aislfspdrpgvlqhrvvdqlqeqfaitlksyiecnrpqpahrflflkimamltelrsin
aqhtqrllriqdihpfatplmqelfgitslterhkilhrllq

  • Chain 'B':
    Sequence, based on SEQRES records:
    >7chgB (B:)
msertgtqplgvqglteeqrmmirelmdaqmktfdttfshfknfrlpgvlssgcelpesl
qapsreeaakwsqvrkdlcslkvslqlrgedgsvwnykppadsggkeifsllphmadmst
ymfkgiisfakvisyfrdlpiedqisllkgaafelcqlrfntvfnaetgtwecgrlsycl
edtaggfqqlllepmlkfhymlkklqlheeeyvlmqaislfspdrpgvlqhrvvdqlqeq
faitlksyiecnrpqpahrflflkimamltelrsinaqhtqrllriqdihpfatplmqel
fgitgssssggtcpsshsslterhkilhrllqegsps

    Sequence, based on observed residues (ATOM records):
    >7chgB (B:)
glteeqrmmirelmdaqmktfdttfshfknfrlpgvlseaakwsqvrkdlcslkvslqlr
gedgsvwnykppadsggkeifsllphmadmstymfkgiisfakvisyfrdlpiedqisll
kgaafelcqlrfntvfnaetgtwecgrlsycleqqlllepmlkfhymlkklqlheeeyvl
mqaislfspdrpgvlqhrvvdqlqeqfaitlksyiecnrpqpahrflflkimamltelrs
inaqhtqrllriqdihpfatplmqelfgitlterhkilhrllq