PDB entry 7cec

View 7cec on RCSB PDB site
Description: structure of alpha6beta1 integrin in complex with laminin-511
Deposited on 2020-06-22, released 2021-06-23
The last revision was dated 2021-07-14, with a file datestamp of 2021-07-09.
Experiment type: EM
Resolution: 3.9 Å
R-factor: N/A
AEROSPACI score: 0.09 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Integrin alpha-6
    Species: Homo sapiens [TaxId:9606]
    Gene: ITGA6
    Database cross-references and differences (RAF-indexed):
    • Uniprot P23229 (0-617)
      • expression tag (618-626)
  • Chain 'B':
    Compound: Integrin beta-1
    Species: Homo sapiens [TaxId:9606]
    Gene: ITGB1, FNRB, MDF2, MSK12
    Database cross-references and differences (RAF-indexed):
    • Uniprot P05556 (0-444)
      • expression tag (445-453)
  • Chain 'C':
    Compound: laminin subunit alpha-5
    Species: Homo sapiens [TaxId:9606]
    Gene: LAMA5, KIAA0533, KIAA1907
    Database cross-references and differences (RAF-indexed):
    • Uniprot O15230 (1-673)
      • expression tag (0)
      • engineered mutation (69)
  • Chain 'D':
    Compound: laminin subunit beta-1
    Species: Homo sapiens [TaxId:9606]
    Gene: LAMB1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P07942 (1-73)
      • expression tag (0)
  • Chain 'E':
    Compound: laminin subunit gamma-1
    Species: Homo sapiens [TaxId:9606]
    Gene: LAMC1, LAMB2
    Database cross-references and differences (RAF-indexed):
    • Uniprot P11047 (1-82)
      • expression tag (0)
      • engineered mutation (58)
  • Chain 'F':
    Compound: ts2/16 vh(s112c)-sarah,ts2/16 vh(s112c)-sarah
    Species: Homo sapiens [TaxId:10090]
    Database cross-references and differences (RAF-indexed):
    • PDB 7CEC (0-120)
    • PDB 7CEC (121-171)
  • Chain 'G':
    Compound: ts2/16 vl-sarah(s37c),ts2/16 vl-sarah(s37c)
    Species: Homo sapiens [TaxId:10090]
    Database cross-references and differences (RAF-indexed):
    • PDB 7CEC (0-112)
    • PDB 7CEC (113-163)
  • Chain 'H':
    Compound: huts-4 vh(s112c)-sarah,huts-4 vh(s112c)-sarah
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 7CEC (0-122)
    • PDB 7CEC (123-173)
  • Chain 'I':
    Compound: huts-4 vl(c87y)-sarah(s37c),huts-4 vl(c87y)-sarah(s37c)
    Species: Homo sapiens [TaxId:10090]
    Database cross-references and differences (RAF-indexed):
    • PDB 7CEC (0-107)
    • PDB 7CEC (108-158)
  • Heterogens: CA, NAG, MN

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >7cecA (A:)
fnldtrednvirkygdpgslfgfslamhwqlqpedkrlllvgapraealplqranrtggl
yscditargpctriefdndadptseskedqwmgvtvqsqgpggkvvtcahryekrqhvnt
kqesrdifgrcyvlsqnlrieddmdggdwsfcdgrlrghekfgscqqgvaatftkdfhyi
vfgapgtynwkgivrveqknntffdmnifedgpyevggetehdeslvpvpansylgfsld
sgkgivskdeitfvsgapranhsgavvllkrdmksahllpehifdgeglassfgydvavv
dlnkdgwqdivigapqyfdrdgevggavyvymnqqgrwnnvkpirlngtkdsmfgiavkn
igdinqdgypdiavgapyddlgkvfiyhgsangintkptqvlkgispyfgysiagnmdld
rnsypdvavgslsdsvtifrsrpviniqktitvtpnridlrqktacgapsgiclqvkscf
eytanpagynpsisivgtleaekerrksglssrvqfrnqgsepkytqeltlkrqkqkvcm
eetlwlqdnirdklrpipitasveiqepssrrrvnslpevlpilnsdepktahidvhflk
egcgddnvcnsnlkleykgslenlyfq

    Sequence, based on observed residues (ATOM records):
    >7cecA (A:)
fnldtrednvirkygdpgslfgfslamhwqlqpedkrlllvgapraealplqranrtggl
yscditargpctriefdndadptseskedqwmgvtvqsqgpggkvvtcahryekrqhvnt
kqesrdifgrcyvlsqnlrieddmdggdwsfcdgrlrghekfgscqqgvaatftkdfhyi
vfgapgtynwkgivrveqdgpyevgpvpansylgfsldsgkgivskdeitfvsgapranh
sgavvllkrdmksahllpehifdgeglassfgydvavvdlnkdgwqdivigapqyfdrdg
evggavyvymnqqgrwnnvkpirlngtkdsmfgiavknigdinqdgypdiavgapyddlg
kvfiyhgsangintkptqvlkgispyfgysiagnmdldrnsypdvavgslsdsvtifrsr
pviniqktitvtpnridlrqktacgapsgiclqvkscfeytanpagynpsisivgtleae
kessrvqfrkytqeltlkrqkqkvcmeetlwlqdnlrpipitasveiqeplpevlpilns
depktahidvhfl

  • Chain 'B':
    Sequence, based on SEQRES records:
    >7cecB (B:)
qtdenrclkanakscgeciqagpncgwctnstflqegmptsarcddlealkkkgcppddi
enprgskdikknknvtnrskgtaeklkpeditqiqpqqlvlrlrsgepqtftlkfkraed
ypidlyylmdlsysmkddlenvkslgtdlmnemrritsdfrigfgsfvektvmpyisttp
aklrnpctseqnctspfsyknvlsltnkgevfnelvgkqrisgnldspeggfdaimqvav
cgsligwrnvtrllvfstdagfhfagdgklggivlpndgqchlennmytmshyydypsia
hlvqklsenniqtifavteefqpvykelknlipksavgtlsanssnviqliidaynslss
evilengklsegvtisyksyckngvngtgengrkcsnisigdevqfeisitsnkcpkkds
dsfkirplgfteevevilqyicecegglenlyfq

    Sequence, based on observed residues (ATOM records):
    >7cecB (B:)
nrclkanakscgeciqagpncgwctnstfltsarcddlealkkkgcppddienprgskdi
kknknvtnlkpeditqiqpqqlvlrlrsgepqtftlkfkraedypidlyylmdlsysmkd
dlenvkslgtdlmnemrritsdfrigfgsfvektvmpyisttpaklrnpctseqnctspf
syknvlsltnkgevfnelvgkqrisgnldspeggfdaimqvavcgsligwrnvtrllvfs
tdagfhfagdgklggivlpndgqchlennmytmshyydypsiahlvqklsenniqtifav
teefqpvykelknlipksavgtlsanssnviqliidaynslssevilengklsegvtisy
ksyckngvngtgengrkcsnisigdevqfeisitsnkcpkkdsdsfkirplgfteevevi
lqyicec

  • Chain 'C':
    Sequence, based on SEQRES records:
    >7cecC (C:)
genverwqgqyeglrgqdlgqavldaghsvstlektlpqllaklsilenrgvhnaslals
asigrvrelcaqargaaskvkvpmkfngrsgvqlrtprdladlaaytalkfylqgpepep
gqgtedrfvmymgsrqatgdymgvslrdkkvhwvyqlgeagpavlsidedigeqfaavsl
drtlqfghmsvtverqmiqetkgdtvapgaegllnlrpddfvfyvggypstftpppllrf
pgyrgciemdtlneevvslynfertfqldtavdrpcarskstgdpwltdgsyldgtgfar
isfdsqisttkrfeqelrlvsysgvlfflkqqsqflclavqegslvllydfgaglkkavp
lqppppltsaskaiqvfllggsrkrvlvrveratvysveqdndleladayylggvppdql
ppslrrlfptggsvrgcvkgikalgkyvdlkrlnttgvsagctadllvgramtfhghgfl
rlalsnvapltgnvysgfgfhsaqdsallyyraspdglcqvslqqgrvslqllrtevktq
agfadgaphyvafysnatgvwlyvddqlqqmkphrgpppelqpqpegpprlllgglpesg
tiynfsgcisnvfvqrllgpqrvfdlqqnlgsvnvstgcapalqaqtpglgprglqatar
kasrrsrqparhpa

    Sequence, based on observed residues (ATOM records):
    >7cecC (C:)
vhnaslalsasigrvrelcaqargaaskvkvpmkfngrsgvqlrtprdladlaaytalkf
ylqgpedrfvmymgsrqatgdymgvslrdkkvhwvyqlgeagpavlsidedigeqfaavs
ldrtlqfghmsvtverqmiqetkgdtvapgaegllnlrpddfvfyvggypstftpppllr
fpgyrgciemdtlneevvslynfertfqldtavdrpcarskstgdpwltdgsyldgtgfa
risfdsqisttkrfeqelrlvsysgvlfflkqqsqflclavqegslvllydfgaglkkav
plqppppltsaskaiqvfllggsrkrvlvrveratvysveqdndleladayylggvppdq
lppslrrlfptggsvrgcvkgikalgkyvdlkrlnttgvsagctadllvgramtfhghgf
lrlalsnvapltgnvysgfgfhsaqdsallyyraspdglcqvslqqgrvslqllrtevkt
qagfadgaphyvafysnatgvwlyvddqlqqmkphrgppegpprlllgglpesgtiynfs
gcisnvfvqrllgpqrvfdlqqnlgsvnvstgca

  • Chain 'D':
    Sequence, based on SEQRES records:
    >7cecD (D:)
gdarrkaemlqneaktllaqansklqllkdlerkyednqryledkaqelarlegevrsll
kdisqkvavystcl

    Sequence, based on observed residues (ATOM records):
    >7cecD (D:)
lkdlerkyednqryledkaqelarlegevrsllkdisqkvavystcl

  • Chain 'E':
    Sequence, based on SEQRES records:
    >7cecE (E:)
gdtvdlnklneiegtlnkakdemkvsdldrkvsdleneakkqeaaimdynrdieeimkci
rnledirktlpsgcfntpsiekp

    Sequence, based on observed residues (ATOM records):
    >7cecE (E:)
kkqeaaimdynrdieeimkcirnledirktlpsgcfntpsiekp

  • Chain 'F':
    Sequence, based on SEQRES records:
    >7cecF (F:)
mdvklvesggglvkpggslklscaasgftfssytmswvrqtpekrlewvatissggsyty
ypdsvkgrftisrdkakntlylqmgslksedtamyyctrigydedyamdhwgqgtsvtvc
sgsdyeflkswtvedlqkrllaldpmmeqeieeirqkyqskrqpildaieak

    Sequence, based on observed residues (ATOM records):
    >7cecF (F:)
dvklvesggglvkpggslklscaasgftfssytmswvrqtpekrlewvatissggsytyy
pdsvkgrftisrdkakntlylqmgslksedtamyyctrigydedyamdhwgqgtsvtvcs
gsdyeflkswtvedlqkrllaldpmmeqeieeirqkyqskrqpildaieak

  • Chain 'G':
    Sequence, based on SEQRES records:
    >7cecG (G:)
gshmqivvtqrpttmaaspgdkiiitcsvssiissnylhwysqkpgfspklliyrtsnla
sgvpprfsgsgsgtsysltigtmeaedvatyycqqgsdipltfgdgtkldlkrgsdyefl
kswtvedlqkrllaldpmmeqeieeirqkyqckrqpildaieak

    Sequence, based on observed residues (ATOM records):
    >7cecG (G:)
qivvtqrpttmaaspgdkiiitcsvssiissnylhwysqkpgfspklliyrtsnlasgvp
prfsgsgsgtsysltigtmeaedvatyycqqgsdipltfgdgtkldlkrgsdyeflkswt
vedlqkrllaldpmmeqeieeirqkyqckrqpildaieak

  • Chain 'H':
    Sequence, based on SEQRES records:
    >7cecH (H:)
mqvtlkesgpgilqpsqtlsltcsfsgfslstsgmgvswirqpsgkglewlahiywdddk
ryhpslksrltiskdtssnqvflkitsvdtadtatyycarsiydgyydyfdvwgagttvt
vcsgsdyeflkswtvedlqkrllaldpmmeqeieeirqkyqskrqpildaieak

    Sequence, based on observed residues (ATOM records):
    >7cecH (H:)
mqvtlkesgpgilqpsqtlsltcsfsgfslstsgmgvswirqpsgkglewlahiywdddk
ryhpslksrltiskdtssnqvflkitsvdtadtatyycarsiydgyydyfdvwgagttvt
vc

  • Chain 'I':
    Sequence, based on SEQRES records:
    >7cecI (I:)
mqivlsqspailsaspgekvtmtcratssvtymhwyqqkpgsspkpwiyatsnlasgvpa
rfsgsgsgtsysltisrveaadaatyycqqwtsnpptfgggtkleikrgsdyeflkswtv
edlqkrllaldpmmeqeieeirqkyqckrqpildaieak

    Sequence, based on observed residues (ATOM records):
    >7cecI (I:)
qivlsqspailsaspgekvtmtcratssvtymhwyqqkpgsspkpwiyatsnlasgvpar
fsgsgsgtsysltisrveaadaatyycqqwtsnpptfgggtkleiklqkrllaldpmmeq
eieeirqkyqckrqpildai