PDB entry 7ce3

View 7ce3 on RCSB PDB site
Description: crystal structure of human idh3 holoenzyme in apo form.
Deposited on 2020-06-21, released 2021-01-06
The last revision was dated 2021-01-06, with a file datestamp of 2021-01-01.
Experiment type: XRAY
Resolution: 3.47 Å
R-factor: N/A
AEROSPACI score: 0.1 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial
    Species: Homo sapiens [TaxId:9606]
    Gene: IDH3A
    Database cross-references and differences (RAF-indexed):
  • Chain 'B':
    Compound: Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial
    Species: Homo sapiens [TaxId:9606]
    Gene: IDH3G
    Database cross-references and differences (RAF-indexed):
  • Chain 'C':
    Compound: Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial
    Species: Homo sapiens [TaxId:9606]
    Gene: IDH3A
    Database cross-references and differences (RAF-indexed):
  • Chain 'D':
    Compound: Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial
    Species: Homo sapiens [TaxId:9606]
    Gene: IDH3B
    Database cross-references and differences (RAF-indexed):
    • Uniprot O43837 (Start-342)
      • expression tag (343-357)

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >7ce3A (A:)
magpawiskvsrllgafhnpkqvtrgftggvqtvtlipgdgigpeisaavmkifdaakap
iqweernvtaiqgpggkwmipseakesmdknkmglkgplktpiaaghpsmnlllrktfdl
yanvrpcvsiegyktpytdvnivtirentegeysgiehvivdgvvqsiklitegaskria
efafeyarnnhrsnvtavhkanimrmsdglflqkcrevaesckdikfnemyldtvclnmv
qdpsqfdvlvmpnlygdilsdlcagligglgvtpsgnigangvaifesvhgtapdiagkd
manptalllsavmmlrhmglfdhaarieaacfatikdgksltkdlggnakcsdfteeicr
rvkdld

    Sequence, based on observed residues (ATOM records):
    >7ce3A (A:)
gvqtvtlipgdgigpeisaavmkifdaakapiqweernvtaiqkwmipseakesmdknkm
glkgplkthpsmnlllrktfdlyanvrpcvsiegyktpytdvnivtirentegeysgieh
vivdgvvqsiklitegaskriaefafeyarnnhrsnvtavhkanimrmsdglflqkcrev
aesckdikfnemyldtvclnmvqdpsqfdvlvmpnlygdilsdlcagligglgvtpsgni
gangvaifesvhgtapdiagkdmanptalllsavmmlrhmglfdhaarieaacfatikdg
ksltkdlggnakcsdfteeicrrvkd

  • Chain 'B':
    Sequence, based on SEQRES records:
    >7ce3B (B:)
mgsfseqtippsakyggrhtvtmipgdgigpelmlhvksvfrhacvpvdfeevhvssnad
eedirnaimairrnrvalkgnietnhnlppshksrnnilrtsldlyanvihckslpgvvt
rhkdidilivrentegeysslehesvagvveslkiitkakslriaeyafklaqesgrkkv
tavhkanimklgdglflqccrevaarypqitfenmivdnttmqlvsrpqqfdvmvmpnly
gnivnnvcaglvggpglvaganyghvyavfetatrntgksianknianptatllascmml
dhlklhsyatsirkavlasmdnenmhtpdiggqgttseaiqdvirhirvingravea

    Sequence, based on observed residues (ATOM records):
    >7ce3B (B:)
tippsakyggrhtvtmipgdgigpelmlhvksvfrhacvpvdfeevhvssnadeedirna
imairrnrvalkgnietnlppshksrnnilrtsldlyanvihckslpgvvtrhkdidili
vrentegeysslehesvagvveslkiitkakslriaeyafklaqesgrkkvtavhkanim
klgdglflqccrevaarypqitfenmivdnttmqlvsrpqqfdvmvmpnlygnivnnvca
glvggpglvaganyghvyavfetatrntgksianknianptatllascmmldhlklhsya
tsirkavlasmdnenmhtpdiggqgttseaiqdvirhirvingra

  • Chain 'C':
    Sequence, based on SEQRES records:
    >7ce3C (C:)
magpawiskvsrllgafhnpkqvtrgftggvqtvtlipgdgigpeisaavmkifdaakap
iqweernvtaiqgpggkwmipseakesmdknkmglkgplktpiaaghpsmnlllrktfdl
yanvrpcvsiegyktpytdvnivtirentegeysgiehvivdgvvqsiklitegaskria
efafeyarnnhrsnvtavhkanimrmsdglflqkcrevaesckdikfnemyldtvclnmv
qdpsqfdvlvmpnlygdilsdlcagligglgvtpsgnigangvaifesvhgtapdiagkd
manptalllsavmmlrhmglfdhaarieaacfatikdgksltkdlggnakcsdfteeicr
rvkdld

    Sequence, based on observed residues (ATOM records):
    >7ce3C (C:)
gvqtvtlipgdgigpeisaavmkifdaakapiqweernvtaiqgpggkwmipseakesmd
knkmglkgplktpiaaghpsmnlllrktfdlyanvrpcvsiegyktpytdvnivtirent
egeysgiehvivdgvvqsiklitegaskriaefafeyarnnhrsnvtavhkanimrmsdg
lflqkcrevaesckdikfnemyldtvclnmvqdpsqfdvlvmpnlygdilsdlcagligg
lgvtpsgnigangvaifesvhgtapdiagkdmanptalllsavmmlrhmglfdhaariea
acfatikdgksltkdlggnakcsdfteeicrrvkd

  • Chain 'D':
    Sequence, based on SEQRES records:
    >7ce3D (D:)
mgsasrsqaedvrvegsfpvtmlpgdgvgpelmhavkevfkaaavpvefqehhlsevqnm
aseekleqvlssmkenkvaiigkihtpmeykgelasydmrlrrkldlfanvvhvkslpgy
mtrhnnldlviireqtegeysslehesargvieclkivtraksqriakfafdyatkkgrg
kvtavhkanimklgdglflqcceevaelypkikfetmiidnccmqlvqnpyqfdvlvmpn
lygniidnlaaglvggagvvpgesysaeyavfetgarhpfaqavgrnianptamllsasn
mlrhlnleyhssmiadavkkvikvgkvrtsdmggyatchdfteeicrrvkdldenlyfq

    Sequence, based on observed residues (ATOM records):
    >7ce3D (D:)
rvegsfpvtmlpgdgvgpelmhavkevfkaaavpvefqehhlmaseekleqvlssmkenk
vaiigkihtsydmrlrrkldlfanvvhvkslpgymtrhnnldlviireqtegeysslehe
sargvieclkivtraksqriakfafdyatkkgrgkvtavhkanimklgdglflqcceeva
elypkikfetmiidnccmqlvqnpyqfdvlvmpnlygniidnlaaglvggagvvpgesys
aeyavfetgarhpfaqavgrnianptamllsasnmlrhlnleyhssmiadavkkvikvgk
vrtsdmggyatchdfteeicrrvkdldenlyf