PDB entry 7cca

View 7cca on RCSB PDB site
Description: Crystal structure of White Spot Syndrome Virus Thymidylate Synthase - ternary complex with Methotrexate and dUMP
Class: transferase
Keywords: Thymidylate Synthase, BIOSYNTHETIC PROTEIN, TRANSFERASE
Deposited on 2020-06-16, released 2020-11-25
The last revision prior to the SCOPe 2.08 freeze date was dated 2021-01-27, with a file datestamp of 2021-01-22.
Experiment type: XRAY
Resolution: 2.75 Å
R-factor: N/A
AEROSPACI score: 0.24 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Thymidylate synthase
    Species: White spot syndrome virus (isolate Shrimp/China/Tongan/1996) [TaxId:654913]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d7ccaa_
  • Chain 'B':
    Compound: Thymidylate synthase
    Species: White spot syndrome virus (isolate Shrimp/China/Tongan/1996) [TaxId:654913]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d7ccab_
  • Heterogens: MTX, UMP, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >7ccaA (A:)
megehqylnlvreilergvkkddrtgtgtlsifgpqmrfslrddtipvlttkkifwrgvv
eellwfirgntdakelakkkihiwnangsrefldsrglydraegdlgpvygfqwrhfgae
ydtcssdytgkgidqlanilktlrenpddrrmimtawnpmdlhlmalppchmtaqfyvan
gelscqlyqrsgdvglgvpfniasysllthlmasmvglkpgefiltlgdahiynthievl
kkqlcrvprpfpklrilmapekiedftidmfylegyqphsgnlqmkmavlehhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >7ccaA (A:)
megehqylnlvreilergvkkddrtgtgtlsifgpqmrfslrddtipvlttkkifwrgvv
eellwfirgntdakelakkkihiwnangsrefldsrglydraegdlgpvygfqwrhfgae
ydtcssdytgkgidqlanilktlrenpddrrmimtawnpmdlhlmalppchmtaqfyvan
gelscqlyqrsgdvglgvpfniasysllthlmasmvglkpgefiltlgdahiynthievl
kkqlcrvprpfpklrilmapekiedftidmfylegyqphsgnlqmkmav

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >7ccaB (B:)
megehqylnlvreilergvkkddrtgtgtlsifgpqmrfslrddtipvlttkkifwrgvv
eellwfirgntdakelakkkihiwnangsrefldsrglydraegdlgpvygfqwrhfgae
ydtcssdytgkgidqlanilktlrenpddrrmimtawnpmdlhlmalppchmtaqfyvan
gelscqlyqrsgdvglgvpfniasysllthlmasmvglkpgefiltlgdahiynthievl
kkqlcrvprpfpklrilmapekiedftidmfylegyqphsgnlqmkmavlehhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >7ccaB (B:)
megehqylnlvreilergvkkddrtgtgtlsifgpqmrfslrddtipvlttkkifwrgvv
eellwfirgntdakelakkkihiwnangsrefldsrglydraegdlgpvygfqwrhfgae
ydtcssdytgkgidqlanilktlrenpddrrmimtawnpmdlhlmalppchmtaqfyvan
gelscqlyqrsgdvglgvpfniasysllthlmasmvglkpgefiltlgdahiynthievl
kkqlcrvprpfpklrilmapekiedftidmfylegyqphsgnlqmkm