PDB entry 7cai

View 7cai on RCSB PDB site
Description: sars-cov-2 s trimer with two rbds in the open state and complexed with two h014 fab
Deposited on 2020-06-08, released 2020-09-23
The last revision was dated 2020-09-30, with a file datestamp of 2020-09-25.
Experiment type: EM
Resolution: 3.49 Å
R-factor: N/A
AEROSPACI score: 0.15 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Spike glycoprotein
    Species: Severe acute respiratory syndrome coronavirus 2 [TaxId:2697049]
    Gene: S, 2
    Database cross-references and differences (RAF-indexed):
    • Uniprot P0DTC2
      • engineered mutation (985-986)
  • Chain 'B':
    Compound: Spike glycoprotein
    Species: Severe acute respiratory syndrome coronavirus 2 [TaxId:2697049]
    Gene: S, 2
    Database cross-references and differences (RAF-indexed):
    • Uniprot P0DTC2
      • engineered mutation (985-986)
  • Chain 'C':
    Compound: Spike glycoprotein
    Species: Severe acute respiratory syndrome coronavirus 2 [TaxId:2697049]
    Gene: S, 2
    Database cross-references and differences (RAF-indexed):
    • Uniprot P0DTC2
      • engineered mutation (985-986)
  • Chain 'D':
    Compound: Light chain of H014 Fab
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 7CAI (0-End)
  • Chain 'E':
    Compound: Heavy chain of H014 Fab
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 7CAI
  • Chain 'F':
    Compound: Light chain of H014 Fab
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 7CAI (0-End)
  • Chain 'G':
    Compound: Heavy chain of H014 Fab
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 7CAI
  • Heterogens: NAG

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >7caiA (A:)
mfvflvllplvssqcvnlttrtqlppaytnsftrgvyypdkvfrssvlhstqdlflpffs
nvtwfhaihvsgtngtkrfdnpvlpfndgvyfasteksniirgwifgttldsktqslliv
nnatnvvikvcefqfcndpflgvyyhknnkswmesefrvyssannctfeyvsqpflmdle
gkqgnfknlrefvfknidgyfkiyskhtpinlvrdlpqgfsaleplvdlpiginitrfqt
llalhrsyltpgdsssgwtagaaayyvgylqprtfllkynengtitdavdcaldplsetk
ctlksftvekgiyqtsnfrvqptesivrfpnitnlcpfgevfnatrfasvyawnrkrisn
cvadysvlynsasfstfkcygvsptklndlcftnvyadsfvirgdevrqiapgqtgkiad
ynyklpddftgcviawnsnnldskvggnynylyrlfrksnlkpferdisteiyqagstpc
ngvegfncyfplqsygfqptngvgyqpyrvvvlsfellhapatvcgpkkstnlvknkcvn
fnfngltgtgvltesnkkflpfqqfgrdiadttdavrdpqtleilditpcsfggvsvitp
gtntsnqvavlyqdvnctevpvaihadqltptwrvystgsnvfqtragcligaehvnnsy
ecdipigagicasyqtqtnspgsassvasqsiiaytmslgaensvaysnnsiaiptnfti
svtteilpvsmtktsvdctmyicgdstecsnlllqygsfctqlnraltgiaveqdkntqe
vfaqvkqiyktppikdfggfnfsqilpdpskpskrsfiedllfnkvtladagfimqygdc
lgdmayrdlicaqkfngltvlpplltdemiaqytsallagtitsgwtfgagaalqipfam
qmayrfngigvtqnvlyenqklianqfnsaigkiqdslsstasalgklqdvvnqnaqaln
tlvkqlssnfgaissvlndilsrldppeaevqidrlitgrlqslqtyvtqqliraaeira
sanlaatkmsecvlgqskrvdfcgkgyhlmsfpqsaphgvvflhvtyvpaqeknfttapa
ichdgkahfpregvfvsngthwfvtqrnfyepqiittdntfvsgncdvvigivnntvydp
lqpeldsfkeeldkyfknhtspdvdlgdisginasvvniqkeidrlnevaknlneslidl
qelgkyeq

    Sequence, based on observed residues (ATOM records):
    >7caiA (A:)
ppaytnsftrgvyypdkvfrssvlhstqdlflpffsnvtwfhaihdnpvlpfndgvyfas
teksniirgwifgttldsktqsllivnnatnvvikvcefqfcndpflgvyyhknnkswme
sefrvyssannctfeyvsfknlrefvfknidgyfkiyskhtpinlvrdlpqgfsaleplv
dlpiginitrfqtllalhaayyvgylqprtfllkynengtitdavdcaldplsetkctlk
sftvekgiyqtsnfrvqptesivrfpnitnlcpfgevfnatrfasvyawnrkrisncvad
ysvlynsasfstfkcygvsptklndlcftnvyadsfvirgdevrqiapgqtgkiadynyk
lpddftgcviawnsnnldskgnynylyrlfrksnlkpferdisteiyqagstpcngvegf
ncyfplqsygfqptngvgyqpyrvvvlsfellhapatvcgpkkstnlvknkcvnfnfngl
tgtgvltesnkkflpfqqfgrdiadttdavrdpqtleilditpcsfggvsvitpgtntsn
qvavlyqdvnctevnvfqtragcligaehvnnsyecdipigagicasyqtsqsiiaytms
lgaensvaysnnsiaiptnftisvtteilpvsmtktsvdctmyicgdstecsnlllqygs
fctqlnraltgiaveqdkntqevfaqvkqiyktppikdfggfnfsqilpdpskpskrsfi
edllfnkvtkfngltvlpplltdemiaqytsallagtitsgwtfgagaalqipfamqmay
rfngigvtqnvlyenqklianqfnsaigkiqdslsstasalgklqdvvnqnaqalntlvk
qlssnfgaissvlndilsrldppeaevqidrlitgrlqslqtyvtqqliraaeirasanl
aatkmsecvlgqskrvdfcgkgyhlmsfpqsaphgvvflhvtyvpaqeknfttapaichd
gkahfpregvfvsngthwfvtqrnfyepqiittdntfvsgncdvvigivnntvydplqpe
lds

  • Chain 'B':
    Sequence, based on SEQRES records:
    >7caiB (B:)
mfvflvllplvssqcvnlttrtqlppaytnsftrgvyypdkvfrssvlhstqdlflpffs
nvtwfhaihvsgtngtkrfdnpvlpfndgvyfasteksniirgwifgttldsktqslliv
nnatnvvikvcefqfcndpflgvyyhknnkswmesefrvyssannctfeyvsqpflmdle
gkqgnfknlrefvfknidgyfkiyskhtpinlvrdlpqgfsaleplvdlpiginitrfqt
llalhrsyltpgdsssgwtagaaayyvgylqprtfllkynengtitdavdcaldplsetk
ctlksftvekgiyqtsnfrvqptesivrfpnitnlcpfgevfnatrfasvyawnrkrisn
cvadysvlynsasfstfkcygvsptklndlcftnvyadsfvirgdevrqiapgqtgkiad
ynyklpddftgcviawnsnnldskvggnynylyrlfrksnlkpferdisteiyqagstpc
ngvegfncyfplqsygfqptngvgyqpyrvvvlsfellhapatvcgpkkstnlvknkcvn
fnfngltgtgvltesnkkflpfqqfgrdiadttdavrdpqtleilditpcsfggvsvitp
gtntsnqvavlyqdvnctevpvaihadqltptwrvystgsnvfqtragcligaehvnnsy
ecdipigagicasyqtqtnspgsassvasqsiiaytmslgaensvaysnnsiaiptnfti
svtteilpvsmtktsvdctmyicgdstecsnlllqygsfctqlnraltgiaveqdkntqe
vfaqvkqiyktppikdfggfnfsqilpdpskpskrsfiedllfnkvtladagfimqygdc
lgdmayrdlicaqkfngltvlpplltdemiaqytsallagtitsgwtfgagaalqipfam
qmayrfngigvtqnvlyenqklianqfnsaigkiqdslsstasalgklqdvvnqnaqaln
tlvkqlssnfgaissvlndilsrldppeaevqidrlitgrlqslqtyvtqqliraaeira
sanlaatkmsecvlgqskrvdfcgkgyhlmsfpqsaphgvvflhvtyvpaqeknfttapa
ichdgkahfpregvfvsngthwfvtqrnfyepqiittdntfvsgncdvvigivnntvydp
lqpeldsfkeeldkyfknhtspdvdlgdisginasvvniqkeidrlnevaknlneslidl
qelgkyeq

    Sequence, based on observed residues (ATOM records):
    >7caiB (B:)
ppaytnsftrgvyypdkvfrssvlhstqdlflpffsnvtwfhaihdnpvlpfndgvyfas
teksniirgwifgttldsktqsllivnnatnvvikvcefqfcndpflgvyyhknnkswme
sefrvyssannctfeyvsfknlrefvfknidgyfkiyskhtpinlvrdlpqgfsaleplv
dlpiginitrfqtllalhaayyvgylqprtfllkynengtitdavdcaldplsetkctlk
sftvekgiyqtsnfrvqptesivrfpnitnlcpfgevfnatrfasvyawnrkrisncvad
ysvlynsasfstfkcygvsptklndlcftnvyadsfvirgdevrqiapgqtgkiadynyk
lpddftgcviawnsnnldskgnynylyrlfrksnlkpferdisteiyqagstpcngvegf
ncyfplqsygfqptngvgyqpyrvvvlsfellhapatvcgpkkstnlvknkcvnfnfngl
tgtgvltesnkkflpfqqfgrdiadttdavrdpqtleilditpcsfggvsvitpgtntsn
qvavlyqdvnctevnvfqtragcligaehvnnsyecdipigagicasyqtsqsiiaytms
lgaensvaysnnsiaiptnftisvtteilpvsmtktsvdctmyicgdstecsnlllqygs
fctqlnraltgiaveqdkntqevfaqvkqiyktppikdfggfnfsqilpdpskpskrsfi
edllfnkvtkfngltvlpplltdemiaqytsallagtitsgwtfgagaalqipfamqmay
rfngigvtqnvlyenqklianqfnsaigkiqdslsstasalgklqdvvnqnaqalntlvk
qlssnfgaissvlndilsrldppeaevqidrlitgrlqslqtyvtqqliraaeirasanl
aatkmsecvlgqskrvdfcgkgyhlmsfpqsaphgvvflhvtyvpaqeknfttapaichd
gkahfpregvfvsngthwfvtqrnfyepqiittdntfvsgncdvvigivnntvydplqpe
lds

  • Chain 'C':
    Sequence, based on SEQRES records:
    >7caiC (C:)
mfvflvllplvssqcvnlttrtqlppaytnsftrgvyypdkvfrssvlhstqdlflpffs
nvtwfhaihvsgtngtkrfdnpvlpfndgvyfasteksniirgwifgttldsktqslliv
nnatnvvikvcefqfcndpflgvyyhknnkswmesefrvyssannctfeyvsqpflmdle
gkqgnfknlrefvfknidgyfkiyskhtpinlvrdlpqgfsaleplvdlpiginitrfqt
llalhrsyltpgdsssgwtagaaayyvgylqprtfllkynengtitdavdcaldplsetk
ctlksftvekgiyqtsnfrvqptesivrfpnitnlcpfgevfnatrfasvyawnrkrisn
cvadysvlynsasfstfkcygvsptklndlcftnvyadsfvirgdevrqiapgqtgkiad
ynyklpddftgcviawnsnnldskvggnynylyrlfrksnlkpferdisteiyqagstpc
ngvegfncyfplqsygfqptngvgyqpyrvvvlsfellhapatvcgpkkstnlvknkcvn
fnfngltgtgvltesnkkflpfqqfgrdiadttdavrdpqtleilditpcsfggvsvitp
gtntsnqvavlyqdvnctevpvaihadqltptwrvystgsnvfqtragcligaehvnnsy
ecdipigagicasyqtqtnspgsassvasqsiiaytmslgaensvaysnnsiaiptnfti
svtteilpvsmtktsvdctmyicgdstecsnlllqygsfctqlnraltgiaveqdkntqe
vfaqvkqiyktppikdfggfnfsqilpdpskpskrsfiedllfnkvtladagfimqygdc
lgdmayrdlicaqkfngltvlpplltdemiaqytsallagtitsgwtfgagaalqipfam
qmayrfngigvtqnvlyenqklianqfnsaigkiqdslsstasalgklqdvvnqnaqaln
tlvkqlssnfgaissvlndilsrldppeaevqidrlitgrlqslqtyvtqqliraaeira
sanlaatkmsecvlgqskrvdfcgkgyhlmsfpqsaphgvvflhvtyvpaqeknfttapa
ichdgkahfpregvfvsngthwfvtqrnfyepqiittdntfvsgncdvvigivnntvydp
lqpeldsfkeeldkyfknhtspdvdlgdisginasvvniqkeidrlnevaknlneslidl
qelgkyeq

    Sequence, based on observed residues (ATOM records):
    >7caiC (C:)
ppaytnsftrgvyypdkvfrssvlhstqdlflpffsnvtwfhaihdnpvlpfndgvyfas
teksniirgwifgttldsktqsllivnnatnvvikvcefqfcndpflgvyyhknnkswme
sefrvyssannctfeyvsfknlrefvfknidgyfkiyskhtpinlvrdlpqgfsaleplv
dlpiginitrfqtllalhaayyvgylqprtfllkynengtitdavdcaldplsetkctlk
sftvekgiyqtsnfrvqptesivrfpnitnlcpfgevfnatrfasvyawnrkrisncvad
ysvlynsasfstfkcygvsptklndlcftnvyadsfvirgdevrqiapgqtgkiadynyk
lpddftgcviawnsnnldskgnynylyrlfrksnlkpferdisteiyqagstpcngvegf
ncyfplqsygfqptngvgyqpyrvvvlsfellhapatvcgpkkstnlvknkcvnfnfngl
tgtgvltesnkkflpfqqfgrdiadttdavrdpqtleilditpcsfggvsvitpgtntsn
qvavlyqdvnctevnvfqtragcligaehvnnsyecdipigagicasyqtsqsiiaytms
lgaensvaysnnsiaiptnftisvtteilpvsmtktsvdctmyicgdstecsnlllqygs
fctqlnraltgiaveqdkntqevfaqvkqiyktppikdfggfnfsqilpdpskpskrsfi
edllfnkvtkfngltvlpplltdemiaqytsallagtitsgwtfgagaalqipfamqmay
rfngigvtqnvlyenqklianqfnsaigkiqdslsstasalgklqdvvnqnaqalntlvk
qlssnfgaissvlndilsrldppeaevqidrlitgrlqslqtyvtqqliraaeirasanl
aatkmsecvlgqskrvdfcgkgyhlmsfpqsaphgvvflhvtyvpaqeknfttapaichd
gkahfpregvfvsngthwfvtqrnfyepqiittdntfvsgncdvvigivnntvydplqpe
lds

  • Chain 'D':
    Sequence, based on SEQRES records:
    >7caiD (D:)
ivltqspfqsvspkekvtitcrasqsissnlhwyqqkpdqspkllikyasqsisgipsrf
sgsgsgtdftltinsleaedfgiyfcqqtnfwpyifgqgtkleilkrtvaapsvfifpps
deqlksgtasvvcllnnfypreakvqwkvdnalqsgnsesvteqdskdstyslsstltls
kadyekhkvyacevthqglsstksfnrgec

    Sequence, based on observed residues (ATOM records):
    >7caiD (D:)
ivltqspfqsvspkekvtitcrasqsissnlhwyqqkpdqspkllikyasqsisgipsrf
sgsgsgtdftltinsleaedfgiyfcqqtnfwpyifgqgtkleilkrtvaapsvfifpps
deqlksgtasvvcllnnfypreakvqwkvdnalqsgnsesvteqdskdstyslsstltls
kadyekhkvyacevthqglsstksfnr

  • Chain 'E':
    Sequence, based on SEQRES records:
    >7caiE (E:)
evqlvqsgaevkkpgatvkisckvsgysfsnyyihwvkqapgkslewigyidpfnggtsd
nlkfkgaatltadtstdtaymelsslrsedtavyycarseydpyyvmdywgqgttvtvss
astkgpsvfplapsskstsggtaalgclvkdyfpepvtvswnsgaltsgvhtfpavlqss
glyslssvvtvpssslgtqtyicnvnhkpsntkvdkkvepksc

    Sequence, based on observed residues (ATOM records):
    >7caiE (E:)
vqlvqsgaevkkpgatvkisckvsgysfsnyyihwvkqapgkslewigyidpfnggtsdn
lkfkgaatltadtstdtaymelsslrsedtavyycarseydpyyvmdywgqgttvtvssa
stkgpsvfplapsggtaalgclvkdyfpepvtvswnsgaltsgvhtfpavlqssglysls
svvtvpssslgtqtyicnvnhkpsntkvdkkvep

  • Chain 'F':
    Sequence, based on SEQRES records:
    >7caiF (F:)
ivltqspfqsvspkekvtitcrasqsissnlhwyqqkpdqspkllikyasqsisgipsrf
sgsgsgtdftltinsleaedfgiyfcqqtnfwpyifgqgtkleilkrtvaapsvfifpps
deqlksgtasvvcllnnfypreakvqwkvdnalqsgnsesvteqdskdstyslsstltls
kadyekhkvyacevthqglsstksfnrgec

    Sequence, based on observed residues (ATOM records):
    >7caiF (F:)
ivltqspfqsvspkekvtitcrasqsissnlhwyqqkpdqspkllikyasqsisgipsrf
sgsgsgtdftltinsleaedfgiyfcqqtnfwpyifgqgtkleilkrtvaapsvfifpps
deqlksgtasvvcllnnfypreakvqwkvdnalqsgnsesvteqdskdstyslsstltls
kadyekhkvyacevthqglsstksfnr

  • Chain 'G':
    Sequence, based on SEQRES records:
    >7caiG (G:)
evqlvqsgaevkkpgatvkisckvsgysfsnyyihwvkqapgkslewigyidpfnggtsd
nlkfkgaatltadtstdtaymelsslrsedtavyycarseydpyyvmdywgqgttvtvss
astkgpsvfplapsskstsggtaalgclvkdyfpepvtvswnsgaltsgvhtfpavlqss
glyslssvvtvpssslgtqtyicnvnhkpsntkvdkkvepksc

    Sequence, based on observed residues (ATOM records):
    >7caiG (G:)
vqlvqsgaevkkpgatvkisckvsgysfsnyyihwvkqapgkslewigyidpfnggtsdn
lkfkgaatltadtstdtaymelsslrsedtavyycarseydpyyvmdywgqgttvtvssa
stkgpsvfplapsggtaalgclvkdyfpepvtvswnsgaltsgvhtfpavlqssglysls
svvtvpssslgtqtyicnvnhkpsntkvdkkvep