PDB entry 7c5d

View 7c5d on RCSB PDB site
Description: Crystal structure of TRF2 TRFH domain in complex with a MCPH1 peptide
Class: protein binding
Keywords: Telomere, shelterin complex, TRF2, MCPH1, DNA repair, PROTEIN BINDING
Deposited on 2020-05-19, released 2020-10-21
The last revision prior to the SCOPe 2.08 freeze date was dated 2020-12-02, with a file datestamp of 2020-11-27.
Experiment type: XRAY
Resolution: 2.15 Å
R-factor: N/A
AEROSPACI score: 0.35 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Telomeric repeat-binding factor 2
    Species: Homo sapiens [TaxId:9606]
    Gene: TRF2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d7c5da_
  • Chain 'B':
    Compound: Telomeric repeat-binding factor 2
    Species: Homo sapiens [TaxId:9606]
    Gene: TRF2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d7c5db_
  • Chain 'C':
    Compound: Microcephalin
    Species: Homo sapiens [TaxId:9606]
    Gene: MCPH1
    Database cross-references and differences (RAF-indexed):
  • Chain 'D':
    Compound: Microcephalin
    Species: Homo sapiens [TaxId:9606]
    Gene: MCPH1
    Database cross-references and differences (RAF-indexed):
  • Heterogens: GOL, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >7c5dA (A:)
gagearleeavnrwvlkfyfhealrafrgsrygdfrqirdimqallvrplgkehtvsrll
rvmqclsrieegenldcsfdmeaeltplesainvlemikteftlteavvessrklvkeaa
viiciknkefekaskilkkhmskdpttqklrndllniireknlahpviqnfsyetfqqkm
lrfleshlddaepylltmakkalk

    Sequence, based on observed residues (ATOM records): (download) 
    >7c5dA (A:)
rleeavnrwvlkfyfhealrafrgsrygdfrqirdimqallvrplgkehtvsrllrvmqc
lsrieegenldcsfdmltplesainvlemikteftlteavvessrklvkeaaviiciknk
efekaskilkkhmskdttqklrndllniireknlahpviqnfsyetfqqkmlrfleshld
daepylltmakkal

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >7c5dB (B:)
gagearleeavnrwvlkfyfhealrafrgsrygdfrqirdimqallvrplgkehtvsrll
rvmqclsrieegenldcsfdmeaeltplesainvlemikteftlteavvessrklvkeaa
viiciknkefekaskilkkhmskdpttqklrndllniireknlahpviqnfsyetfqqkm
lrfleshlddaepylltmakkalk

    Sequence, based on observed residues (ATOM records): (download) 
    >7c5dB (B:)
gagearleeavnrwvlkfyfhealrafrgsrygdfrqirdimqallvrplgkehtvsrll
rvmqclsrieegenldcsfdmeaeltplesainvlemikteftlteavvessrklvkeaa
viiciknkefekaskilkkhmpttqklrndllniireknlahpviqnfsyetfqqkmlrf
leshlddaepylltmakka

  • Chain 'C':
    No sequence available.

  • Chain 'D':
    No sequence available.