PDB entry 7c3g

View 7c3g on RCSB PDB site
Description: Crystal structure of human ALK2 kinase domain with R206H mutation in complex with a bicyclic pyrazole inhibitor RK-73134
Class: signaling protein
Keywords: kinase, signaling protein, inhibitor complex
Deposited on 2020-05-12, released 2021-03-03
The last revision prior to the SCOPe 2.08 freeze date was dated 2021-03-10, with a file datestamp of 2021-03-05.
Experiment type: XRAY
Resolution: 1.8 Å
R-factor: N/A
AEROSPACI score: 0.45 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Activin receptor type-1
    Species: Homo sapiens [TaxId:9606]
    Gene: ACVR1, ACVRLK2
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q04771 (Start-300)
      • engineered mutation (7)
    Domains in SCOPe 2.08: d7c3ga_
  • Chain 'B':
    Compound: Activin receptor type-1
    Species: Homo sapiens [TaxId:9606]
    Gene: ACVR1, ACVRLK2
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q04771 (Start-300)
      • engineered mutation (7)
    Domains in SCOPe 2.08: d7c3gb_
  • Heterogens: FH0, SO4, EDO, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >7c3gA (A:)
smqrtvahqitllecvgkgrygevwrgswqgenvavkifssrdekswfretelyntvmlr
henilgfiasdmtsrhsstqlwlithyhemgslydylqlttldtvsclrivlsiasglah
lhieifgtqgkpaiahrdlksknilvkkngqcciadlglavmhsqstnqldvgnnprvgt
krymapevldetiqvdcfdsykrvdiwafglvlwevarrmvsngivedykppfydvvpnd
psfedmrkvvcvdqqrpnipnrwfsdptltslaklmkecwyqnpsarltalrikktltki
d

    Sequence, based on observed residues (ATOM records): (download) 
    >7c3gA (A:)
tvahqitllecvgkgrygevwrgswqgenvavkifssrdekswfretelyntvmlrheni
lgfiasdmtsrstqlwlithyhemgslydylqlttldtvsclrivlsiasglahlhieif
gqgkpaiahrdlksknilvkkngqcciadlglavmhsqstnqldvgnnprvgtkrymape
vldetiqvdcfdsykrvdiwafglvlwevarrmvsngivedykppfydvvpndpsfedmr
kvvcvdqqrpnipnrwfsdptltslaklmkecwyqnpsarltalrikktltkid

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >7c3gB (B:)
smqrtvahqitllecvgkgrygevwrgswqgenvavkifssrdekswfretelyntvmlr
henilgfiasdmtsrhsstqlwlithyhemgslydylqlttldtvsclrivlsiasglah
lhieifgtqgkpaiahrdlksknilvkkngqcciadlglavmhsqstnqldvgnnprvgt
krymapevldetiqvdcfdsykrvdiwafglvlwevarrmvsngivedykppfydvvpnd
psfedmrkvvcvdqqrpnipnrwfsdptltslaklmkecwyqnpsarltalrikktltki
d

    Sequence, based on observed residues (ATOM records): (download) 
    >7c3gB (B:)
vahqitllecvgkgrygevwrgswqgenvavkifssrdekswfretelyntvmlrhenil
gfiasdmtsrstqlwlithyhemgslydylqlttldtvsclrivlsiasglahlhieifg
gkpaiahrdlksknilvkkngqcciadlglavmhsqstnqldvgnnprvgtkrymapevl
detiqvdcfdsykrvdiwafglvlwevarrmvsngivedykppfydvvpndpsfedmrkv
vcvdqqrpnipnrwfsdptltslaklmkecwyqnpsarltalrikktltkid