PDB entry 7c2z

View 7c2z on RCSB PDB site
Description: Bromodomain-containing 4 BD1 in complex with 3',4',7,8-Tetrahydroxyflavone
Class: gene regulation
Keywords: BRD4, BD1, 3', 4', 7, 8- tetrahydroxyflavonoid, Acute myeloid leukemia, c-MYC, GENE REGULATION
Deposited on 2020-05-10, released 2021-05-12
The last revision prior to the SCOPe 2.08 freeze date was dated 2021-05-12, with a file datestamp of 2021-05-07.
Experiment type: XRAY
Resolution: 1.3 Å
R-factor: N/A
AEROSPACI score: 0.68 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Bromodomain-containing protein 4
    Species: Homo sapiens [TaxId:9606]
    Gene: BRD4, HUNK1
    Database cross-references and differences (RAF-indexed):
    • Uniprot O60885 (1-End)
      • initiating methionine (0)
    Domains in SCOPe 2.08: d7c2za1, d7c2za2
  • Heterogens: SQH, FMT, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >7c2zA (A:)
mnppppetsnpnkpkrqtnqlqyllrvvlktlwkhqfawpfqqpvdavklnlpdyykiik
tpmdmgtikkrlennyywnaqeciqdfntmftncyiynkpgddivlmaealeklflqkin
elptee

    Sequence, based on observed residues (ATOM records): (download) 
    >7c2zA (A:)
mnppppetsnpnkpkrqtnqlqyllrvvlktlwkhqfawpfqqpvdavklnlpdyykiik
tpmdmgtikkrlennyywnaqeciqdfntmftncyiynkpgddivlmaealeklflqkin
elpte