PDB entry 7c2w

View 7c2w on RCSB PDB site
Description: crystal structure of irak4 kinase in complex with a small molecule inhibitor
Deposited on 2020-05-09, released 2020-11-25
The last revision was dated 2020-12-30, with a file datestamp of 2020-12-25.
Experiment type: XRAY
Resolution: 3.2 Å
R-factor: N/A
AEROSPACI score: 0.18 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: interleukin-1 receptor-associated kinase 4
    Species: Homo sapiens [TaxId:9606]
    Gene: Irak4
    Database cross-references and differences (RAF-indexed):
  • Chain 'B':
    Compound: interleukin-1 receptor-associated kinase 4
    Species: Homo sapiens [TaxId:9606]
    Gene: Irak4
    Database cross-references and differences (RAF-indexed):
  • Chain 'C':
    Compound: interleukin-1 receptor-associated kinase 4
    Species: Homo sapiens [TaxId:9606]
    Gene: Irak4
    Database cross-references and differences (RAF-indexed):
  • Chain 'D':
    Compound: interleukin-1 receptor-associated kinase 4
    Species: Homo sapiens [TaxId:9606]
    Gene: Irak4
    Database cross-references and differences (RAF-indexed):
  • Heterogens: FJ9, HOH

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >7c2wA (A:)
trfhsfsfyelknvtnnfderpisvggnkmgeggfgvvykgyvnnttvavkklaamvdit
teelkqqfdqeikvmakcqhenlvellgfssdgddlclvyvympngslldrlscldgtpp
lswhmrckiaqgaanginflhenhhihrdiksanilldeaftakisdfglarasekfaqt
vmxsrivgttaymapealrgeitpksdiysfgvvlleiitglpavdehrepqllldikee
iedeektiedyidkkmndadstsveamysvasqclhekknkrpdikkvqqllqemt

    Sequence, based on observed residues (ATOM records):
    >7c2wA (A:)
rfhsfsfyelknvtnnfderpisvggnkmgeggfgvvykgyvnnttvavkklaamvditt
eelkqqfdqeikvmakcqhenlvellgfssdgddlclvyvympngslldrlscldgtppl
swhmrckiaqgaanginflhenhhihrdiksanilldeaftakisdfglarasekfaqtv
mxsrivgttaymapealrgeitpksdiysfgvvlleiitglpavdehrepqllldikeei
edeektiedyidkkmndadstsveamysvasqclhekknkrpdikkvqqllqemt

  • Chain 'B':
    Sequence; same for both SEQRES and ATOM records:
    >7c2wB (B:)
trfhsfsfyelknvtnnfderpisvggnkmgeggfgvvykgyvnnttvavkklaamvdit
teelkqqfdqeikvmakcqhenlvellgfssdgddlclvyvympngslldrlscldgtpp
lswhmrckiaqgaanginflhenhhihrdiksanilldeaftakisdfglarasekfaqt
vmxsrivgttaymapealrgeitpksdiysfgvvlleiitglpavdehrepqllldikee
iedeektiedyidkkmndadstsveamysvasqclhekknkrpdikkvqqllqemt

  • Chain 'C':
    Sequence, based on SEQRES records:
    >7c2wC (C:)
trfhsfsfyelknvtnnfderpisvggnkmgeggfgvvykgyvnnttvavkklaamvdit
teelkqqfdqeikvmakcqhenlvellgfssdgddlclvyvympngslldrlscldgtpp
lswhmrckiaqgaanginflhenhhihrdiksanilldeaftakisdfglarasekfaqt
vmxsrivgttaymapealrgeitpksdiysfgvvlleiitglpavdehrepqllldikee
iedeektiedyidkkmndadstsveamysvasqclhekknkrpdikkvqqllqemt

    Sequence, based on observed residues (ATOM records):
    >7c2wC (C:)
rfhsfsfyelknvtnnfderpisvggnkmgeggfgvvykgyvnnttvavkklaamvditt
eelkqqfdqeikvmakcqhenlvellgfssdgddlclvyvympngslldrlscldgtppl
swhmrckiaqgaanginflhenhhihrdiksanilldeaftakisdfglarasekfaqtv
mxsrivgttaymapealrgeitpksdiysfgvvlleiitglpavdehrepqllldikeei
edeektiedyidkkmndadstsveamysvasqclhekknkrpdikkvqqllqemt

  • Chain 'D':
    Sequence, based on SEQRES records:
    >7c2wD (D:)
trfhsfsfyelknvtnnfderpisvggnkmgeggfgvvykgyvnnttvavkklaamvdit
teelkqqfdqeikvmakcqhenlvellgfssdgddlclvyvympngslldrlscldgtpp
lswhmrckiaqgaanginflhenhhihrdiksanilldeaftakisdfglarasekfaqt
vmxsrivgttaymapealrgeitpksdiysfgvvlleiitglpavdehrepqllldikee
iedeektiedyidkkmndadstsveamysvasqclhekknkrpdikkvqqllqemt

    Sequence, based on observed residues (ATOM records):
    >7c2wD (D:)
rfhsfsfyelknvtnnfderpisvggnkmgeggfgvvykgyvnnttvavkklaamvditt
eelkqqfdqeikvmakcqhenlvellgfssdgddlclvyvympngslldrlscldgtppl
swhmrckiaqgaanginflhenhhihrdiksanilldeaftakisdfglarasekfaqtv
mxsrivgttaymapealrgeitpksdiysfgvvlleiitglpavdehrepqllldikeei
edeektiedyidkkmndadstsveamysvasqclhekknkrpdikkvqqllqemt