PDB entry 7c18

View 7c18 on RCSB PDB site
Description: Crystal structure of FumaraseC from Mannheimia succiniciproducens in complex with Fumarate
Class: lyase
Keywords: FumaraseC; Mannheimia succiniciproducens; succinate production; TCA cycle, LYASE
Deposited on 2020-05-02, released 2021-05-05
The last revision prior to the SCOPe 2.08 freeze date was dated 2021-05-05, with a file datestamp of 2021-04-30.
Experiment type: XRAY
Resolution: 2.12 Å
R-factor: N/A
AEROSPACI score: 0.34 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: fumarate hydratase class II
    Species: Mannheimia succiniciproducens (strain MBEL55E) [TaxId:221988]
    Gene: fumC, MS0760
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q65UJ3 (Start-466)
      • engineered mutation (320)
    Domains in SCOPe 2.08: d7c18a_
  • Chain 'B':
    Compound: fumarate hydratase class II
    Species: Mannheimia succiniciproducens (strain MBEL55E) [TaxId:221988]
    Gene: fumC, MS0760
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q65UJ3 (Start-466)
      • engineered mutation (320)
    Domains in SCOPe 2.08: d7c18b_
  • Chain 'C':
    Compound: fumarate hydratase class II
    Species: Mannheimia succiniciproducens (strain MBEL55E) [TaxId:221988]
    Gene: fumC, MS0760
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q65UJ3
      • engineered mutation (320)
    Domains in SCOPe 2.08: d7c18c_
  • Chain 'D':
    Compound: fumarate hydratase class II
    Species: Mannheimia succiniciproducens (strain MBEL55E) [TaxId:221988]
    Gene: fumC, MS0760
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q65UJ3
      • engineered mutation (320)
    Domains in SCOPe 2.08: d7c18d_
  • Heterogens: FUM, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >7c18A (A:)
gamtafriekdtmgevqvpadkywaaqtersrnnfkigpaasmpheiieafgylkkaaaf
antdlgvlpaekrdligqacdeilarklddqfplviwqtgsgtqsnmnlnevianrahvi
nggklgeksiihpnddvnksqssndtyptamhiaaykkvveatipaverlqktlaakaae
fkdvvkigrthlmdatpltlgqefsgyaaqlsfgltaikntlphlrqlalggtavgtgln
tpkgydvkvaeyiakftglpfitaenkfealathdaivethgalkqvamslfkiandirl
lasgprsgigeilipenepgcsimpgkvnptqceamtmvaaqvlgndttisfagsqghfe
lnvfkpvmaanflqsaqliadvcisfdehcatgiqpntpriqhlldsslmlvtalnthig
yenaakiaktahkngttlreeainlglvsaedfdkwvvpadmvgslk

    Sequence, based on observed residues (ATOM records): (download) 
    >7c18A (A:)
afriekdtmgevqvpadkywaaqtersrnnfkigpaasmpheiieafgylkkaaafantd
lgvlpaekrdligqacdeilarklddqfplviwqtgsgtqsnmnlnevianrahvinggk
lgeksiihpnddvnksqssndtyptamhiaaykkvveatipaverlqktlaakaaefkdv
vkigrthlmdatpltlgqefsgyaaqlsfgltaikntlphlrqlalggtavgtglntpkg
ydvkvaeyiakftglpfitaenkfealathdaivethgalkqvamslfkiandirllasg
prsgigeilipenepgcsimpgkvnptqceamtmvaaqvlgndttisfagsqghfelnvf
kpvmaanflqsaqliadvcisfdehcatgiqpntpriqhlldsslmlvtalnthigyena
akiaktahkngttlreeainlglvsaedfdkwvvpadmvgslk

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >7c18B (B:)
gamtafriekdtmgevqvpadkywaaqtersrnnfkigpaasmpheiieafgylkkaaaf
antdlgvlpaekrdligqacdeilarklddqfplviwqtgsgtqsnmnlnevianrahvi
nggklgeksiihpnddvnksqssndtyptamhiaaykkvveatipaverlqktlaakaae
fkdvvkigrthlmdatpltlgqefsgyaaqlsfgltaikntlphlrqlalggtavgtgln
tpkgydvkvaeyiakftglpfitaenkfealathdaivethgalkqvamslfkiandirl
lasgprsgigeilipenepgcsimpgkvnptqceamtmvaaqvlgndttisfagsqghfe
lnvfkpvmaanflqsaqliadvcisfdehcatgiqpntpriqhlldsslmlvtalnthig
yenaakiaktahkngttlreeainlglvsaedfdkwvvpadmvgslk

    Sequence, based on observed residues (ATOM records): (download) 
    >7c18B (B:)
tafriekdtmgevqvpadkywaaqtersrnnfkigpaasmpheiieafgylkkaaafant
dlgvlpaekrdligqacdeilarklddqfplviwqtgsgtqsnmnlnevianrahvingg
klgeksiihpnddvnksqssndtyptamhiaaykkvveatipaverlqktlaakaaefkd
vvkigrthlmdatpltlgqefsgyaaqlsfgltaikntlphlrqlalggtavgtglntpk
gydvkvaeyiakftglpfitaenkfealathdaivethgalkqvamslfkiandirllas
gprsgigeilipenepgcsimpgkvnptqceamtmvaaqvlgndttisfagsqghfelnv
fkpvmaanflqsaqliadvcisfdehcatgiqpntpriqhlldsslmlvtalnthigyen
aakiaktahkngttlreeainlglvsaedfdkwvvpadmvgslk

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >7c18C (C:)
gamtafriekdtmgevqvpadkywaaqtersrnnfkigpaasmpheiieafgylkkaaaf
antdlgvlpaekrdligqacdeilarklddqfplviwqtgsgtqsnmnlnevianrahvi
nggklgeksiihpnddvnksqssndtyptamhiaaykkvveatipaverlqktlaakaae
fkdvvkigrthlmdatpltlgqefsgyaaqlsfgltaikntlphlrqlalggtavgtgln
tpkgydvkvaeyiakftglpfitaenkfealathdaivethgalkqvamslfkiandirl
lasgprsgigeilipenepgcsimpgkvnptqceamtmvaaqvlgndttisfagsqghfe
lnvfkpvmaanflqsaqliadvcisfdehcatgiqpntpriqhlldsslmlvtalnthig
yenaakiaktahkngttlreeainlglvsaedfdkwvvpadmvgslk

    Sequence, based on observed residues (ATOM records): (download) 
    >7c18C (C:)
friekdtmgevqvpadkywaaqtersrnnfkigpaasmpheiieafgylkkaaafantdl
gvlpaekrdligqacdeilarklddqfplviwqtgsgtqsnmnlnevianrahvinggkl
geksiihpnddvnksqssndtyptamhiaaykkvveatipaverlqktlaakaaefkdvv
kigrthlmdatpltlgqefsgyaaqlsfgltaikntlphlrqlalggtavgtglntpkgy
dvkvaeyiakftglpfitaenkfealathdaivethgalkqvamslfkiandirllasgp
rsgigeilipenepgcsimpgkvnptqceamtmvaaqvlgndttisfagsqghfelnvfk
pvmaanflqsaqliadvcisfdehcatgiqpntpriqhlldsslmlvtalnthigyenaa
kiaktahkngttlreeainlglvsaedfdkwvvpadmvgsl

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >7c18D (D:)
gamtafriekdtmgevqvpadkywaaqtersrnnfkigpaasmpheiieafgylkkaaaf
antdlgvlpaekrdligqacdeilarklddqfplviwqtgsgtqsnmnlnevianrahvi
nggklgeksiihpnddvnksqssndtyptamhiaaykkvveatipaverlqktlaakaae
fkdvvkigrthlmdatpltlgqefsgyaaqlsfgltaikntlphlrqlalggtavgtgln
tpkgydvkvaeyiakftglpfitaenkfealathdaivethgalkqvamslfkiandirl
lasgprsgigeilipenepgcsimpgkvnptqceamtmvaaqvlgndttisfagsqghfe
lnvfkpvmaanflqsaqliadvcisfdehcatgiqpntpriqhlldsslmlvtalnthig
yenaakiaktahkngttlreeainlglvsaedfdkwvvpadmvgslk

    Sequence, based on observed residues (ATOM records): (download) 
    >7c18D (D:)
afriekdtmgevqvpadkywaaqtersrnnfkigpaasmpheiieafgylkkaaafantd
lgvlpaekrdligqacdeilarklddqfplviwqtgsgtqsnmnlnevianrahvinggk
lgeksiihpnddvnksqssndtyptamhiaaykkvveatipaverlqktlaakaaefkdv
vkigrthlmdatpltlgqefsgyaaqlsfgltaikntlphlrqlalggtavgtglntpkg
ydvkvaeyiakftglpfitaenkfealathdaivethgalkqvamslfkiandirllasg
prsgigeilipenepgcsimpgkvnptqceamtmvaaqvlgndttisfagsqghfelnvf
kpvmaanflqsaqliadvcisfdehcatgiqpntpriqhlldsslmlvtalnthigyena
akiaktahkngttlreeainlglvsaedfdkwvvpadmvg