PDB entry 7bw8

View 7bw8 on RCSB PDB site
Description: cryo-em structure for the insulin binding region in the ectodomain of the full-length human insulin receptor in complex with 1 insulin
Deposited on 2020-04-14, released 2021-04-14
The last revision was dated 2021-04-14, with a file datestamp of 2021-04-09.
Experiment type: EM
Resolution: 3.8 Å
R-factor: N/A
AEROSPACI score: 0.05 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Insulin receptor
    Species: Homo sapiens [TaxId:9606]
    Gene: INSR
    Database cross-references and differences (RAF-indexed):
  • Chain 'C':
    Compound: Insulin receptor
    Species: Homo sapiens [TaxId:9606]
    Gene: INSR
    Database cross-references and differences (RAF-indexed):
  • Chain 'D':
    Compound: Insulin fusion
    Species: Homo sapiens [TaxId:9606]
    Gene: INS
    Database cross-references and differences (RAF-indexed):

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >7bw8A (A:)
hlypgevcpgmdirnnltrlhelencsvieghlqillmfktrpedfrdlsfpklimitdy
lllfrvygleslkdlfpnltvirgsrlffnyalvifemvhlkelglynlmnitrgsvrie
knnelcylatidwsrildsvednyivlnkddneecgdicpgtakgktncpatvingqfve
rcwthshcqkvcptickshgctaeglcchseclgncsqpddptkcvacrnfyldgrcvet
cpppyyhfqdwrcvnfsfcqdlhhkcknsrrqgchqyvihnnkcipecpsgytmnssnll
ctpclgpcpkvchllegektidsvtsaqelrgctvingsliinirggnnlaaeleanlgl
ieeisgylkirrsyalvslsffrklrlirgetleignysfyaldnqnlrqlwdwskhnlt
itqgklffhynpklclseihkmeevsgtkgrqerndialktngdqascenellkfsyirt
sfdkillrwepywppdfrdllgfmlfykeapyqnvtefdgqdacgsnswtvvdidpplrs
ndpksqnhpgwlmrglkpwtqyaifvktlvtfsderrtygaksdiiyvqtdatnpsvpld
pisvsnsssqiilkwkppsdpngnithylvfwerqaedselfeldyclkglklpsrtwsp
pfesedsqkhnqseyedsageccscpktdsqilkeleessfrktfedylhnvvfvprkts
sgtgaedprpsrkrrslgdvgnvtvavptvaafpntsstsvptspeehrpfekvvnkesl
visglrhftgyrielqacnqdtpeercsvaayvsartmpeakaddivgpvtheifennvv
hlmwqepkepnglivlyevsyrrygdeelhlcvsrkhfalergcrlrglspgnysvrira
tslagngswteptyfyvtdyldvpsniakiiigplifvflfsvvigsiylflrkrqpdgp
lgplyassnpeylsasdvfpcsvyvpdewevsrekitllrelgqgsfgmvyegnardiik
geaetrvavktvnesaslrerieflneasvmkgftchhvvrllgvvskgqptlvvmelma
hgdlksylrslrpeaennpgrppptlqemiqmaaeiadgmaylnakkfvhrdlaarncmv
ahdftvkigdfgmtrdiyetdyyrkggkgllpvrwmapeslkdgvfttssdmwsfgvvlw
eitslaeqpyqglsneqvlkfvmdggyldqpdncpervtdlmrmcwqfnpkmrptfleiv
nllkddlhpsfpevsffhseenkapeseelemefedmenvpldrsshcqreeaggrdggs
slgfkrsyeehipythmnggkkngriltlprsnps

    Sequence, based on observed residues (ATOM records):
    >7bw8A (A:)
gevcpgmdirnnltrlhelencsvieghlqillmfktrpedfrdlsfpklimitdylllf
rvygleslkdlfpnltvirgsrlffnyalvifemvhlkelglynlmnitrgsvrieknne
lcylatidwsrildsvednyivlnkddnercwthshcqkvcptickshgctaeglcchse
clgncsqpddptkcvacrnfyldgrcvetcpppyyhfqdwrcvnfsfcqdlhhkcknsrc
hqyvihnnkcipecpsgytmnssnllctpclgpcpkvchllegektidsvtsaqelrgct
vingsliinirggnnlaaeleanlglieeisgylkirrsyalvslsffrklrlirgetle
ignysfyaldnqnlrqlwdwskhnltitqgklffhynpklclseihkmeevsgtkgrqer
ndialktngdqascenellkfsyirtsfdkillrwepywppdfrdllgfmlfykeapyqn
vtefswtvvdidpplrsndpksqnhpgwlmrglkpwtqyaifvktlvtfsderrtygaks
diiyvqtdatn

  • Chain 'C':
    Sequence, based on SEQRES records:
    >7bw8C (C:)
hlypgevcpgmdirnnltrlhelencsvieghlqillmfktrpedfrdlsfpklimitdy
lllfrvygleslkdlfpnltvirgsrlffnyalvifemvhlkelglynlmnitrgsvrie
knnelcylatidwsrildsvednyivlnkddneecgdicpgtakgktncpatvingqfve
rcwthshcqkvcptickshgctaeglcchseclgncsqpddptkcvacrnfyldgrcvet
cpppyyhfqdwrcvnfsfcqdlhhkcknsrrqgchqyvihnnkcipecpsgytmnssnll
ctpclgpcpkvchllegektidsvtsaqelrgctvingsliinirggnnlaaeleanlgl
ieeisgylkirrsyalvslsffrklrlirgetleignysfyaldnqnlrqlwdwskhnlt
itqgklffhynpklclseihkmeevsgtkgrqerndialktngdqascenellkfsyirt
sfdkillrwepywppdfrdllgfmlfykeapyqnvtefdgqdacgsnswtvvdidpplrs
ndpksqnhpgwlmrglkpwtqyaifvktlvtfsderrtygaksdiiyvqtdatnpsvpld
pisvsnsssqiilkwkppsdpngnithylvfwerqaedselfeldyclkglklpsrtwsp
pfesedsqkhnqseyedsageccscpktdsqilkeleessfrktfedylhnvvfvprkts
sgtgaedprpsrkrrslgdvgnvtvavptvaafpntsstsvptspeehrpfekvvnkesl
visglrhftgyrielqacnqdtpeercsvaayvsartmpeakaddivgpvtheifennvv
hlmwqepkepnglivlyevsyrrygdeelhlcvsrkhfalergcrlrglspgnysvrira
tslagngswteptyfyvtdyldvpsniakiiigplifvflfsvvigsiylflrkrqpdgp
lgplyassnpeylsasdvfpcsvyvpdewevsrekitllrelgqgsfgmvyegnardiik
geaetrvavktvnesaslrerieflneasvmkgftchhvvrllgvvskgqptlvvmelma
hgdlksylrslrpeaennpgrppptlqemiqmaaeiadgmaylnakkfvhrdlaarncmv
ahdftvkigdfgmtrdiyetdyyrkggkgllpvrwmapeslkdgvfttssdmwsfgvvlw
eitslaeqpyqglsneqvlkfvmdggyldqpdncpervtdlmrmcwqfnpkmrptfleiv
nllkddlhpsfpevsffhseenkapeseelemefedmenvpldrsshcqreeaggrdggs
slgfkrsyeehipythmnggkkngriltlprsnps

    Sequence, based on observed residues (ATOM records):
    >7bw8C (C:)
fsyirtsfdkillrwepywppdfrdllgfmlfykeapyqnvtefswtvvdidpplrsndp
ksqnhpgwlmrglkpwtqyaifvktlvtfsderrtygaksdiiyvqtdatnqilkelees
sfrktfedylhnvvfvpr

  • Chain 'D':
    Sequence, based on SEQRES records:
    >7bw8D (D:)
fvnqhlcgshlvealylvcgergffytpktrreaedlqgslqplalegslqkrgiveqcc
tsicslyqlenycn

    Sequence, based on observed residues (ATOM records):
    >7bw8D (D:)
vnqhlcgshlvealylvcgergffytpgiveqcctsicslyqlenycn