PDB entry 7bre

View 7bre on RCSB PDB site
Description: the crystal structure of mll2 in complex with ash2l and rbbp5
Deposited on 2020-03-28, released 2020-07-22
The last revision was dated 2020-10-21, with a file datestamp of 2020-10-16.
Experiment type: XRAY
Resolution: 2.8 Å
R-factor: N/A
AEROSPACI score: 0.2 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Set1/Ash2 histone methyltransferase complex subunit ASH2
    Species: Homo sapiens [TaxId:9606]
    Gene: ASH2L, ASH2L1
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q9UBL3 (1-End)
      • expression tag (0)
      • linker (121-123)
    • Uniprot Q9UBL3 (124-End)
  • Chain 'B':
    Compound: Histone-lysine N-methyltransferase 2B
    Species: Homo sapiens [TaxId:9606]
    Gene: MLL2
    Database cross-references and differences (RAF-indexed):
  • Chain 'C':
    Compound: Retinoblastoma-binding protein 5
    Species: Homo sapiens [TaxId:9606]
    Gene: Rbbp5
    Database cross-references and differences (RAF-indexed):
  • Chain 'D':
    Compound: Set1/Ash2 histone methyltransferase complex subunit ASH2
    Species: Homo sapiens [TaxId:9606]
    Gene: ASH2L, ASH2L1
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q9UBL3 (1-117)
      • linker (120-123)
    • Uniprot Q9UBL3 (124-End)
  • Chain 'E':
    Compound: Histone-lysine N-methyltransferase 2B
    Species: Homo sapiens [TaxId:9606]
    Gene: MLL2
    Database cross-references and differences (RAF-indexed):
  • Chain 'F':
    Compound: Retinoblastoma-binding protein 5
    Species: Homo sapiens [TaxId:9606]
    Gene: Rbbp5
    Database cross-references and differences (RAF-indexed):
  • Heterogens: ZN, SAH

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >7breA (A:)
srvllalhdrapqlkisddrltvvgekgysmvrashgvrkgawyfeitvdemppdtaarl
gwsqplgnlqaplgydkfsyswrskkgtkfhqsigkhyssgygqgdvlgfyinlpedtis
grgsseiifykngvnqgvaykdifegvyfpaislyksctvsinfgpcfkyppkdltyrpm
sdmg

    Sequence, based on observed residues (ATOM records):
    >7breA (A:)
srvllalhdrapqlkisddrltvvgekgysmvrashgvrkgawyfeitvdemppdtaarl
gwsqplgnlqaplgydkfsyswrskkgtkfhqsigkhyssgygqgdvlgfyinlpedrgs
seiifykngvnqgvaykdifegvyfpaislyksctvsinfgpcfkyppkdltyrpmsdm

  • Chain 'B':
    Sequence, based on SEQRES records:
    >7breB (B:)
strratslelpmamrfrhlkktskeavgvyrsaihgrglfckrnidagemvieysgivir
svltdkrekfydgkgigcymfrmddfdvvdatmhgnaarfinhscepncfsrvihvegqk
hivifalrrilrgeeltydykfpiedasnklpcncgakrcrrfln

    Sequence, based on observed residues (ATOM records):
    >7breB (B:)
strratslelpmamrfrhlkktskeavgvyrsaihgrglfckrnidagemvieysgivir
svltdkrekfydgkgigcymfrmddfdvvdatmhgnaarfinhscepncfsrvihvegqk
hivifalrrilrgeeltydykfpiedaklpcncgakrcrrfln

  • Chain 'C':
    Sequence, based on SEQRES records:
    >7breC (C:)
safapdfkeldenveyeeresefdied

    Sequence, based on observed residues (ATOM records):
    >7breC (C:)
fkeldenveyeeresefdie

  • Chain 'D':
    Sequence, based on SEQRES records:
    >7breD (D:)
srvllalhdrapqlkisddrltvvgekgysmvrashgvrkgawyfeitvdemppdtaarl
gwsqplgnlqaplgydkfsyswrskkgtkfhqsigkhyssgygqgdvlgfyinlpedtis
grgsseiifykngvnqgvaykdifegvyfpaislyksctvsinfgpcfkyppkdltyrpm
sdmg

    Sequence, based on observed residues (ATOM records):
    >7breD (D:)
rvllalhdrapqlkisddrltvvgekgysmvrashgvrkgawyfeitvdemppdtaarlg
wsqplgnlqaplgydkfsyswrskkgtkfhqsigkhyssgygqgdvlgfyinlpedtgrg
sseiifykngvnqgvaykdifegvyfpaislyksctvsinfpcfkyppkdltyrpmsdm

  • Chain 'E':
    Sequence, based on SEQRES records:
    >7breE (E:)
strratslelpmamrfrhlkktskeavgvyrsaihgrglfckrnidagemvieysgivir
svltdkrekfydgkgigcymfrmddfdvvdatmhgnaarfinhscepncfsrvihvegqk
hivifalrrilrgeeltydykfpiedasnklpcncgakrcrrfln

    Sequence, based on observed residues (ATOM records):
    >7breE (E:)
strratslelpmamrfrhlkktskeavgvyrsaihgrglfckrnidagemvieysgivir
svltdkrekfydgkgigcymfrmddfdvvdatmhgnaarfinhscepncfsrvihvegqk
hivifalrrilrgeeltydykfpiesnklpcncgakrcrrfln

  • Chain 'F':
    Sequence, based on SEQRES records:
    >7breF (F:)
safapdfkeldenveyeeresefdied

    Sequence, based on observed residues (ATOM records):
    >7breF (F:)
keldenveyeeresefdie