PDB entry 7bjx

View 7bjx on RCSB PDB site
Description: Crystal structure of CHK1-10pt-mutant complex with compound 26
Class: transferase
Keywords: parkinson's disease, leucine-rich repeat kinase 2, lrrk2, checkpoint kinase 1, chk1, mutant, surrogate, kinase inhibitor, sbdd, transferase
Deposited on 2021-01-14, released 2021-07-07
The last revision prior to the SCOPe 2.08 freeze date was dated 2021-07-21, with a file datestamp of 2021-07-16.
Experiment type: XRAY
Resolution: 2.4 Å
R-factor: N/A
AEROSPACI score: 0.28 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Serine/threonine-protein kinase Chk1
    Species: Homo sapiens [TaxId:9606]
    Gene: CHEK1, CHK1
    Database cross-references and differences (RAF-indexed):
    • Uniprot O14757 (0-288)
      • engineered mutation (58)
      • engineered mutation (67)
      • engineered mutation (83)
      • engineered mutation (85-86)
      • engineered mutation (90)
      • engineered mutation (133)
      • engineered mutation (146)
      • engineered mutation (148-149)
      • expression tag (289-296)
    Domains in SCOPe 2.08: d7bjxa_
  • Chain 'B':
    Compound: Serine/threonine-protein kinase Chk1
    Species: Homo sapiens [TaxId:9606]
    Gene: CHEK1, CHK1
    Database cross-references and differences (RAF-indexed):
    • Uniprot O14757 (0-288)
      • engineered mutation (58)
      • engineered mutation (67)
      • engineered mutation (83)
      • engineered mutation (85-86)
      • engineered mutation (90)
      • engineered mutation (133)
      • engineered mutation (146)
      • engineered mutation (148-149)
      • expression tag (289-296)
    Domains in SCOPe 2.08: d7bjxb_
  • Heterogens: U0Q, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >7bjxA (A:)
mavpfvedwdlvqtlgegaygevqlavnrvteeavavkivdmkravdcpenikkeicilk
mlnhenvikfyghrregniqylfmelasggslfdriepdigmpepdaqrffhqlmagvvy
lhgigithrdikphnlllderdnlkiadyslatvfrynnrerllnkmcgtlpyvapellk
rrefhaepvdvwscgivltamlagelpwdqpsdscqeysdwkekktylnpwkkidsapla
llhkilvenpsaritipdikkdrwynkplkkgakrprvtsggvsespsghhhhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >7bjxA (A:)
dwdlvqtlgegaygevqlavnrvteeavavkivdmnikkeicilkmlnhenvikfyghrr
egniqylfmelasggslfdriepdigmpepdaqrffhqlmagvvylhgigithrdikphn
lllderdnlkiadyslatvfrynnrerllnkmcgtlpyvapellkrrefhaepvdvwscg
ivltamlagelpwdqpsdscqeysdwkekktylnpwkkidsaplallhkilvenpsarit
ipdikkdrwynkplk

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >7bjxB (B:)
mavpfvedwdlvqtlgegaygevqlavnrvteeavavkivdmkravdcpenikkeicilk
mlnhenvikfyghrregniqylfmelasggslfdriepdigmpepdaqrffhqlmagvvy
lhgigithrdikphnlllderdnlkiadyslatvfrynnrerllnkmcgtlpyvapellk
rrefhaepvdvwscgivltamlagelpwdqpsdscqeysdwkekktylnpwkkidsapla
llhkilvenpsaritipdikkdrwynkplkkgakrprvtsggvsespsghhhhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >7bjxB (B:)
dwdlvqtlgegevqlavnrvteeavavkivdmnikkeicilkmlnhenvikfyghrregn
iqylfmelasggslfdriepdigmpepdaqrffhqlmagvvylhgigithrdikphnlll
derdnlkiadyslatvfrynnrerllnkmcgtlpyvapellkrrefhaepvdvwscgivl
tamlagelpwdqpsdscqeysdwkekktylnpwkkidsaplallhkilvenpsaritipd
ikkdrwynkplk