PDB entry 7bf6

View 7bf6 on RCSB PDB site
Description: Crystal structure of SARS-CoV-2 macrodomain in complex with remdesivir metabolite GS-441524
Class: viral protein
Keywords: nsp3, macrodomain, SARS-CoV-2, remdesivir, GS-441524, covid-19, Structural Genomics, Structural Genomics Consortium, SGC, VIRAL PROTEIN
Deposited on 2020-12-31, released 2021-01-13
The last revision prior to the SCOPe 2.08 freeze date was dated 2021-07-07, with a file datestamp of 2021-07-02.
Experiment type: XRAY
Resolution: 2.15 Å
R-factor: N/A
AEROSPACI score: 0.36 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: NSP3 macrodomain
    Species: Severe acute respiratory syndrome coronavirus 2 [TaxId:2697049]
    Gene: rep, 1a-1b
    Database cross-references and differences (RAF-indexed):
    • Uniprot P0DTD1 (3-172)
      • expression tag (0-2)
    Domains in SCOPe 2.08: d7bf6a_
  • Chain 'B':
    Compound: NSP3 macrodomain
    Species: Severe acute respiratory syndrome coronavirus 2 [TaxId:2697049]
    Gene: rep, 1a-1b
    Database cross-references and differences (RAF-indexed):
    • Uniprot P0DTD1 (3-172)
      • expression tag (0-2)
    Domains in SCOPe 2.08: d7bf6b1, d7bf6b2
  • Chain 'C':
    Compound: NSP3 macrodomain
    Species: Severe acute respiratory syndrome coronavirus 2 [TaxId:2697049]
    Gene: rep, 1a-1b
    Database cross-references and differences (RAF-indexed):
    • Uniprot P0DTD1 (3-172)
      • expression tag (0-2)
    Domains in SCOPe 2.08: d7bf6c1, d7bf6c2
  • Heterogens: U08, EDO, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >7bf6A (A:)
ghmvnsfsgylkltdnvyiknadiveeakkvkptvvvnaanvylkhgggvagalnkatnn
amqvesddyiatngplkvggscvlsghnlakhclhvvgpnvnkgediqllksayenfnqh
evllapllsagifgadpihslrvcvdtvrtnvylavfdknlydklvssflemk

    Sequence, based on observed residues (ATOM records): (download) 
    >7bf6A (A:)
nsfsgylkltdnvyiknadiveeakkvkptvvvnaanvylkhgggvagalnkatnnamqv
esddyiatngplkvggscvlsghnlakhclhvvgpnvnkgediqllksayenfnqhevll
apllsagifgadpihslrvcvdtvrtnvylavfdknlydklvssflemk

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >7bf6B (B:)
ghmvnsfsgylkltdnvyiknadiveeakkvkptvvvnaanvylkhgggvagalnkatnn
amqvesddyiatngplkvggscvlsghnlakhclhvvgpnvnkgediqllksayenfnqh
evllapllsagifgadpihslrvcvdtvrtnvylavfdknlydklvssflemk

    Sequence, based on observed residues (ATOM records): (download) 
    >7bf6B (B:)
mvnsfsgylkltdnvyiknadiveeakkvkptvvvnaanvylkhgggvagalnkatnnam
qvesddyiatngplkvggscvlsghnlakhclhvvgpnvnkgediqllksayenfnqhev
llapllsagifgadpihslrvcvdtvrtnvylavfdknlydklvssflemk

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >7bf6C (C:)
ghmvnsfsgylkltdnvyiknadiveeakkvkptvvvnaanvylkhgggvagalnkatnn
amqvesddyiatngplkvggscvlsghnlakhclhvvgpnvnkgediqllksayenfnqh
evllapllsagifgadpihslrvcvdtvrtnvylavfdknlydklvssflemk

    Sequence, based on observed residues (ATOM records): (download) 
    >7bf6C (C:)
mvnsfsgylkltdnvyiknadiveeakkvkptvvvnaanvylkhgggvagalnkatnnam
qvesddyiatngplkvggscvlsghnlakhclhvvgpnvnkgediqllksayenfnqhev
llapllsagifgadpihslrvcvdtvrtnvylavfdknlydklvssf