PDB entry 7b43

View 7b43 on RCSB PDB site
Description: Crystal structure of c-MET bound by compound 9
Class: transferase
Keywords: c-met, kinase, folded P-loop, inhibitor, TRANSFERASE
Deposited on 2020-12-02, released 2020-12-09
The last revision prior to the SCOPe 2.08 freeze date was dated 2021-02-03, with a file datestamp of 2021-01-29.
Experiment type: XRAY
Resolution: 1.87 Å
R-factor: N/A
AEROSPACI score: 0.41 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Hepatocyte growth factor receptor
    Species: Homo sapiens [TaxId:9606]
    Gene: MET
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d7b43a_
  • Chain 'B':
    Compound: Hepatocyte growth factor receptor
    Species: Homo sapiens [TaxId:9606]
    Gene: MET
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d7b43b_
  • Heterogens: SW5, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >7b43A (A:)
gntvhidlsalnpelvqavqhvvigpsslivhfnevigrghfgcvyhgtlldndgkkihc
avkslnritdigevsqfltegiimkdfshpnvlsllgiclrsegsplvvlpymkhgdlrn
firnethnptvkdligfglqvakgmkylaskkfvhrdlaarncmldekftvkvadfglar
dmydkeyysvhnktgaklpvkwmaleslqtqkfttksdvwsfgvllwelmtrgappypdv
ntfditvyllqgrrllqpeycpdplyevmlkcwhpkaemrpsfselvsrisaifstfig

    Sequence, based on observed residues (ATOM records): (download) 
    >7b43A (A:)
lsalnpelvqavqhvvigpsslivhfnevigrghfgcvyhgtlldndgkkihcavkslnr
itdigevsqfltegiimkdfshpnvlsllgiclgsplvvlpymkhgdlrnfirnethnpt
vkdligfglqvakgmkylaskkfvhrdlaarncmldekftvkvadfglardmydkeyypv
kwmaleslqtqkfttksdvwsfgvllwelmtrgappypdvntfditvyllqgrrllqpey
cpdplyevmlkcwhpkaemrpsfselvsrisaifstf

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >7b43B (B:)
gntvhidlsalnpelvqavqhvvigpsslivhfnevigrghfgcvyhgtlldndgkkihc
avkslnritdigevsqfltegiimkdfshpnvlsllgiclrsegsplvvlpymkhgdlrn
firnethnptvkdligfglqvakgmkylaskkfvhrdlaarncmldekftvkvadfglar
dmydkeyysvhnktgaklpvkwmaleslqtqkfttksdvwsfgvllwelmtrgappypdv
ntfditvyllqgrrllqpeycpdplyevmlkcwhpkaemrpsfselvsrisaifstfig

    Sequence, based on observed residues (ATOM records): (download) 
    >7b43B (B:)
lsalnpelvqavqhvvigpsslivhfnevigrghfgcvyhgtlldndgkkihcavkslnr
itdigevsqfltegiimkdfshpnvlsllgiclsplvvlpymkhgdlrnfirnethnptv
kdligfglqvakgmkylaskkfvhrdlaarncmldekftvkvadfglardmydkeyypvk
wmaleslqtqkfttksdvwsfgvllwelmtrgappypdvntfditvyllqgrrllqpeyc
pdplyevmlkcwhpkaemrpsfselvsrisaifstfig