PDB entry 7b3f

View 7b3f on RCSB PDB site
Description: Notum S232A in complex with ARUK3003718
Class: hydrolase
Keywords: Notum Inhibitor, HYDROLASE
Deposited on 2020-11-30, released 2021-08-04
The last revision prior to the SCOPe 2.08 freeze date was dated 2021-08-25, with a file datestamp of 2021-08-20.
Experiment type: XRAY
Resolution: 1.39 Å
R-factor: N/A
AEROSPACI score: 0.62 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Palmitoleoyl-protein carboxylesterase NOTUM
    Species: Homo sapiens [TaxId:9606]
    Gene: NOTUM, OK/SW-CL.30
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q6P988 (3-373)
      • cloning artifact (0-2)
      • engineered mutation (154)
      • engineered mutation (252)
      • expression tag (374-382)
    Domains in SCOPe 2.08: d7b3fa_
  • Heterogens: SRK, NAG, SO4, DMS, EDO, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >7b3fA (A:)
etgsaqqlnedlrlhlllntsvtcndgspagyylkesrgsrrwllfleggwycfnrencd
srydtmrrlmssrdwprtrtgtgilssqpeenpywwnanmvfipycssdvwsgassksek
neyafmgaliiqevvrellgrglsgakvlllagsaaggtgvllnvdrvaeqleklgypai
qvrgladsgwfldnkqyrhtdcvdtitcapteairrgirywngvvpercrrqfqegeewn
cffgykvyptlrspvfvvqwlfdeaqltvdnvhltgqpvqeglrlyiqnlgrelrhtlkd
vpasfapaclsheiiirshwtdvqvkgtslpralhcwdrslhdshkasktplkgcpvhlv
dscpwphcnpscptgtkhhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >7b3fA (A:)
edlrlhlllntsvtcndgspagyylkesrgsrrwllfleggwycfnrencdsrydtmrrl
mssrdwprtrtgtgilssqpeenpywwnanmvfipycssdvwsgassksekneyafmgal
iiqevvrellgrglsgakvlllagsaaggtgvllnvdrvaeqleklgypaiqvrgladsg
wfldnkqyrhtdcvdtitcapteairrgirywngvvpercrrqfqegeewncffgykvyp
tlrspvfvvqwlfdeaqltvdnvhlpvqeglrlyiqnlgrelrhtlkdvpasfapaclsh
eiiirshwtdvqvkgtslpralhcwdrslhtplkgcpvhlvdscpwphcnpscpt