PDB entry 7ayh

View 7ayh on RCSB PDB site
Description: Crystal structure of Aurora A in complex with 7-(2-Anilinopyrimidin-4-yl)-1-benzazepin-2-one derivative (compound 2c)
Class: transferase
Keywords: kinase, kinase inhibitor, aurora kinase, stk6, Structural Genomics, Structural Genomics Consortium, SGC, TRANSFERASE
Deposited on 2020-11-12, released 2021-01-13
The last revision prior to the SCOPe 2.08 freeze date was dated 2021-04-14, with a file datestamp of 2021-04-09.
Experiment type: XRAY
Resolution: 2.8 Å
R-factor: N/A
AEROSPACI score: 0.25 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Aurora kinase A
    Species: Homo sapiens [TaxId:9606]
    Gene: AURKA, AIK, AIRK1, ARK1, AURA, AYK1, BTAK, IAK1, STK15, STK6
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d7ayha_
  • Heterogens: S9H

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >7ayhA (A:)
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rreveiqshlrhpnilrlygyfhdatrvylileyaplgtvyrelqklskfdeqrtatyit
elanalsychskrvihrdikpenlllgsagelkiadfgwsvhapssrrttlcgtldylpp
emiegrmhdekvdlwslgvlcyeflvgkppfeantyqetykrisrveftfpdfvtegard
lisrllkhnpsqrpmlrevlehpwitansskpsncqnkesaskqs

    Sequence, based on observed residues (ATOM records): (download) 
    >7ayhA (A:)
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qshlrhpnilrlygyfhdatrvylileyaplgtvyrelqklskfdeqrtatyitelanal
sychskrvihrdikpenlllgsagelkiadftldylppemiegrmhdekvdlwslgvlcy
eflvgkppfeantyqetykrisrveftfpdfvtegardlisrllkhnpsqrpmlrevleh
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