PDB entry 7axu

View 7axu on RCSB PDB site
Description: Structure of WDR5:CS-VIP8 cocrystal after illumination in situ
Class: transferase
Keywords: WDR5, cyclic strained visible-light photoswitches, MLL1 complex disruption, inhibition of hematopoiesis, TRANSFERASE
Deposited on 2020-11-10, released 2021-11-24
The last revision prior to the SCOPe 2.08 freeze date was dated 2021-12-15, with a file datestamp of 2021-12-10.
Experiment type: XRAY
Resolution: 1.68 Å
R-factor: N/A
AEROSPACI score: 0.49 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: WD repeat-containing protein 5
    Species: Homo sapiens [TaxId:9606]
    Gene: WDR5, BIG3
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d7axua_
  • Heterogens: HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >7axuA (A:)
mateekkpeteaaraqptpsssatqskptpvkpnyalkftlaghtkavssvkfspngewl
asssadklikiwgaydgkfektisghklgisdvawssdsnllvsasddktlkiwdvssgk
clktlkghsnyvfccnfnpqsnlivsgsfdesvriwdvktgkclktlpahsdpvsavhfn
rdgslivsssydglcriwdtasgqclktlidddnppvsfvkfspngkyilaatldntlkl
wdyskgkclktytghknekycifanfsvtggkwivsgsednlvyiwnlqtkeivqklqgh
tdvvistachpteniiasaalendktiklwksdc

    Sequence, based on observed residues (ATOM records): (download) 
    >7axuA (A:)
satqskptpvkpnyalkftlaghtkavssvkfspngewlasssadklikiwgaydgkfek
tisghklgisdvawssdsnllvsasddktlkiwdvssgkclktlkghsnyvfccnfnpqs
nlivsgsfdesvriwdvktgkclktlpahsdpvsavhfnrdgslivsssydglcriwdta
sgqclktlidddnppvsfvkfspngkyilaatldntlklwdyskgkclktytghknekyc
ifanfsvtggkwivsgsednlvyiwnlqtkeivqklqghtdvvistachpteniiasaal
endktiklwksdc