PDB entry 7avs

View 7avs on RCSB PDB site
Description: Crystal structure of SOS1 in complex with compound 6
Class: protein binding
Keywords: RasGEF, PROTEIN BINDING
Deposited on 2020-11-06, released 2021-03-24
The last revision prior to the SCOPe 2.07 freeze date was dated 2021-03-24, with a file datestamp of 2021-03-19.
Experiment type: XRAY
Resolution: 2.28 Å
R-factor: N/A
AEROSPACI score: 0.36 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Son of sevenless homolog 1
    Species: Homo sapiens [TaxId:9606]
    Gene: SOS1
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q07889 (1-End)
      • expression tag (0)
    Domains in SCOPe 2.07: d7avsa1, d7avsa2
  • Chain 'B':
    Compound: Son of sevenless homolog 1
    Species: Homo sapiens [TaxId:9606]
    Gene: SOS1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d7avsb_
  • Heterogens: S3Q, IMD, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >7avsA (A:)
geeqmrlpsadvyrfaepdseeniifeenmqpkagipiikagtviklierltyhmyadpn
fvrtflttyrsfckpqellsliierfeipepepteadriaiengdqplsaelkrfrkeyi
qpvqlrvlnvcrhwvehhfydferdayllqrmeefigtvrgkamkkwvesitkiiqrkki
ardngpghnitfqsspptvewhisrpghietfdlltlhpieiarqltllesdlyravqps
elvgsvwtkedkeinspnllkmirhttnltlwfekcivetenleervavvsriieilqvf
qelnnfngvlevvsamnsspvyrldhtfeqipsrqkkileeahelsedhykkylaklrsi
nppcvpffgiyltnilkteegnpevlkrhgkelinfskrrkvaeitgeiqqyqnqpyclr
vesdikrffenlnpmgnsmekeftdylfnksleieprnpkplprfpkkysyplkspgvrp
snprpgt

    Sequence, based on observed residues (ATOM records): (download) 
    >7avsA (A:)
geeqmrlpsadvyrfaepdseeniifegipiikagtviklierltyhmyadpnfvrtflt
tyrsfckpqellsliierfeipepepteadriaiengdqplsaelkrfrkeyiqpvqlrv
lnvcrhwvehhfydferdayllqrmeefigtvrgkamkkwvesitkiiqrkkiardtfqs
spptvewhisrpghietfdlltlhpieiarqltllesdlyravqpselvgsvwtkedkei
nspnllkmirhttnltlwfekcivetenleervavvsriieilqvfqelnnfngvlevvs
amnsspvyrldhtfeqipsrqkkileeahelsedhykkylaklrsinppcvpffgiyltn
ilkteegnpevlkrhgkelinfskrrkvaeitgeiqqyqnqpyclrvesdikrffenlnp
mgnsmekeftdylfnksleieprnpkplprfpkkysyplkspgvrp

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >7avsB (B:)
geeqmrlpsadvyrfaepdseeniifeenmqpkagipiikagtviklierltyhmyadpn
fvrtflttyrsfckpqellsliierfeipepepteadriaiengdqplsaelkrfrkeyi
qpvqlrvlnvcrhwvehhfydferdayllqrmeefigtvrgkamkkwvesitkiiqrkki
ardngpghnitfqsspptvewhisrpghietfdlltlhpieiarqltllesdlyravqps
elvgsvwtkedkeinspnllkmirhttnltlwfekcivetenleervavvsriieilqvf
qelnnfngvlevvsamnsspvyrldhtfeqipsrqkkileeahelsedhykkylaklrsi
nppcvpffgiyltnilkteegnpevlkrhgkelinfskrrkvaeitgeiqqyqnqpyclr
vesdikrffenlnpmgnsmekeftdylfnksleieprnpkplprfpkkysyplkspgvrp
snprpgt

    Sequence, based on observed residues (ATOM records): (download) 
    >7avsB (B:)
eqmrlpsadvyrfaepdseeniifegipiikagtviklierltyhmyadpnfvrtfltty
rsfckpqellsliierfeipepepteadriaiengdqplsaelkrfrkeyiqpvqlrvln
vcrhwvehhfydferdayllqrmeefigtvrgkamkkwvesitkiiqrkkiarfqssppt
vewhisrpghietfdlltlhpieiarqltllesdlyravqpselvgsvwtkedkeinspn
llkmirhttnltlwfekcivetenleervavvsriieilqvfqelnnfngvlevvsamns
spvyrldhtfeqipsrqkkileeahelsedhykkylaklrsinppcvpffgiyltnilkt
eegnpevlkrhgkelinfskrrkvaeitgeiqqyqnqpyclrvesdikrffenlnpmgns
mekeftdylfnksleieprnpkplprfpkkysyplkspgvrp