PDB entry 7avq

View 7avq on RCSB PDB site
Description: crystal structure of haspin in complex with disubstituted imidazo[1,2- b]pyridazine inhibitor (compound 12)
Deposited on 2020-11-05, released 2020-11-18
The last revision was dated 2021-12-08, with a file datestamp of 2021-12-03.
Experiment type: XRAY
Resolution: 1.65 Å
R-factor: N/A
AEROSPACI score: 0.51 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Serine/threonine-protein kinase haspin
    Species: Homo sapiens [TaxId:9606]
    Gene: HASPIN, GSG2
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q8TF76 (23-356)
      • initiating methionine (0)
      • expression tag (1-22)
  • Heterogens: S1Z, NA, GOL, MPD, HOH

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >7avqA (A:)
mhhhhhhssgvdlgtenlyfqsmgecsqkgpvpfshclpteklqrcekigegvfgevfqt
iadhtpvaikiiaiegpdlvngshqktfeeilpeiiiskelsllsgevcnrtegfiglns
vhcvqgsypplllkawdhynstkgsandrpdffkddqlfivlefefggidleqmrtklss
lataksilhqltaslavaeaslrfehrdlhwgnvllkktslkklhytlngksstipscgl
qvsiidytlsrlerdgivvfcdvsmdedlftgdgdyqfdiyrlmkkennnrwgeyhpysn
vlwlhyltdkmlkqmtfktkcntpamkqikrkiqefhrtmlnfssatdllcqhslfk

    Sequence, based on observed residues (ATOM records):
    >7avqA (A:)
gpvpfshclpteklqrcekigegvfgevfqtiadhtpvaikiiaiegpdlvngshqktfe
eilpeiiiskelsllsgevcnrtegfiglnsvhcvqgsypplllkawdhynstkgsandr
pdffkddqlfivlefefggidleqmrtklsslataksilhqltaslavaeaslrfehrdl
hwgnvllkktslkklhytlngksstipscglqvsiidytlsrlerdgivvfcdvsmdedl
ftgdgdyqfdiyrlmkkennnrwgeyhpysnvlwlhyltdkmlkqmtfktkcntpamkqi
krkiqefhrtmlnfssatdllcqhslfk